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research Expression, Characterization, and Structural Analysis of Human Liver Delta4-3-Ketosteroid 5beta-Reductase (AKR1D1) and Its Disease-Related Mutant P133R

January 2009 in “ScholarlyCommons (University of Pennsylvania)”

The P133R mutation in AKR1D1 enzyme causes harmful bile acid buildup, explaining related health issues.

research Structure of Human Steroid 5α-Reductase 2 with the Anti-Androgen Drug Finasteride

30 citations , October 2020 in “Nature Communications”

Finasteride irreversibly affects human steroid 5α-reductase 2, providing insight into its catalytic mechanism and disease-related mutations.

research Crystal Structure of Steroid Reductase SRD5A Reveals Conserved Steroid Reduction Mechanism

July 2020 in “bioRxiv (Cold Spring Harbor Laboratory)”

The structure of SRD5A reveals how it reduces steroids, aiding drug design for related health conditions.

research Modulating Testosterone Pathway: A New Strategy to Tackle Male Skin Aging?

6 citations , September 2012 in “Clinical Interventions in Aging”

Honokiol might help reduce male skin aging by maintaining testosterone levels.

research Intracrine Androgen Biosynthesis, Metabolism, and Action Revisited

131 citations , September 2017 in “Molecular and Cellular Endocrinology”

The document concludes that blocking the internal pathways that create androgens might help treat cancers that depend on sex hormones.

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community 3.5 months on 5% min. Will I keep improving? (36 M)

in Is this regrowth? 11 upvotes 1 year ago

A 36-year-old has been using 5% Minoxidil for 3.5 months and is considering adding microneedling and PRP. Another user suggests adding finasteride and microneedling for better results.

community 3 and a half months on Fin MWF, min daily and microneedling once a week.

in Progress Pictures 691 upvotes 3 years ago

A user's progress with treating hair loss over 3.5 months, which involves taking finasteride MWF, minoxidil daily and microneedling once a week. There was positive feedback from other users regarding the results.

community M21 I stopped finesterid 3 Months ago... this is how it looks now

in Finasteride/Dutasteride 176 upvotes 1 year ago

A user stopped finasteride due to side effects and rapid hair loss, considering a hair system. Others suggested alternatives like dutasteride, minoxidil, and topical finasteride.

community Hair Regrowth with Novel Hemp Extract - anyone seen this??

in Research/Science 18 upvotes 1 year ago

A user discusses a novel hemp extract for hair regrowth, which showed superior results to finasteride and minoxidil. The formula includes CBD, CBDV, THCV, delta 9 THC, cannabigerol, and cannabinol, combined with menthol, peppermint oil, ethanol, Emu oil, HFA 134A propellant, and dimethicone.

community Shed switching from fin to dut?

in Finasteride/Dutasteride 10 upvotes 1 year ago

A user has been on finasteride for over 1.5 years but is still losing hair, so they're switching to dutasteride and taking both for 3 months before stopping finasteride. They're concerned about potential hair shedding during the switch even when done correctly.

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