24 citations
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September 2005 in “Journal of Cellular Biochemistry”
Retinoids increase steroid sulfatase activity in leukemia cells through RARα/RXR and involves certain pathways like phosphoinositide 3-kinase and ERK-MAP kinase.
High-dose oral minoxidil (>5 mg/day) can increase hair density in some men with androgenetic alopecia, but side effects like extra body hair and heart issues are common. Gradual doseincrease is advised, but adverse effects may lead to discontinuation or dose adjustments.
Hair loss user increased oral minoxidil dose, causing more shedding. Uses 1mg finasteride, Lonitab, and Stemoxydine 5%, expects denser hair in a few months.
The user is experiencing hair thinning after increasing finasteride to 0.5 mg daily and oral minoxidil to 3 mg. They are concerned about whether this is normal and if the recent doseincrease is affecting their hair, as they plan a hair transplant in 5 weeks.
The conversation is about a user experiencing hair shedding after switching from finasteride to dutasteride and increasing their oral minoxidil dose. The user is advised to continue with the current treatment, consider adding topical minoxidil, and consult a dermatologist for potential underlying issues.
A user who has seen results of hair regrowth after 6 months of using finasteride 1.25mg daily, and topical foam minoxidil twice a day for 3 months before switching to once a day; other users have advised against increasing the dose of finasteride due to lack of additional scalp DHT reduction and increased risk of side effects.