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research Alopecia - the search for novel agents continues

11 citations , August 1997 in “Expert Opinion on Therapeutic Patents”

This review discusses nearly 70 patent applications for the treatment of androgenetic alopecia and other hair conditions, highlighting the mechanisms of action explored but reports no clinical results.

research Altered Hormone and Bioactive Lipid Plasma Profile in Rodent Models of Polycystic Ovarian Syndrome Revealed by Targeted Mass Spectrometry

March 2025 in “Journal of Endocrinology and Metabolism”

This study found that while rat models treated with letrozole and dihydrotestosterone exhibit altered sterol, leukotriene, and steroid hormone profiles similar to human PCOS, significant differences remain.

research PSAT217 Estrogen Deficiency as a Cause of Decreased 1- alpha - hydroxylase Activity

November 2022 in “Journal of the Endocrine Society”

In this case study, a woman with high 25(OH)D levels and persistent symptoms showed decreased parathormone after transdermal estrogen therapy, highlighting the importance of assessing both parathormone and estrogen levels in similar patients.

research Steroidogenesis of the testis – new genes and pathways

70 citations , April 2014 in “Annales d'endocrinologie”

This review discusses the pathways of androgen biosynthesis and reports no new findings, highlighting the need to understand the interplay between the classic and backdoor pathways.

research 2-Substituted 4-(Thio)chromenone 6-O-Sulfamates: Potent Inhibitors of Human Steroid Sulfatase

111 citations , August 2002 in “Journal of Medicinal Chemistry”

This study reports that 2-(1-Adamantyl)-4H-thiochromen-4-on-6-O-sulfamate is the most potent steroid sulfatase inhibitor identified so far, exhibiting 170-fold higher activity than the lead compound estrone sulfamate.

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Community Join

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community Thoughts on this hair product mix?

22 upvotes 2 months ago

The user is using a combination of 6% minoxidil, 0.3% finasteride spray in the morning, and 5% RU58841 in the evening for hair loss, considering it an aggressive approach. They are concerned about absorption issues and prefer topical treatments to avoid systemic side effects, especially while using anabolic steroids.

community Ever notice how it's always the same 3-4 actors that people refer to when telling you to shave it?

145 upvotes 1 month ago

People often reference a few bald actors like Dwayne Johnson and Jason Statham as examples of looking good without hair, but many believe having hair is generally more attractive. Some use treatments like finasteride and hair transplants to maintain hair, while others feel insecure about baldness and the challenges of shaving their heads.

community 6 months on DUT, should I be disappointed?

4 upvotes 5 months ago

The user has been using finasteride and dutasteride for six months, experiencing a complete stop in hair shedding but minimal regrowth. They are considering adding RU58841 for potential regrowth, with advice suggesting patience as significant results often take 12-24 months.

community 4 months finasteride / oral min

50 upvotes 3 weeks ago

A 36-year-old started using 0.5mg finasteride and 2.5mg oral minoxidil daily for hair loss, reporting positive results without side effects. Despite criticism about photo lighting, the user remains optimistic about continued improvement.

community Minoxidil alone, 4 months consistent usage

in Is this regrowth? 525 upvotes 1 year ago

Minoxidil 5% foam was used twice daily for 4 months, resulting in visible hair regrowth. Users discussed adding finasteride for better long-term results, with concerns about its side effects and alternatives like breezula and clascoterone.

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Learn

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learn Hair Transplant

What results can I expect from a hair transplant? Clinics say new hair usually starts growing around 3 to 4 months after surgery, with full results after about a year or longer. Results vary.
Do hair transplants look natural? Clinics say a well-done transplant can look natural, but results vary with the surgeon, your hair and donor supply, and scars can show with very short hair.
Is a hair transplant permanent? Transplanted hair usually lasts long term, but it is not guaranteed and the hair around it can keep thinning, so the overall result can change with time.
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learn Scalp Micropigmentation

How long does Scalp Micropigmentation last, and does it need touch-ups over time? Providers say SMP usually needs a touch-up every 1 to 5 years. It fades but does not fully disappear, and removal needs laser treatment that may be incomplete.

learn Thymosin Beta 4

learn Stem Cell Factor

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Experts

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