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research Non-viral delivery of the CRISPR/Cas system: DNAversusRNAversusRNP

21 citations , January 2022 in “Biomaterials Science”

This article reviews CRISPR/Cas system delivery methods for genome editing and highlights RNA's promise in non-viral in vivo applications but reports no new clinical results.

research Strategies for High-Efficiency Mutation Using the CRISPR/Cas System

29 citations , February 2022 in “Frontiers in Cell and Developmental Biology”

This review discusses strategies to improve CRISPR/Cas systems by addressing limitations like off-target effects and delivery inefficiencies, offering practical guidance and highlighting future applications, but reports no new research findings.

research Advances in nanomaterial-mediated CRISPR/Cas delivery: from lipid nanoparticles to vesicle-derived systems

1 citations , January 2026 in “Frontiers in Bioengineering and Biotechnology”

This review discusses various nanocarriers for gene and genome editing therapies, highlighting that ionizable lipid nanoparticles show advanced delivery performance, while emerging polymer-based and exosome-inspired carriers are rapidly advancing for targeted applications.

research Current and prospective strategies for advancing the targeted delivery of CRISPR/Cas system via extracellular vesicles

21 citations , June 2023 in “Journal of Nanobiotechnology”

This review explores current strategies to enhance extracellular vesicle-based delivery of CRISPR/Cas systems, addressing efficiency challenges and suggesting future directions to bridge gene editing technologies with clinical applications.

research Delivery of Tissue-Targeted Scalpels: Opportunities and Challenges for In Vivo CRISPR/Cas-Based Genome Editing

60 citations , July 2020 in “ACS Nano”

This review discusses the progress and challenges in delivering CRISPR/Cas9 systems for in vivo genome editing, highlighting current methods and opportunities for future therapeutic applications.

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community The pessimism about the Crisp Cas 9 is excessive

12 upvotes 11 months ago

CRISPR Cas9 could potentially treat baldness by targeting specific genes in hair follicles without affecting other body functions. There is optimism about its future use, despite ethical concerns and the current reliance on treatments like minoxidil and finasteride.

community Potential ( but not yet confirmed ) pp405 leak through korean media.

233 upvotes 11 months ago

A peptide-based hair loss treatment, PP405, reportedly increased hair density by 62% in 90 days, but these claims are unverified and met with skepticism. Users compared PP405 to Minoxidil and Finasteride, expressing doubts about its effectiveness without more evidence.

community Pp405 - it has to work. It has to.

171 upvotes 6 months ago

Hair loss treatments, including PP405, minoxidil, finasteride, and RU58841, with hopes for future solutions. Participants discuss the emotional impact of hair loss and consider alternatives like hair transplants or acceptance.

community Thoughts on the future of pp405?

43 upvotes 10 months ago

PP405 is considered a promising hair loss treatment, potentially replacing minoxidil but not finasteride. Users are hopeful for future treatments like GT20029 and VDPHL01, while remaining cautious about effectiveness and side effects.

community DHT is making fun of you, let's not suffer!

17 upvotes 11 months ago

DHT negatively affects scalp hair while promoting body hair growth, causing frustration due to the lack of permanent solutions for baldness. Users discuss treatments like finasteride and potential future solutions like CRISPR technology.

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