September 2016 in “Journal of dermatological science”
This study found that hair-follicle-associated-pluripotent (HAP) stemcells can be cryopreserved for future use in nerve and spinal cord repair, with human trials being planned.
April 2023 in “Journal of Investigative Dermatology”
In this study, using a mouse model, researchers found that inducing senescence in hair follicle stemcells led to hair regeneration failure and sebaceous gland enlargement, akin to androgenetic alopecia features.
6 citations
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July 2022 in “World journal of stem cells”
This study found that human mesenchymal stemcell-derived extracellular vesicles promote the proliferation and migration of hair follicle cells and increase hair shaft elongation in cultured human hair follicles.
10 citations
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January 2016 in “Annals of Dermatology”
This article discusses the factors contributing to acne and reports no new findings, focusing on the role of sebaceous lipids and associated processes.
September 2024 in “Journal of the American Academy of Dermatology”
This study found that estetrol (E4) significantly prolonged the anagen phase and increased hair matrix keratinocyte proliferation in cultured human hair follicles, suggesting its potential as a treatment for female pattern hair loss.
PP405 may damage hair follicles if used long-term, suggesting cycling might be necessary. Combining it with finasteride could help maintain hair growth.
Prolactin may contribute to hair loss, but targeting its receptor won't cure androgenetic alopecia. ABS-201 could be a useful alternative or adjuvant therapy, similar to JAK inhibitors, but not more effective than HMI-115.
PP405 may encourage earlier hair growth and slightly increase visible hair count but does not reverse hair follicle miniaturization in male pattern baldness. It does not address damage to the dermal papilla or broken Wnt signaling.
The user used microneedling, zinc, vitamin D3, biotin, magnesium, saw palmetto, pumpkin seed oil, and a DHT-blocker shampoo with biotin for hair loss. They are considering adding minoxidil due to stagnation in progress.
Laser caps are found to be more effective than 5% minoxidil for treating hair loss, and when combined with minoxidil, they are even more effective. Some users report positive results with laser treatments, while others see no change; the devices are FDA approved, but opinions on their efficacy vary.