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GlossaryTopical JAK Inhibitors

medications applied to skin to block Janus kinase enzymes

Topical JAK Inhibitors, also known as Topical Janus Kinase Inhibitors or Topical JAKis, are medications applied directly to the skin to block the activity of Janus kinase enzymes. These enzymes play a role in the immune response and inflammation. By inhibiting them, these treatments can help manage conditions like alopecia areata, an autoimmune disorder that causes hair loss, by reducing inflammation and potentially promoting hair regrowth.

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community TE turned into Scarring hairloss

Cheap-Adeptness3184 in Update 12 upvotes 11 months ago

The user experienced hair loss due to a crash diet and later developed scarring hair loss. They are now on finasteride, oral minoxidil, LDN, Zyrtec, and Oztela to reduce scalp inflammation and promote hair regrowth.

community Minoxidil can prevent hair follicle miniaturization!?

Ambush995 in Minoxidil 6 upvotes 3 years ago

Minoxidil can prevent hair follicle miniaturization, not just stimulate hair growth. Finasteride and dutasteride don't work for everyone, suggesting DHT may not be the sole cause of hair loss; hair loss could be due to multiple factors, including autoimmune conditions.

community 2020 Hair and Scalp Treatments: A Clinical Guide (in Depth 350 Page Guide)

TerpsandCaicos in Treatment 64 upvotes 5 years ago

Treatments for hair loss, including topical immunotherapy, regenerative treatments, laser and light-based therapies, oral supplements, intralesional steroids, and new drugs like finasteride and minoxidil.

community What else is good. Besides the big 3.

Ill-Passenger-2468 in Chat 34 upvotes 4 months ago

Key treatments for hair preservation include minoxidil, finasteride/dutasteride, and microneedling, with additional options like specific shampoos, oils, biotin, zinc, tretinoin, clascoterone, and low-level laser therapy. Maintaining a healthy lifestyle, reducing stress, and addressing nutrient deficiencies can also support hair health.

community Has anyone hear of the drug called Xeljanz?

pacer911 in Question 3 upvotes 8 years ago

The conversation discusses hair loss treatments, specifically mentioning Minoxidil, finasteride, RU58841, and Xeljanz. The user inquires about Xeljanz and shares a link suggesting it may help with hair loss.

community UPDATE: The theory that explains everything. Please help me make this big!

joaopassos4444 in Research/Science 448 upvotes 3 years ago

Hair loss theory involves 3alpha-hydroxysteroid reductase (3AHD) converting DHT to androstenol. Discussion explores potential treatments and encourages more research.

community Boys I am just a gonner. What on earth is my scalp even going through. Looks like world war 3. Pyril 3 months. Topical melitonin/progesterone/fin, dut, fin, oral min, laser trash, anus stimulation. Nothing. Donor area is decimated 😂.

Combfromhell in Progress Pictures 83 upvotes 2 years ago

Treating Seborrheic Dermatitis, a fungal scalp condition which can cause hair loss. Treatments discussed include antifungal shampoos, cold showers, exfoliating the scalp, taking Vitamin D, and stimulating the prostate through the anus.

community Hair came back in 3 months at 39y/o.

Quirky-Ingenuity3474 in Progress Pictures 421 upvotes 1 year ago

A user shared their successful hair regrowth using a combination of minoxidil, caffeine, biotin, and RU58841, along with weekly dermarolling. However, others advised against the user's plan to switch to rosemary oil and microneedling only, emphasizing the importance of continuing the current treatment to maintain the results.

community My experience and a discourse on “DUPA”

handalato in Chat 46 upvotes 2 years ago

How diffuse unpatterned alopecia (DUPA) is not an invitation to self-diagnose oneself with aggressive AGA and that seeking a specialized dermatologist may help people experiencing hair loss. Treatment options discussed include topical clobetasol propionate, oral minoxidil, and discontinuing finasteride.

community The Worst Hair Loss Condition You (MAY) have: LPP

noeyys in Research/Science 43 upvotes 5 months ago

Lichen Planopilaris (LPP) is an autoimmune condition causing permanent hair loss and fibrosis, often misdiagnosed. Treatments include pioglitazone, topical corticosteroids, anti-inflammatory medication, and Jak inhibitors.

community DUPA - 20 YO - Non responder to everything

PuzzleheadedArmy7081 in Finasteride/Dutasteride 13 upvotes 4 months ago

A 20-year-old user experienced worsening hair loss despite using various treatments including topical and oral minoxidil, finasteride, and dutasteride. Other users suggested additional treatments like JAK inhibitors, RU58841, and lifestyle changes, but the user remains skeptical and frustrated.

community Big sheeding after 9 months on minoxidil. Maybe caused by switching brands?

UnderstandingRich214 in Minoxidil 133 upvotes 1 year ago

A user experienced significant hair regrowth using Minoxidil but started shedding hair after switching brands and adding treatments like Topical Finasteride and microneedling. They also faced increased hair loss after using Ketoconazole shampoo and are seeking advice on whether brand switching or the shampoo could be the cause.

community M24 Finasteride (4M) minoxidil (2Y)

FalseHour6541 in Progress Pictures 57 upvotes 1 year ago

FalseHour6541's two-year experience with Minoxidil and Finasteride, resulting in good density on their crown; other users suggested a hair transplant to help reduce the receding hairline.

community If RU58841 is such an effective anti androgen

ConsistentLab193 in Research/Science 46 upvotes 1 year ago

RU58841 is discussed as a topical anti-androgen for hair loss, but its effectiveness and safety are not well-documented, leading to mixed opinions and experiences among users. Some combine it with finasteride, but concerns about side effects and lack of FDA approval limit its popularity.

community I am a dermatologist with a clinical interest in alopecia. AMA

4990 in Will treatment work for me? 2 years ago

In this conversation, 4990 discussed various treatments for hair loss, including oral minoxidil, PRP, transplan, Jak inhibitors, Dutasteride, Finasteride, Olumiant, Ketoconazole, RU58841, microneedling, baricitinib, and CCCA. They recommended scalp biopsies in unclear cases of DUPA, twice weekly to twice daily shampooing for topical minoxidil users, and two sessions spaced one month apart with follow up at month three to determine the effectiveness of PRP treatment.

community MBP Itch CURE?/ Slow shedding TBD

tuc71987 in Question 8 upvotes 5 years ago

A user with diffuse hair loss for a decade tried various treatments, including LLLT Helmet, supplements, topicals, and hair transplants. They found relief from scalp inflammation and itching using a topical solution made from crushed Xeljanz pills mixed with ethyl alcohol.

community If follicles became miniaturized and haven’t grown in 3 years, are they dead ?

Happy-Investigator- in Chat 2 years ago

Hair loss and its potential treatments, such as minoxidil, finasteride, RU58841, dermarolling, and supplements. It discusses whether miniaturized follicles can be revived to grow again or must shed for new growth to appear.

community Rare Non responder to Finasteride, Dutasteride, and oral minoxidil

hairthishairthat in Minoxidil 78 upvotes 11 months ago

A user did not respond to finasteride, dutasteride, and oral minoxidil for hair loss after four years of treatment and is considering scalp micropigmentation (SMP). Other users suggest the hair loss pattern may indicate alopecia areata and recommend seeing a dermatologist.

community One+ year 1mg Fin, Ketoconazole, and 3.75 Oral Min. I have DUPA. Switched from Topical to Oral Min.

Rubicant112 in Progress Pictures 142 upvotes 2 years ago

A user's experience with hair loss treatments such as finasteride, ketoconazole, and oral minoxidil that have not yielded any results; other users suggest shaving the head or getting a wig, while others offer additional advice such as seeing a dermatologist, checking thyroid levels, switching to dutasteride and adding needling, and trying stemoxydine.

community DHT blocking ingredients

jaycool812 in Treatment 6 upvotes 3 years ago

The conversation discusses DHT blocking treatments for hair loss, specifically mentioning Minoxidil, Finasteride, and organic flaxseed oil containing omega-3 fatty acids. It highlights skepticism about alternative treatments and emphasizes the proven effectiveness of Finasteride and Dutasteride.

community find a cure for this shit already

weareallfcked in Chat 207 upvotes 4 years ago

Treatments used to prevent and treat male pattern baldness, the difficulty in finding a permanent cure for hair loss, and the potential financial motivations of companies not wanting to find a cure.

community Best brand of topical melatonin?

Relevant-Exam6141 in Product 7 upvotes 2 years ago

People are using topical melatonin for diffuse thinning and retrograde alopecia. They are discussing the best brands and application methods.

community any news about DUPA (Diffuse unpatterned alopecia)?

GoodHair8 in Research/Science 11 upvotes 2 years ago

The conversation discusses diffuse unpatterned alopecia (DUPA) and its possible causes, including sensitivity to DHT, not being androgenic alopecia, being diffuse alopecia areata, or hormonal issues. Treatments mentioned include topical melatonin, Clobetasol Propionate for alopecia areata, and the lack of results from using finasteride, dutasteride, and minoxidil.

community Should I get transplant #4 or just shave my head?

irani_89 in Transplants 170 upvotes 6 months ago

A 36-year-old considering a fourth hair transplant is advised to either shave his head or use a hair system due to poor results from previous transplants and late medication use. He plans to consult top surgeons and adjust his current treatments, including finasteride and minoxidil.

community A hill on which I will die: The DHT itch absolutely exists

SigmaReductase in Research/Science 211 upvotes 8 months ago

The DHT itch is linked to hair loss and persists despite finasteride use; switching to dutasteride helped alleviate the itch and promoted regrowth. Some users suggest seborrheic dermatitis as a cause and recommend treatments like medicated shampoos, vitamin D, and minoxidil.

community Update on hair, will be posting monthly! Nov 8 – Jan 14

Hairevrywherebuthead in Progress Pictures 334 upvotes 2 years ago

A user's progress with treating their hair loss, including using finasteride, minoxidil, retinoic acid, dermapenning twice weekly and ket 2% shampoo two to three times per week. Other users offered advice such as not derma penning too often or shaving the area bald for a couple of months.

community maybe some of you need to hear this

Curious-Elk1638 in Chat 326 upvotes 2 years ago

Coping with hair loss, the effects of finasteride and minoxidil, and strategies for maintaining self-esteem while experiencing hair loss.

community Is it ok to take Xeljanz (A jak inhibitor) while taking finasteride?

Trowawaycausebanned4 in Finasteride 2 upvotes 7 years ago

The conversation is about whether it is safe to take Xeljanz, a JAK inhibitor, while also taking finasteride for hair loss. The concern is that Xeljanz weakens the immune system, which could be risky.

community I think it’s time to drop Pyrilutamide at this point?….

Number_Worried00 in Update 29 upvotes 1 year ago

A user who has been using Pyrilutamide for 5 months with no results, and other users suggesting they switch to RU58841 or stick to their treatment plan for at least one year.

community I’ve been on dutesteride and oral minoxidil for two years now and I’ve only lost ground…

flummoxed_pegasus in Treatment 42 upvotes 11 months ago

A user on dutasteride and oral minoxidil for two years reports worsening hair loss and is seeking advice. Suggestions include consulting a professional for underlying causes, acknowledging that treatments don't work for everyone, and considering dosage adjustments or additional treatments.