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research DKK1 Mediated Inhibition of Wnt Signaling in Postnatal Mice Leads to Loss of TEC Progenitors and Thymic Degeneration

56 citations , February 2010 in “PLOS ONE”

Blocking Wnt signaling in young mice causes thymus shrinkage and cell loss, but recovery is possible when the block is removed.

Morphogenesis and Maintenance of the 3D Thymic Medulla and Prevention of Nude Skin Phenotype Require FoxN1 in Pre- and Post-Natal K14 Epithelium

research Morphogenesis and Maintenance of the 3D Thymic Medulla and Prevention of Nude Skin Phenotype Require FoxN1 in Pre- and Post-Natal K14 Epithelium

21 citations , November 2010 in “Journal of molecular medicine”

FoxN1 gene is essential for proper thymus structure and preventing hair loss.

Heterozygous FOXN1 Variants Cause Low TRECs and Severe T Cell Lymphopenia, Revealing a Crucial Role of FOXN1 in Supporting Early Thymopoiesis

research Heterozygous FOXN1 Variants Cause Low TRECs and Severe T Cell Lymphopenia, Revealing a Crucial Role of FOXN1 in Supporting Early Thymopoiesis

53 citations , August 2019 in “American journal of human genetics”

FOXN1 gene variants cause low T cells and immune issues from birth.

research Biological Significance of FoxN1 Gain-of-Function Mutations During T and B Lymphopoiesis in Juvenile Mice

16 citations , October 2014 in “Cell death and disease”

FoxN1 overexpression in young mice harms immune cell and skin development.

research Developing Stratified Epithelia: Lessons from the Epidermis and Thymus

27 citations , August 2014 in “Wiley interdisciplinary reviews. Developmental biology”

The skin and thymus develop similarly to protect and support immunity.

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community EU Shouldn't Ban Fin & Dut: PFS is NOT REAL.

in Research/Science 11 upvotes 9 months ago

Finasteride and Dutasteride do not cause depression or "Post Finasteride Syndrome," with concerns often linked to the nocebo effect and preexisting mental health issues. The EU is unlikely to ban these drugs, but access may become more restricted due to ongoing debates.

community Does someone like Prince William have such intense balding genetics that not even Dutasteride can save them?

in Chat 113 upvotes 8 months ago

Some men have strong balding genetics that treatments like Dutasteride, Minoxidil, or Finasteride may not fully address. Early intervention is believed to help, but many accept hair loss without treatment.

community 4 years of progress pics (Fin only). Hair feels way less dense and is constantly itchy. 30M.

in Progress Pictures 15 upvotes 2 years ago

User has been on Fin for 6 years and shares 4 years of progress pictures, noticing less dense and itchy hair. Replies suggest visiting a dermatologist, considering Dutasteride and Minoxidil, checking bloodwork, and evaluating lifestyle factors.

community I’ve been on dutesteride and oral minoxidil for two years now and I’ve only lost ground…

in Treatment 42 upvotes 1 year ago

A user on dutasteride and oral minoxidil for two years reports worsening hair loss and is seeking advice. Suggestions include consulting a professional for underlying causes, acknowledging that treatments don't work for everyone, and considering dosage adjustments or additional treatments.