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Glossary Dystrophic Hairs

hairs damaged or weakened by underlying scalp conditions

Dystrophic hairs are hairs that have been damaged or weakened, often due to underlying conditions such as alopecia areata or other scalp disorders. These hairs typically appear thin, fragile, and may break easily, reflecting a disruption in the normal hair growth cycle. For professionals, the presence of dystrophic hairs can be a diagnostic clue indicating an active disease process affecting the hair follicles.

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Research

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The Early Region of Trichodysplasia Spinulosa Polyomavirus Drives Proliferation, Altered Differentiation, and Ectopic Expression of Hair Follicle Differentiation Markers in Interfollicular Tail Epidermis

research LB1019 The early region of trichodysplasia spinulosa polyomavirus drives proliferation, altered differentiation, and ectopic expression of hair follicle differentiation markers in interfollicular tail epidermis

July 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

In this study, researchers found that TSPyV T antigens can disrupt normal cell differentiation and proliferation in hair follicles and interfollicular epidermis, possibly contributing to trichodysplasia spinulosa pathology.

research Structural changes in hair follicles and sebaceous glands of hairless mice following exposure to sulfur mustard

14 citations , March 2014 in “Experimental and Molecular Pathology”

This study found that sulfur mustard affects hair follicles and sebaceous glands in the skin by causing cellular damage, inflammation, and disrupting wound healing processes in hairless mice.

research The Nude Mutant Gene Foxn1 Is a HOXC13 Regulatory Target during Hair Follicle and Nail Differentiation

68 citations , December 2010 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study suggests a regulatory model where HOXC13 activates Foxn1, affecting hair and nail differentiation, supported by similarities in Hoxc13(tm1Mrc) and Foxn1(nu) mice phenotypes and gene expression patterns.

research Microneedling with Triamcinolone acetonide versus Intralesional Triamcinolone acetonide in treatment of Alopecia Areata

February 2023 in “Al-Azhar International Medical Journal /Al-Azhar International Medical Journal”

In this study, both intralesional and microneedling treatments with triamcinolone acetonide significantly reduced alopecia areata markers, but their clinical responses did not differ significantly, suggesting microneedling as a safe, cost-effective option with minimal complications.

research Microneedling with Triamcinolone acetonide versus Intralesional Triamcinolone acetonide in treatment of Alopecia Areata

February 2023

This study observed that both intralesional triamcinolone acetonide and microneedling with triamcinolone acetonide significantly reduced alopecia areata severity, with no significant difference in effectiveness between the two treatments, suggesting microneedling as an effective and less invasive option.

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Community Join

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community Everything you ever wanted to know about Pelage Pharma's PP405: how it works and what to expect

126 upvotes 2 months ago

PP405 may encourage earlier hair growth and slightly increase visible hair count but does not reverse hair follicle miniaturization in male pattern baldness. It does not address damage to the dermal papilla or broken Wnt signaling.

community Hair Loss Ruins Your Mind: 10x rate of BDD. PF S is not real

in Research/Science 39 upvotes 7 months ago

Hair loss is linked to a higher rate of body dysmorphic disorder (BDD), OCD, and depression. Finasteride and dutasteride are not linked to increased suicidal risk, though some users report mental health side effects.

community What is up with all these body dysmorphic posts lately?

in Chat 49 upvotes 1 year ago

The conversation discusses concerns about body dysmorphia related to hair loss, with some users expressing frustration over posts claiming treatments like finasteride and dutasteride are ineffective or harmful despite minimal hair loss. It emphasizes the importance of early treatment with medications like finasteride and minoxidil for those experiencing hair loss.

community Hairloss is mentally exhausting

24 upvotes 5 years ago

The conversation is about the mental toll of hair loss and seeking alternatives to finasteride. Suggestions include using minoxidil, considering pumpkin seed oil, and possibly seeking counseling for body dysmorphic disorder.

community PP405 Won't Work Long Term: Hair Follicle Damage Due to Abuse of the ISR System

67 upvotes 11 months ago

PP405 may damage hair follicles if used long-term, suggesting cycling might be necessary. Combining it with finasteride could help maintain hair growth.

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Learn

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learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Alopecia Areata

autoimmune disorder causing patchy hair loss

learn PP405

Got small bald patches they say are from stress? PP405 sprays could help bring them back to life. PP405 is an experimental topical gel from Pelage Pharmaceuticals that inhibits the mitochondrial pyruvate carrier; its registered Phase 2 trial (NCT06393452) tested it once daily in 78 adults with pattern hair loss, for safety and tolerability. It is not approved, not for sale, and has not been studied in alopecia areata or stress-related shedding.

learn TDM-105795

What types of alopecia or hair loss conditions might TDM-105795 be designed to target based on current research? TDM-105795 may target non-scarring alopecia, particularly androgenetic alopecia.

learn KY19382

compound that activates Wnt/β-catenin to promote hair regrowth and create new hair follicles

learn GHK-Cu

Heard alopecia areata leaves scar-like spots? Some peptides are helping those areas regrow hair. Alopecia areata patches usually still have living follicles. Peptides are being studied as a possible add-on, but the evidence is small and early. See a dermatologist for treatment.

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Clinics

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Experts

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Unscored
SMP Specialist
Hairo Fallas
Newark, NJ, United States

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Hairo Fallas