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research Laser treatment for female facial hirsutism: are quality-of-life benefits sustainable?

60 citations , December 2015 in “Clinical and experimental dermatology”

This study found that while laser hair removal improves quality of life for women with facial hirsutism, emotional benefits diminish over 30 months and additional treatments may be necessary to maintain improvements.

research The effect of finasteride on the male rat brain

November 2023 in “Research Square (Research Square)”

This animal study found that finasteride, a 5-alpha reductase type 2 inhibitor, decreased dihydrotestosterone levels and c-Fos protein activation in the rat brain, but these effects may diminish after discontinuing the drug.

research Dermal TRPV1 innervations engage a macrophage- and fibroblast-containing pathway to activate hair growth in mice

5 citations , June 2024 in “Developmental Cell”

In this study, activating TRPV1 nociceptors in mice skin stimulated dormant hair follicles and promoted hair growth through a mechanism involving dermal macrophages, fibroblasts, and neuropeptides, highlighting a new role for nociceptors in tissue recovery after injury.

Adverse Side Effects of 5α-Reductase Inhibitors Therapy: Persistent Diminished Libido, Erectile Dysfunction, and Depression in a Subset of Patients

research Adverse Side Effects of 5α‐Reductase Inhibitors Therapy: Persistent Diminished Libido and Erectile Dysfunction and Depression in a Subset of Patients

223 citations , December 2010 in “The Journal of Sexual Medicine”

This review discusses persistent adverse effects of 5α‐reductase inhibitors, like diminished libido and erectile dysfunction, in some patients and highlights the need for patient discussions before therapy, especially for androgenetic alopecia.

research Comparative biology of tissue repair, regeneration and aging

11 citations , June 2016 in “npj Regenerative Medicine”

This symposium discussed why regenerative capacity varies among species and diminishes with age, exploring how these insights could inform regenerative medicine approaches, without presenting new experimental results.

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community Dutasteride 0.5 vs. 2.5? Equally effective if you give it enough time?

in Finasteride/Dutasteride 21 upvotes 3 months ago

Dutasteride at 0.5 mg and 2.5 mg doses may eventually yield similar hair growth results over time, with 0.5 mg being sufficient for many users. Higher doses may not significantly increase benefits and could lead to diminished returns.

community Diminishing returns after 1.25mg of oral Minoxidil

in Minoxidil 26 upvotes 1 month ago

After 1.25mg of oral Minoxidil, additional hair growth is minimal, and side effects increase. Many users suggest starting with 1.25mg and only increasing if necessary, as higher doses show diminishing returns.

community Dutasteride and my semen production

in Finasteride/Dutasteride 74 upvotes 1 year ago

A user experienced sexual side effects, including reduced semen production and numbness, after switching from finasteride to dutasteride for hair loss. They decided to stop dutasteride to prioritize their sexual health and may return to finasteride if issues resolve.

community Magnesium oil worked wonders for me, until it stopped working

4 upvotes 1 year ago

A user experienced significant hair improvement using magnesium oil after stopping finasteride due to side effects, but the effects of magnesium diminished over time. They are seeking alternative treatments for hair loss without using finasteride.

community People absolutely treat you differently when you’re bald/balding compared to when you have hair.

172 upvotes 5 days ago

A 21-year-old experienced aggressive hair loss and noticed a significant change in how people treated him after losing hair, despite being fit and healthy. He initially regained hair using finasteride but stopped due to side effects, leading to a return of hair loss and a perceived decrease in social warmth and friendliness.

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