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GlossaryDrug Reaction with Eosinophilia and Systemic Symptoms (DIHS)

severe allergic reaction to medication causing rash and organ damage

Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) is a severe, potentially life-threatening hypersensitivity reaction to certain medications. It is characterized by a widespread skin rash, fever, swollen lymph nodes, and involvement of internal organs such as the liver, kidneys, and lungs. Eosinophilia, an elevated level of a type of white blood cell called eosinophils, is a hallmark of this condition. Early recognition and discontinuation of the offending drug are crucial for managing DRESS.

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research Prolonged Drug-Induced Hypersensitivity Syndrome/DRESS With Alopecia Areata and Autoimmune Thyroiditis

2 citations, August 2022 in “Federal Practitioner”

A severe medication reaction required long treatment and led to hair loss and thyroid issues.

research HHV-6A and HHV-6B in Drug-Induced Hypersensitivity Syndrome/Drug Reaction with Eosinophilia and Systemic Symptoms

2 citations, January 2014 in “Elsevier eBooks”

The document concludes that reactivation of herpesviruses, especially HHV-6, is linked to severe symptoms and complications in drug-induced hypersensitivity syndrome.

Immune Response Involving the Bulge Region in Addition to Telogen Conversion Contributes to Hair Loss in a Case of Atypical Drug-Induced Hypersensitivity Syndrome

research Immune Response Involving the Bulge Region in Addition to Telogen Conversion Contributes to Hair Loss in a Case of Atypical Drug-Induced Hypersensitivity Syndrome

1 citations, October 2013 in “The Journal of Dermatology”

Hair loss in a drug reaction case involved both a common shedding phase and an immune attack on hair follicle stem cells.

research Phenobarbital

January 2014 in “Reactions Weekly”

A woman experienced unusual hair loss and skin reactions after taking phenobarbital, but her hair grew back after treatment.

research Lesional Skin Histology in Drug-Induced Hypersensitivity Syndrome: A Single Center 10-Year Experience of 37 Patients

April 2023 in “Journal of Investigative Dermatology”

Interface dermatitis is the most common skin change in drug-induced hypersensitivity syndrome.

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