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Intratumoral De Novo Steroid Synthesis Activates Androgen Receptor in Castration-Resistant Prostate Cancer and Is Upregulated by Treatment with CYP17A1 Inhibitors

research Intratumoral De Novo Steroid Synthesis Activates Androgen Receptor in Castration-Resistant Prostate Cancer and Is Upregulated by Treatment with CYP17A1 Inhibitors

402 citations, August 2011 in “Cancer research”

Prostate cancer cells can make their own androgens to activate the androgen receptor, and treatments like abiraterone may increase this ability, suggesting new therapies should target the entire steroid-making pathway.

research Repurposing Steroidogenesis Inhibitors for the Therapy of Neuropsychiatric Disorders: Promises and Caveats

10 citations, May 2018 in “Neuropharmacology”

Drugs for hormone-related conditions might help treat mental disorders but could have serious side effects.

Early Embryonic Exposure of Freshwater Gastropods to Pharmaceutical 5-Alpha-Reductase Inhibitors Results in a Surprising Open-Coiled 'Banana-Shaped' Shell

research Early Embryonic Exposure of Freshwater Gastropods to Pharmaceutical 5-Alpha-Reductase Inhibitors Results in a Surprising Open-Coiled 'Banana-Shaped' Shell

13 citations, November 2019 in “Scientific reports”

Certain drugs change freshwater snail shells to a "banana" shape.

research Identification of Potential Cytochrome P450c 17 Alpha Inhibitors for the Treatment of PCOS via Scaffold Hopping and Fragment-Based De-Novo Drug Design

February 2024

research Androgen Receptor Modulators: A Review of Recent Patents and Reports (2012-2018)

23 citations, May 2019 in “Expert Opinion on Therapeutic Patents”

New androgen receptor modulators show promise for treating diseases like prostate cancer and muscle wasting.

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Community Join

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community Is Keto shampoo 2% even worth starting?

in Ketoconazole 45 upvotes 1 month ago

Ketoconazole shampoo is primarily for scalp health and reducing inflammation, not hair regrowth. Combining ketoconazole with finasteride can yield similar results to using minoxidil and finasteride together.

community My hairloss stack, progress pics soon maybe for 1 year RU

in Technology 49 upvotes 1 year ago

The conversation is about a user's hair loss treatment routine, which includes RU58841 for 9 months and Dutasteride for 6 months, with other unspecified treatments considered extra. One user inquired about the source of RU58841.

community One year anti androgen update CROWN

in Finasteride/Dutasteride 338 upvotes 1 year ago

User used Finasteride, Dutasteride, and Minoxidil for one year to treat hair loss. They discussed possibly trying RU58841 or pyrilutamide in the future.

community We need to keep these snake oil companies accountable.

in Treatment 124 upvotes 3 months ago

Biotin is being misleadingly marketed as a primary treatment for androgenic alopecia, overshadowing more effective treatments like finasteride and minoxidil. There is a call for increased awareness and accountability to prevent misinformation.

community I'm a tressless woman who's ready to call it quits.

in Female 14 upvotes 5 years ago

A woman who is considering giving up on her hair loss journey after trying minoxidil and spironolactone, but other posters offer words of encouragement and suggest the use of wigs.

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