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learn Cyproterone

a synthetic anti-androgen and weak progestogen that inhibits DHT binding to androgen receptor

Is cyproterone only for women, or can men use it too? Cyproterone acetate is not a women-only drug — published reports describe use in men for prostate cancer, paraphilic disorders and gender-affirming therapy — but it is not FDA-approved for any indication, and European regulators restricted higher doses over a dose-related meningioma risk.
Do I need a prescription to take cyproterone? Cyproterone acetate is a prescription-only medicine in every country that licenses it, and it has no FDA approval in the United States — regulators require a prescriber because the drug needs hormonal and liver monitoring and carries a dose-related meningioma risk flagged by the EMA in 2020.
Is cyproterone safe to use during gender transition? Regulators and a large French cohort study link higher-dose, long-term cyproterone acetate to meningioma, and its label also lists liver-enzyme and mood effects — so it is not a drug anyone should call safe in the abstract, and its use in gender-affirming care is a prescriber's decision with monitoring.

learn hydrocortisone acetate IP

learn Pyrilutamide

highly targeted anti-androgen that might have minimal systemic effects

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Research

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Use of Cyproterone Acetate in the Treatment of Acne, Hirsutism, and Virilism

research Use of cyproterone acetate (CPA) in the treatment of acne, hirsutism and virilism

232 citations , June 1975 in “Journal of Steroid Biochemistry”

In this study, a treatment regimen combining cyproterone acetate and ethinyl estradiol significantly improved acne and seborrhoea in most women after three months, but had varied effects on hirsutism and alopecia.

research Cyproterone Acetate in the Treatment of Sexual Disorders: Pharmacological Base and Clinical Experience

30 citations , July 2009 in “Experimental and clinical endocrinology & diabetes”

This article reviews the use of cyproterone acetate for conditions like prostate cancer and sexual disorders, highlighting its effects on libido but reporting no new specific trial results.

research Cyproterone acetate for severe hirsutism:results of a double‐blind dose‐ranging study*

94 citations , July 1991 in “Clinical endocrinology”

In this study, cyproterone acetate at 2 mg daily was found to be as effective as higher doses in reducing hair growth for hirsute women over 12 months.

Risk of Meningioma Among Users of High Doses of Cyproterone Acetate Compared With the General Population: Evidence From a Population-Based Cohort Study

research Risk of meningioma among users of high doses of cyproterone acetate as compared with the general population: evidence from a population-based cohort study

88 citations , May 2011 in “British Journal of Clinical Pharmacology”

This study found that high doses of cyproterone acetate were associated with an increased risk of meningioma, especially with exposure longer than one year.

The Importance of Adequate Serum Ferritin Levels During Oral Cyproterone Acetate and Ethinyl Estradiol Treatment of Diffuse Androgen-Dependent Alopecia in Women

research The importance of adequate serum ferritin levels during oral cyproterone acetate and ethinyl oestradiol treatment of diffuse androgen-dependent alopecia in women

83 citations , April 1992 in “Clinical Endocrinology”

This study found that treatment with cyproterone acetate and ethinyl oestradiol increased hair density in women with diffuse androgen-dependent alopecia, particularly when serum ferritin levels were above 40 μg/l.

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Community Join

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community The lowest cyproterone dose to stop mpb

4 upvotes 3 years ago

The conversation discusses using cyproterone acetate at 12.5 mg to manage hair loss, with concerns about its effects on testosterone and potential health issues. Other treatments mentioned include finasteride, dutasteride, minoxidil, and RU58841, with varying experiences and outcomes.

community Are there any men here who have taken bicalutamide without estradiol?

4 upvotes 4 years ago

Men discussing hair loss treatments, including bicalutamide, cyproterone acetate, dutasteride, minoxidil, and RU58841. They share experiences and concerns about side effects like infertility, liver health, and feminization.

community Using the nuclear stack and still losing hair... Is this the end for my hair?

4 upvotes 3 years ago

The user is experiencing ongoing hair loss despite using a comprehensive treatment regimen including dutasteride, oral minoxidil, cyproterone acetate, transdermal estradiol, and topical bicalutamide. They suspect cyproterone acetate may be worsening their hair loss and are considering switching to injection monotherapy.

community Guy switched back to fin after Dut destroyed his hair (photo proof)

76 upvotes 10 months ago

A person experienced hair loss after switching from finasteride to dutasteride and returned to finasteride, adding oral minoxidil. Dutasteride may increase scalp testosterone, worsening hair loss for some individuals.

community How cyproterone acetate and spironolactone come to my mind whenever I look in the mirror

in Satire 11 upvotes 9 months ago

The conversation humorously discusses hair loss treatments, mentioning spironolactone and cyproterone acetate. It reflects a sense of frustration and satire about the effectiveness of these treatments.

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Clinics

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Experts

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