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community Prepare to be disappointed by PP405

23 upvotes 7 months ago

Delayed release oral minoxidil is seen as a promising advancement for hair loss treatment, offering safer, higher doses and more consistent hair follicle stimulation compared to current options. However, it is not expected to replace finasteride or dutasteride, as it does not prevent androgenetic alopecia.

community A minoxidil pill just posted strong phase 3 results. Up to 86% of men improved coverage in six months.

345 upvotes 1 month ago

VDPHL01, an extended-release oral minoxidil tablet, showed promising results in improving hair coverage for 79 to 86% of men in a trial, with fewer side effects compared to standard doses. Many users prefer oral minoxidil over topical due to ease of use and fewer side effects, especially for those with pets.

community Are these new hair loss treatments ever gonna release?

43 upvotes 5 months ago

Hair loss treatments like Breezula and PP405 are delayed, with approvals taking years, while existing treatments like minoxidil and finasteride remain popular. New treatments like Clascoterone and Veradermics are in trials, but high costs and lengthy approval processes slow their release.

community The people this data actually matters for aren't talking about efficacy numbers

9 upvotes 4 months ago

Oral minoxidil can cause cardiovascular issues, but an extended release formulation may reduce side effects like heart rate and blood pressure spikes. This new formulation offers a safer option for those who previously had to stop due to health concerns.

community I’m taking Veradermics VDPHL01 - AMA

in Treatment 174 upvotes 4 months ago

A participant using Veradermics VDPHL01, an extended-release oral minoxidil, experienced significant hair regrowth from Norwood 6 to Norwood 3V without side effects. They plan to use dutasteride after the treatment to maintain results.

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Research

5 / 1000+ results

Primary Cicatricial Alopecia: Treatment Approaches and Classification

research Primary cicatricial alopecia

95 citations , November 2016 in “Journal of The American Academy of Dermatology”

This article reviews primary cicatricial alopecias, focusing on lymphocytic forms such as chronic cutaneous lupus erythematosus, according to a classification by the North American Hair Research Society, and reports no new clinical results.

research Multifunctional Hydrogel with Dual Functions of ROS Scavenging and Responsive Antibiotic Release for Synergistic Oral Mucositis Treatment

February 2026 in “ACS Omega”

This study developed a multifunctional hydrogel, QTMP-Gel, which significantly accelerated wound healing in an oral mucositis hamster model by providing antioxidant and antibacterial effects, reducing inflammation, and controlling infection.

research Lipid nanocarriers as innovative strategies for hair regrowth

June 2026 in “Discover Nano”

This review discusses current treatment strategies for alopecia and highlights the potential of lipid-based nanoparticles to improve drug delivery to the scalp and hair follicles, noting their ability to enhance skin penetration and drug stability while outlining associated challenges and the need for further research.

Androgens in Women: Hormone-Modulating Therapies for Androgen-Mediated Cutaneous Disorders

research Androgens in women

34 citations , October 2018 in “Journal of The American Academy of Dermatology”

This review discusses hormone-modulating therapies for androgen-mediated cutaneous disorders in women but reports no new clinical results and highlights the need for more rigorous studies.

research Telogen effluvium: a review

2 citations , January 2019 in “International Journal of Medicine in Developing Countries”

This review discusses telogen effluvium as a common cause of diffuse hair loss and reports no new clinical results, noting diagnostic and treatment challenges.

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Learn

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learn Minoxidil

An essential vasodilator with some anti-androgenic effects

From hypertension to hair: the unexpected story of minoxidil Minoxidil was developed as an oral blood-pressure drug and approved as Loniten in 1979; unwanted hair growth in patients led to topical Rogaine, approved for men in 1988 and for women in 1991. Trials support topical minoxidil for pattern hair loss, while low-dose oral minoxidil is a prescription drug used off-label and needs medical supervision.
Minoxidil: the application and its effects counted in months Expect initial shedding in the first month, with visible results typically by three to six months.
Minoxidil 2%, 5% and 10% which is better to use? In a randomized trial in men, 5% topical minoxidil produced more hair growth than 2%. There is no approved 10% product and no head-to-head trial showing it beats 5%; higher strengths mainly add irritation and systemic absorption. Approved strengths differ by sex, so check the label for your product.
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learn Nanoxidil

learn Castor oil

Castor oil: Can I mix it with minoxidil or finasteride, or will they fight each other? No study has tested castor oil together with minoxidil or finasteride. Oral finasteride works systemically and is not expected to be affected, but a thick oil left on the scalp could change how much minoxidil is absorbed, so the common advice is to keep the two applications hours apart and to ask a doctor or pharmacist first.

learn Tretinoin

the gold standard retinoid in dermatology that's also helpful for hair regrowth alongside Minoxidil

learn Latanoprost

glaucoma medication with hair follicle stimulant effects

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Clinics

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Hair Loss Treatments
Minoxidil Hair Growth LankaMaharagama · LK

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