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research FDA declines approval of testosterone drug for third time

January 2013

This report discusses the FDA's rejection of Aveed, a long-acting testosterone injection, due to safety concerns despite divided advisory committee opinions, without presenting new clinical data.

research Late bedtime was associated with increased androgen and reduced lean mass in women with polycystic ovary syndrome: a cross-sectional study

2 citations , July 2025 in “Journal of Ovarian Research”

This study found that among women with PCOS, a bedtime after midnight was independently linked to higher androgen levels and decreased lean muscle mass.

research New Biomarkers to Evaluate Hyperandrogenemic Women and Hypogonadal Men

14 citations , January 2018 in “Advances in Clinical Chemistry”

This review discusses the evaluation of hyperandrogenemia in women and hypogonadism in men across different life stages and presents biomarkers used for diagnosing male hypogonadism, reporting no new clinical results.

research The Impact of Gender Affirming Hormone Therapy on Physical Performance

July 2023 in “The Journal of Clinical Endocrinology and Metabolism”

This narrative review suggests that, after at least two years of gender-affirming hormone therapy, nonathletic transgender individuals tend to have physical performance levels similar to cisgender individuals, though more controlled research is necessary, particularly among trans athletes.

research Review Article: Practical Aspects of Testosterone Deficiency Syndrome in Clinical Urology

September 2012 in “African Journal of Urology”

This review describes the clinical features of testosterone deficiency syndrome in aging men but reports no new experimental findings, highlighting the need for clinical recognition and treatment of TDS.

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community Fin raised my estrogen but also testosterone?

in Finasteride/Dutasteride 17 upvotes 2 years ago

A user experienced initial side effects from finasteride, including erectile dysfunction and emotional changes, but later noticed increased muscle mass and assertiveness. Hormonal tests showed elevated estrogen and prolactin levels, which slightly decreased over time; the user plans lifestyle changes to see if they help.

community Train your forehead and scalp muscles

in Research/Science 23 upvotes 1 year ago

Training scalp muscles to absorb more DHT is suggested as a hair loss solution, but users debate its effectiveness compared to medications like dutasteride and finasteride. Concerns about side effects of DHT blockers, such as reduced libido, are discussed, with some advocating for natural remedies like scalp massages and healthy living.

community Dutasteride Hormone Roller Coaster - Testosterone down, then up, then level, then estrogen up

4 upvotes 3 years ago

Dutasteride effectively stops hair loss but can cause side effects like sexual dysfunction, muscle mass changes, and testicle shrinkage. Adjusting the dosage may help manage these side effects, but long-term health effects remain a concern.

community My muscles & butt are disappearing on finas, and I’m only taking it because my hair was vanishing too. Help! Details below.

in Finasteride/Dutasteride 7 upvotes 5 years ago

A 39 year old female who has been taking finasteride for 1.5 months and is experiencing side effects such as muscle and butt shrinkage, and weight loss despite still having tight clothing. The user is seeking advice from those with knowledge of bodybuilding and hormones to help figure out the issue.

community Scalp massages: where's the community consensus on this ?

in Treatment 11 upvotes 1 year ago

Scalp massages have mixed reviews for hair loss; some users report reduced shedding and healthier hair, while others see no benefit or worsening conditions. Many prefer proven treatments like minoxidil, finasteride, and dutasteride over massages.

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