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GlossaryTransient Receptor Potential Channels

ion channels involved in sensory perception and physiological processes

Transient Receptor Potential (TRP) channels are a group of ion channels located in the cell membrane that play a crucial role in various physiological processes, including sensation and temperature regulation. These channels respond to a wide range of stimuli, such as temperature changes, pH levels, and mechanical stress, and are involved in sensory functions like pain perception and taste.

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community Physician here AMA – 30M oral Fin 1-1.25 mg daily

in Update 47 upvotes 2 years ago

Hair loss treatments, specifically the use of finasteride, microneedling and potentially oral minoxidil. People discussed their experiences with finasteride, its effects on sexual behaviors, as well as potential solutions such as tadalafil or using other growth factor signal peptides for hope in curing male pattern baldness.

community Testosterone is 1600, would taking low dose anti-androgens be a viable treatment option for people who’s T spikes on DHT-blockers?

in Treatment 46 upvotes 1 year ago

The post and conversation are about the user's high testosterone levels and their worsening hair loss despite trying various treatments. They are considering using low doses of anti-androgens to lower their testosterone levels as a potential solution.

community Creatine's effect on Hair Loss and DHT

in Research/Science 100 upvotes 8 months ago

A 21-year-old male managed to control his hair loss using Nizoral, RU58841, and finasteride, but experienced increased scalp itchiness after starting creatine, which subsided upon stopping creatine. Users shared mixed experiences on whether creatine affects hair loss, with some reporting negative effects and others seeing no change or defending its benefits.

community PYRILUTAMIDE PHASE 3 RESULTS : No statistical significance

in Research/Science 123 upvotes 11 months ago

The phase 3 trial results for Pyrilutamide showed no significant difference from the control treatment in increasing hair count, leading to the company halting its development. Users discussed their disappointment and skepticism about hair loss treatments, with some mentioning other treatments like Minoxidil, Finasteride, and RU58841.

community Pyrilutamide just launched internationally, and all you're doing is hating

in Product 3 months ago

The post and conversation are about the high cost and skepticism surrounding pyrilutamide as a hair loss treatment, with comparisons to minoxidil, finasteride, and RU58841. The original poster defends pyrilutamide's effectiveness and criticizes others for dismissing it without proper understanding.

community GT20029 China Phase II Trial For AGA Reached Primary Endpoint

in Research/Science 136 upvotes 7 months ago

The GT20029 tincture, a topical androgen receptor degrader, showed significant hair growth and good safety in a China Phase II trial for male androgenetic alopecia (AGA), with the 1% dose twice weekly identified as optimal. The company plans to initiate Phase III trials in China and Phase II in the U.S., and the treatment also shows promise for acne.

community ~5 months topical minoxidil + oral finasteride results (swipe images). Slacked with minoxidil this past month, trying to wean off anyways. My last update because I’m hopping off fin and switching to RU in a few weeks (nothing to do with fin efficacy, just experimenting).

in Progress Pictures 145 upvotes 4 years ago

The user experienced significant hair thickening after using topical minoxidil and oral finasteride for about 5 months and is considering switching from finasteride to RU58841. Other users encourage the original poster to continue the current treatment due to the positive results.

community 23 years on Fin/Dut… my story so far…

in Treatment 19 upvotes 2 years ago

A user's 23 year experience with Finasteride/Dutasteride and their current consideration of adding Minoxidil to their treatments for hair loss.

community Anyone else realize how many younger guys are balding?

in Chat 262 upvotes 1 month ago

Many younger men are experiencing hair loss due to genetics, diet, stress, and lifestyle changes. Treatments like finasteride and minoxidil are mentioned, with some users noting improvements.

community pyrilutamide GB update please? Anything no matter how big or small

in Update 30 upvotes 2 years ago

The effects of Finasteride on hair loss and its side-effects, such as aching balls. The user has been taking it for two years with no changes to the symptom.

community Transient and Permanent Effects of Finasteride Use

in Research/Science 154 upvotes 3 years ago

Potential side effects of 5AR inhibitors like finasteride and dutasteride. Users debate risks, benefits, and personal experiences with these hair loss treatments.

community Roughly 4 months on the fin/min/microneedling combo.

in Progress Pictures 182 upvotes 1 year ago

A hair loss regime consisting of finasteride, minoxidil and microneedling that was started 4 months ago with minimal side effects reported. The user also uses Nizoral once a week.

community Fluridi + minoxidil (no finasteride?)

in Treatment 5 upvotes 8 months ago

The user is using minoxidil and recently started fluridil for mild hair loss and is questioning if this treatment is sufficient without finasteride. They have finasteride available but prefer not to use it.

community Update: 16 months deep - big 3

in Progress Pictures 407 upvotes 1 year ago

The user has seen positive results after 16 months of using topical Finasteride/Minoxidil, microneedling weekly, and Tretinoin for hair loss. There are no reported side effects, and the user advises that the effectiveness of microneedling depends on the pressure applied.

community About 1 year of progress: Fin / Min / Microneedle / Nizoral

in Progress Pictures 158 upvotes 1 year ago

The user "BigBashMan" shared their progress pictures of hair regrowth after using a regimen of finasteride, minoxidil, microneedling, and Nizoral shampoo for about a year. They are happy with the results and attribute the microneedling as a potential factor for regrowth. Another user commented that they may see complete scalp coverage in another year.

community Study Shows That Oral Minoxidil Is Not Only Good At Improving Hair But Also Reducing Arterial Stiffness And Preventing Other Health Problems

in Minoxidil 22 upvotes 3 years ago

Oral minoxidil may improve hair growth, reduce arterial stiffness, and prevent other health issues. Some users believe it is an effective treatment despite concerns about its effects on skin and blood.

community My DHT levels have increased after taking 0.25mg Fin for 47 days!

in Finasteride/Dutasteride 184 upvotes 2 weeks ago

A user experienced increased hair shedding and unchanged DHT levels after taking 0.25mg of finasteride for 47 days, leading them to increase the dose to 0.5mg. Others discussed varying experiences with finasteride, minoxidil, and the importance of measuring scalp DHT.

community What the hell happened in my family genes?

in Chat 116 upvotes 5 months ago

A user is frustrated about early balding despite older male relatives retaining hair into old age. Another user plans to start finasteride soon to address their hair thinning.

community Currently crushing 3 (5mg) tablets of fin into my topical min. Anyone do the same? If so how much do you add.

in Treatment 186 upvotes 6 months ago

The conversation discusses using crushed finasteride tablets mixed with topical minoxidil for hair loss treatment. Users share their experiences and opinions on the effectiveness and proper concentration of this method.

community Finasteride gains continue well into year 5

in Chat 118 upvotes 6 months ago

Finasteride can continue to improve hair loss for up to 10 years, with the best results seen when started early. Combining treatments like minoxidil, dermarolling, or RU58841 may enhance effectiveness.

community [SAD UPDATE] 11 Months Topical Finasteride on TrichoSol - Hair got worse - Need Opinions

in Progress Pictures 9 upvotes 7 months ago

A user expressed disappointment that their hair loss worsened after 11 months using topical finasteride with TrichoSol, despite no side effects and initial signs of improvement. They asked for advice and opinions on their treatment and alternatives, with suggestions including switching to oral finasteride or dutasteride, starting minoxidil, and addressing their seborrheic dermatitis with different shampoos or medical advice.

community Finasteride increase in Estradiol?

in Update 17 upvotes 9 months ago

A user experienced increased estradiol, nipple tenderness, and ED after taking finasteride. They are considering dose reduction to mitigate these effects.

community how does my progress look 18M 3 months on fin 1mg daily

in Progress Pictures 277 upvotes 1 year ago

An 18-year-old male's successful hair regrowth after three months of using finasteride 1mg daily. He reported no side effects and other users expressed admiration and curiosity about his results.

community If you are a young guy worrying about hairloss

in Shaved/buzzed 161 upvotes 1 year ago

A 26-year-old man embraced baldness, gaining confidence and personal growth, and encourages self-acceptance. Others discussed hair loss treatments like Minoxidil and finasteride, but he did not use them.

community Why am I significantly losing ground even though I am constantly adding to my stack?

in Is this regrowth? 18 upvotes 1 year ago

The user is experiencing significant hair loss despite using treatments like finasteride, minoxidil, dutasteride, micro-needling, rosemary oil, and various vitamins. In the conversation, others suggest checking iron and hemoglobin levels, maintaining a positive attitude, and adding RU58841 to the treatment regimen.

community What an amazing time to be alive

in Finasteride/Dutasteride 184 upvotes 1 year ago

The post discusses a user's experience with hair loss treatments, specifically topical finasteride, minoxidil, and micro-needling, and their plan to switch to oral versions and add Dutasteride. The conversation includes various responses, with some users sharing their own experiences and side effects, and others expressing desire for a more permanent hair loss solution.

community [M30] 15 months progress on Oral Dutasteride and Sublingual Minoxidil

in Progress Pictures 237 upvotes 1 year ago

User shared 15-month progress using Oral Dutasteride and Sublingual Minoxidil for hair loss. Treatment improved hair density, now considering hair transplant with fewer grafts.

community Diagnosed with MPB. Started with finastride 1mg

in Finasteride/Dutasteride 18 upvotes 1 year ago

A 28-year-old male diagnosed with Male Pattern Baldness is using finasteride 1mg and asking if it's sufficient without minoxidil, PRP, or multivitamins. The advice given is to continue with finasteride and assess results after a year before considering additional treatments.

community 3 years fighting hairloss update

in Update 123 upvotes 3 years ago

Hair loss journey over 3 years, finasteride successful. Importance of positive mindset discussed.

community My personal results (M/25) 0.5mg Fin daily, Min foam once a day (in the evening) and Keto Shampoo twice a week. The before photo was taken in 2019 as I didn't plan to document the progress.

in Progress Pictures 922 upvotes 3 years ago

User shared personal hair loss treatment results using 0.5mg Fin daily, Min foam once a day, and Keto Shampoo twice a week. Significant improvement was observed, with others impressed and asking questions about the treatment.