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GlossaryKeratin 16

protein providing structural support in skin, hair, and nails

Keratin 16 (K16) is a type of protein found in the skin, hair, and nails that helps provide structural support and resilience. It is particularly important in the body's response to stress or injury, as it is upregulated in conditions like psoriasis and certain types of alopecia, where the skin or hair follicles are damaged.

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research Overexpression of Human Keratin 16 Produces a Distinct Skin Phenotype in Transgenic Mouse Skin

25 citations , September 1995 in “Biochemistry and Cell Biology”

High levels of human keratin 16 in mice cause skin lesions and abnormal skin development.

The Pathogenesis of Alopecia Areata

research The Pathogenesis of Alopecia Areata

January 2015

Alopecia areata is an autoimmune disease affecting hair follicles and may harm heart health.

The Human Skin as a Hormone Target and an Endocrine Gland

research The Human Skin as a Hormone Target and an Endocrine Gland

146 citations , January 2004 in “Hormones”

Human skin acts like a hormone-producing organ, making and managing various hormones important for skin and hair health.

Harnessing Neuroendocrine Controls of Keratin Expression: A New Therapeutic Strategy for Skin Diseases?

research Harnessing Neuroendocrine Controls of Keratin Expression: A New Therapeutic Strategy for Skin Diseases?

26 citations , May 2014 in “BioEssays”

Using neurohormones to control keratin can lead to new skin disease treatments.

Neuroendocrine Controls of Keratin Expression in Human Skin

research Neuroendocrine Controls of Keratin Expression in Human Skin

December 2018 in “IntechOpen eBooks”

Neurohormones help control skin health and could treat skin disorders.

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