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GlossaryDiabetic Ulcers

open sores on feet due to diabetes-related complications

Diabetic ulcers, also known as diabetic foot ulcers, are open sores or wounds that occur in individuals with diabetes, typically on the feet. These ulcers result from a combination of factors such as poor blood circulation, neuropathy (nerve damage), and a weakened immune system, which impair the body's ability to heal. If left untreated, diabetic ulcers can lead to serious complications, including infections and, in severe cases, amputation.

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research Prostacyclin Pathway to Enhance Wound Healing in Diabetic Foot Ulcers

April 2023 in “Journal of Investigative Dermatology”

Treprostinil, a drug, can delay wound healing in healthy cells but doesn't affect diabetic foot ulcer cells, suggesting further research could help understand its role in treating these ulcers.

research Advanced Polymer Hydrogels That Promote Diabetic Ulcer Healing: Mechanisms, Classifications, and Medical Applications

6 citations, February 2023 in “Biomaterials Research”

Special gels help heal diabetic foot sores and reduce the risk of amputation or death.

research Skin Grafting for the Treatment of Chronic Leg Ulcers: A Systematic Review in Evidence-Based Medicine

56 citations, March 2016 in “International Wound Journal”

Skin grafts are effective for chronic leg ulcers, especially autologous split-thickness grafts for venous ulcers, but more data is needed for diabetic ulcers.

research Major Improvement in Wound Healing Through Pharmacologic Mobilization of Stem Cells in Severely Diabetic Rats

16 citations, January 2020 in “Diabetes”

A new therapy sped up wound healing and reduced scarring in diabetic rats.

research Effect of Decellularized Extracellular Matrix Bioscaffolds Derived from Fibroblasts on Skin Wound Healing and Remodeling

8 citations, June 2022 in “Frontiers in bioengineering and biotechnology”

A patch made from human lung fibroblast material helps heal skin wounds effectively, including diabetic ulcers.

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