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GlossaryThyroid Hormone Receptors

proteins in cells that bind thyroid hormones to regulate genes

Thyroid Hormone Receptors (THRs) are proteins found in cells that bind to thyroid hormones, which are crucial for regulating metabolism, growth, and development. When thyroid hormones attach to these receptors, they influence the expression of specific genes, thereby affecting various physiological processes. This interaction is essential for maintaining normal metabolic function and can impact conditions like alopecia if disrupted.

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community Phase II for Technoderma Therepeutic's TDM-105795 set to begin in April tentatively

megaman2500 in Research/Science 41 upvotes 1 year ago

Phase II for TDM-105795 for Androgenic Alopecia is set to begin in April 2023. The study aims to evaluate the efficacy and safety of TDM-105795 in male subjects.

community Finally decided to buzz my head after experiencing hair loss since I was 17 (23 now). I think it looks decent, swipe to see what I was rocking before during the pandemic. Who knows maybe I’ll hop on fin but as someone who struggles with chronic fatigue and low test I’m hesitant.

JudoExpert in Shaved/buzzed 326 upvotes 2 years ago

A user's decision to shave their head after experiencing hair loss since the age of 17, and discussion around the potential use of Fin for treating hair loss.

community Please stop looking for a natural way to stop your hairloss

OnceIFuckHerIDuckHer in Chat 247 upvotes 2 years ago

There is no natural way to stop hair loss; pharmaceuticals like minoxidil, finasteride, and RU58841 are the only effective treatments. Some users report success with minoxidil and microneedling, while others discuss the side effects of finasteride.

community What other factors than DHT causes hair loss – and what to do about it?

domsolanke in Treatment 2 years ago

Factors that can cause hair loss other than DHT, such as inflammation and diet, and potential treatments like scalp massages, minoxidil, citrulline, stretches, meditation, iron sulfate/Vitamin C, Vitamin D, protein and Dutasteride.

community 8 months apart on the mother of all stacks

Tricky9555 in Progress Pictures 149 upvotes 1 year ago

User Tricky9555 tried various hair loss treatments for 8 months with no visible results. Others suggested considering a hair transplant, checking thyroid levels, and being patient for up to 24 months for potential results.

community Phase II Clinical Trial for TDM-105795 started recruiting

SnooBooks5080 in Research/Science 23 upvotes 1 year ago

A Phase II clinical trial for TDM-105795 has started recruiting in the US, and it might be a promising treatment for hair loss. Many hair loss drugs, including this one, originate from China.

community I’ve been on dutesteride and oral minoxidil for two years now and I’ve only lost ground…

flummoxed_pegasus in Treatment 42 upvotes 11 months ago

A user on dutasteride and oral minoxidil for two years reports worsening hair loss and is seeking advice. Suggestions include consulting a professional for underlying causes, acknowledging that treatments don't work for everyone, and considering dosage adjustments or additional treatments.

community My Experience and a Discourse on "DUPA"

AsleepFigure2077 in Treatment 8 upvotes 8 months ago

The user discusses their hair loss experience, exploring various hypotheses including thyroid levels, vitamin D, DHEA, nutritional deficiency, diabetes, seborrheic dermatitis, lack of nutrition to hair follicles, chronic inflammation, female pattern hair loss causes, cortisol, and prolactin levels. They are currently using finasteride, beta-sitosterol, and have tried topical dutasteride and microneedling therapy.

community If RU58841 is such an effective anti androgen

ConsistentLab193 in Research/Science 46 upvotes 1 year ago

RU58841 is discussed as a topical anti-androgen for hair loss, but its effectiveness and safety are not well-documented, leading to mixed opinions and experiences among users. Some combine it with finasteride, but concerns about side effects and lack of FDA approval limit its popularity.

community Take finasteride NOW. Life is short.

mantoosmall in Finasteride/Dutasteride 695 upvotes 3 years ago

User encourages taking finasteride for hair loss, stating rare permanent side effects. Replies discuss experiences with finasteride, side effects, effectiveness, and alternative treatments.

community If dutesteride and oral minoxidil doesn’t work that’s it right?

Loner_IRL in Treatment 41 upvotes 9 months ago

A user is experiencing ongoing hair loss despite using 0.5mg dutasteride and 2.5mg oral minoxidil for several years and is seeking advice. Suggestions include ensuring correct diagnosis, checking for other health issues, considering finasteride, trying topical antiandrogens, and consulting a dermatologist.

community How does hair loss and recovery work?

Throwaway_1606 in Chat 12 upvotes 5 months ago

Hair loss varies due to genetic sensitivity to DHT and other factors. Treatments discussed include finasteride, minoxidil, RU58841, and microneedling.

community Have we become too obsessed with DHT??

itsnearlygone in Chat 12 upvotes 3 years ago

Focus on scalp health, not just DHT suppression, is crucial for hair regrowth. Effective treatments include Hair Restoration shampoo, LLLT laser cap, microneedling, and topical finasteride.

community can someone please tell me its going to get better? im bawling my eyes out

youronyourownkid in Female 67 upvotes 2 years ago

A 16-year-old girl is experiencing hair loss, which has worsened despite using minoxidil and multivitamins. Suggestions include broader hormone testing and considering other treatments like spironolactone if the hair loss is due to androgenic alopecia.

community Update of my case, might have finally found what happened

Ok-Emu2477 in Minoxidil 6 upvotes 4 months ago

OP believes RU58841 affected their thyroid, causing hypothyroidism and impacting minoxidil's effectiveness. They plan to start thyroid medication to improve hair regrowth.

community 5 years of min / finasteride, no longer slowing loss.

Salines_Beach in Finasteride/Dutasteride 37 upvotes 2 years ago

A user's experience of slowing hair loss while taking minoxidil and finasteride, and the various treatments suggested to help halt or reverse the process.

community High Estrogen causing hair loss?

playeleventimes11 in Treatment 15 upvotes 1 year ago

A 24-year-old male using topical finasteride for hair loss is experiencing thinning despite treatment and has high estrogen levels. He is seeking advice on whether high estrogen could be causing hair loss and how others with high estrogen levels have addressed it.

community I rather have receding temples than diffused thinning all over

AfterHighlight9327 in Chat 102 upvotes 3 years ago

User with diffused thinning hair prefers receding temples, as hair transplant could fix it. Finasteride and minoxidil suggested to improve hair density.

community Pyrilutamide - your experience?

throwaway93047 in Product 12 upvotes 2 years ago

The conversation is about the lack of improvement in hair loss after using Pyrilutamide for 14 weeks, with the original poster unable to use Finasteride due to depression. Replies suggest that Pyrilutamide, like RU58841, may not work for everyone, and a more potent drug is being developed by Kintor.

community No regrowth after oral min, topical fin, min, and tret: Aggressive diffuse/hairline recession in 2 years

Personal_Dinner8424 in Is this regrowth? 118 upvotes 5 months ago

A user experienced no hair regrowth after using oral minoxidil, topical finasteride, minoxidil, and tretinoin, and reported side effects from oral finasteride. They are considering switching to dutasteride or using hair fibers for better results.

community Next month marks 2 years on Dutasteride. When does it start working?

Foreign_Fondant_2880 in Finasteride/Dutasteride 36 upvotes 8 months ago

A user has been on dutasteride for nearly 2 years with no improvement in hair loss, expressing frustration. Other users suggest checking for other health conditions, getting bloodwork, and considering stopping TRT or trying finasteride.

community Dutasteride SAVES your hair follicles: MAJOR BS on people who say it destroyed their hair permanently.

noeyys in Finasteride/Dutasteride 160 upvotes 1 year ago

The conversation discusses the effectiveness of hair loss treatments, specifically finasteride and dutasteride. The conclusion is that dutasteride significantly reduces DHT levels and may be more effective than finasteride for long-term hair retention, with some users reporting personal experiences and side effects.

community I’m on a crazy hairloss stack and I’m still losing hair and not experiencing any regrowth. What is going on?

United_Citron8474 in Treatment 29 upvotes 8 months ago

The user is using a combination of hair loss treatments including finasteride, stemoxydine, oral minoxidil, RU58841, dermastamping, ketoconazole shampoo, collagen, Viviscal, and biotin, and has improved their diet. Despite these efforts, they are still experiencing hair shedding and scalp itchiness, and are considering increasing their minoxidil dosage or starting dutasteride.

community Lost density 60% all over scalp in 120 days (4months)

Informal_Row6844 in Update 10 upvotes 8 months ago

A user lost 60% hair density in 4 months, started finasteride and microneedling, and has greasy, flaky, yellowish scalp. They are awaiting biopsy results, and another user suggested trying ketoconazole shampoo.

community Hey guys I’m a Compounding Pharmacist specialized in Hair-loss who makes Topical Finasteride Foam +/- minoxidil

Wonderful_Tea_1185 in Treatment 28 upvotes 3 years ago

A compounding pharmacist offers affordable topical finasteride foam with Anagain and micro-dose finasteride capsules for hair loss. They provide telehealth services across Canada and private appointments for international patients.

community Topical fin/min + microneedling 3 month results

BocaMurio0912 in Progress Pictures 33 upvotes 2 weeks ago

The conversation discusses hair loss treatments, specifically using topical finasteride and minoxidil combined with microneedling, along with supplements like collagen, vitamin C/D, and saw palmetto. The user also mentions using a DHT-blocking shampoo and experimenting with cold showers and contrast therapy for hair health.

community I really hate how current hair loss treatment only rely on DHT blockers

Significant_Web1562 in Finasteride/Dutasteride 76 upvotes 1 year ago

The conversation discusses dissatisfaction with current hair loss treatments that mainly focus on DHT blockers like finasteride and dutasteride. Alternative treatments mentioned include RU58841, pyrilutamide, minoxidil, rosemary oil, and future possibilities like hair cloning.

community Hair much worse after 6 months?

Copy_Successful in Progress Pictures 230 upvotes 1 year ago

A user experienced significant hair loss after 6 months of using 0.5mg finasteride daily. Suggestions from others included trying Dutasteride and Minoxidil, getting professional help from a dermatologist, and addressing high iron levels that could be contributing to the hair loss.

community Spironolactone for 11 years, finasteride for almost 5 years, started oral minoxidil in November 😢 ended oral contraceptive in Dec.

Lucbabino in Progress Pictures 224 upvotes 10 months ago

A user shared their 11-year experience with spironolactone and nearly 5 years with finasteride for hair loss, recently adding oral minoxidil and stopping birth control. Various treatments were discussed, including organic options, checking for underlying health issues, considering dutasteride, and the potential role of progesterone in hair loss.

community Why does finasteride stop working?

Extension-Tip-6536 in Finasteride/Dutasteride 26 upvotes 3 months ago

Finasteride may seem less effective over time due to increased DHT sensitivity or aging, but it still suppresses DHT. Switching to dutasteride offers stronger DHT suppression but may increase estrogen levels.