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GlossaryDiabetic Ulcers

open sores on feet due to diabetes-related complications

Diabetic ulcers, also known as diabetic foot ulcers, are open sores or wounds that occur in individuals with diabetes, typically on the feet. These ulcers result from a combination of factors such as poor blood circulation, neuropathy (nerve damage), and a weakened immune system, which impair the body's ability to heal. If left untreated, diabetic ulcers can lead to serious complications, including infections and, in severe cases, amputation.

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research Prostacyclin Pathway to Enhance Wound Healing in Diabetic Foot Ulcers

April 2023 in “Journal of Investigative Dermatology”

Treprostinil, a drug, can delay wound healing in healthy cells but doesn't affect diabetic foot ulcer cells, suggesting further research could help understand its role in treating these ulcers.

research Advanced Polymer Hydrogels That Promote Diabetic Ulcer Healing: Mechanisms, Classifications, and Medical Applications

6 citations , February 2023 in “Biomaterials Research”

Special gels help heal diabetic foot sores and reduce the risk of amputation or death.

research Platelet Rich Plasma Effects on Diabetic Foot Ulcers: A Review

3 citations , March 2023 in “National Journal of Health Sciences”

Platelet Rich Plasma (PRP) therapy may help heal diabetic foot ulcers.

research Human CD133+ Progenitor Cells Promote the Healing of Diabetic Ischemic Ulcers by Paracrine Stimulation of Angiogenesis and Activation of Wnt Signaling

245 citations , April 2009 in “Circulation Research”

The study evaluated the healing potential of human fetal aorta-derived CD133+ progenitor cells and their conditioned medium (CD133+ CCM) in a model of ischemic diabetic ulcers in mice. CD133+ cells, which expressed high levels of Wnt genes, accelerated wound closure and promoted angiogenesis through paracrine effects, including the secretion of VEGF-A and IL-8. These effects were diminished by Wnt antagonists and neutralizing antibodies against VEGF-A or IL-8. The findings suggested that CD133+ cells could stimulate wound healing by activating the Wnt signaling pathway, offering potential new treatments for diabetic ulcers.

research Silicone Elastomer Gel Impregnated with 20(S)-Protopanaxadiol-Loaded Nanostructured Lipid Carriers for Ordered Diabetic Ulcer Recovery

31 citations , September 2019 in “Acta Pharmacologica Sinica”

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