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GlossaryTofacitinib (CP-690550)

inhibits Janus kinase enzymes to treat autoimmune conditions

Tofacitinib, also known by the brand name Xeljanz, is a medication that inhibits Janus kinase (JAK) enzymes, which play a role in the inflammatory process. It is used to treat autoimmune conditions such as rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis, and has also shown promise in treating alopecia areata, a condition that causes hair loss.

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PSS20 Mediation Modeling and Measurement Characteristics of the Itch Severity Score from a Phase 2B Trial of Oral CP-690-550 in Patients with Moderate-to-Severe Plaque Psoriasis

research PSS20 Mediation Modeling and Measurement Characteristics of the Itch Severity Score from a Phase 2B Trial of Oral CP-690-550 in Patients with Moderate-to-Severe Plaque Psoriasis

May 2011 in “Value in Health”

CP-690,550 significantly reduced itching in patients with moderate-to-severe plaque psoriasis.

research The Changing Landscape of Alopecia Areata: The Therapeutic Paradigm

77 citations, June 2017 in “Advances in Therapy”

New treatments for Alopecia Areata, like JAK inhibitors, show promise for hair regrowth and are likely to change future treatment approaches.

research PSS21 Gap Analysis for Patient-Reported Outcomes Measures for Alopecia

May 2011 in “Value in Health”

No current patient-reported outcome measure fully meets FDA requirements for alopecia treatments.

research Killing Two Birds with One Stone: Oral Tofacitinib Reverses Alopecia Universalis in a Patient with Plaque Psoriasis

185 citations, June 2014 in “Journal of Investigative Dermatology”

A man with severe hair loss and skin disease regrew his hair with no side effects after taking tofacitinib.

research Tofacitinib for the Treatment of Severe Alopecia Areata and Variants: A Study of 90 Patients

238 citations, November 2016 in “Journal of The American Academy of Dermatology”

Tofacitinib is effective and safe for severe hair loss, but full regrowth is less likely after 10 years of hair loss.

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community for last post accusing me of hair transplant

in Progress Pictures 2 years ago

A user's transformation due to their efforts in fighting hair loss, which was achieved without a hair transplant; the discussion includes advice about treatments such as minoxidil and finasteride.

community About to add topical melatonin to my 5% minoxidil solution. What's would be the right concentration?

in Research/Science 15 upvotes 3 years ago

The user added melatonin to their 5% minoxidil solution for hair growth, using a concentration of 0.0033%, which equates to roughly 2mg for a 60ml bottle. They later reported no significant difference and planned to continue the treatment for a few more months before potentially stopping to observe any changes in shedding.

community Wanted to give another update with another month down using finasteride, minoxidil, and micro needling. Trying to give consistent progress updates.

in Progress Pictures 515 upvotes 3 years ago

User shares progress update on hair loss treatment using finasteride, minoxidil, and microneedling. Others congratulate and ask questions about treatment details, such as microneedling tool, needle size, and side effects.

community What brand of Redensyl do you use?

in Question 6 upvotes 4 years ago

User is experiencing issues with Minoxidil and is considering switching to Redensyl, specifically asking for brand recommendations. The Ordinary - Multi Peptide is mentioned, but the user seeks other brand experiences.

community Vitamin E

20 upvotes 6 years ago

Vitamin E was discussed as a treatment for hair shedding, with a specific form mentioned. A user shared a link to a study and started taking the Vitamin E variants used.

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