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GlossaryOral Retinoids (Systemic Retinoids)

medications derived from vitamin A for severe skin conditions

Oral retinoids are a class of medications derived from vitamin A, used to treat various skin conditions, including severe acne and psoriasis. They work by regulating cell growth and differentiation, which can help reduce inflammation and promote healthier skin. These medications can have significant side effects, so they are typically prescribed under strict medical supervision.

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community Hair shed after adding tretinoin with topical minoxydil

in Minoxidil 3 upvotes 3 weeks ago

Adding tretinoin to a minoxidil routine can cause initial hair shedding, which may be normal as it potentially increases minoxidil's efficacy. Users suggest being cautious with tretinoin application, especially around microneedling, to avoid increased systemic absorption.

community Correlation between topical retinoids and diffuse hair loss

in Research/Science 7 upvotes 2 years ago

Excess Vitamin A and topical retinoids can cause diffuse hair shedding. The user suspects their chronic telogen effluvium may be linked to using adapalene, a topical retinoid.

community A Nuanced Look at Microdosing Topical Finasteride

in Finasteride/Dutasteride 86 upvotes 1 year ago

The conversation discusses using a low dose of topical finasteride to achieve hair benefits with minimal systemic exposure. Users share experiences and opinions on dosing, systemic buildup, and side effects of both topical and oral finasteride.

community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 4 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community Dermatologist didn’t want to write for Dutasteride and oral minox, instead gave me script for this 12.5% minox with tretinoin,azelaic acid, and topical finasteride. It’s 55$ a month, is it worth it?

in Finasteride/Dutasteride 7 upvotes 2 years ago

The conversation discusses a prescribed hair loss treatment combining 12.5% minoxidil with tretinoin, azelaic acid, and topical finasteride, costing $55 a month. One user criticizes the packaging for degrading tretinoin, another suggests it's an overpriced option and recommends topical dutasteride as an alternative due to its higher molecular weight and lower systemic absorption.

community Can we once and for all clarify whether tretinoin helps or hurts hair?

in Treatment 41 upvotes 4 years ago

Tretinoin's effect on hair loss is debated; some say it improves minoxidil's effectiveness, while others claim it causes hair loss. Treatments discussed include tretinoin, minoxidil, finasteride, RU58841, and dermarolling.

community Where do you get tretinoin? without prescription? in Europe?

in Treatment 1 upvotes 1 month ago

The conversation discusses obtaining tretinoin without a prescription in Europe and its use to enhance minoxidil absorption for hair loss treatment. Users share sources, experiences, and application methods for tretinoin, with some noting side effects like increased shedding.

community Spironolactone topically with a try ?!

in Research/Science 1 upvotes 10 months ago

A 30-year-old male is considering using dutasteride and fluridil for hair loss maintenance and is curious about the effectiveness of topical spironolactone, as he cannot take finasteride. He is also planning a hair transplant.

community 22M After 3 years of minox and almost 2 on fin, I've got a NW1 and my ideal hair... but my face is fucked/aged from minoxidil and I want to stop it

in Minoxidil 9 upvotes 4 months ago

A user reported significant facial aging after using minoxidil for hair loss, despite a good skincare routine and healthy lifestyle. They plan to switch to dutasteride and possibly stop minoxidil.

community Progress since may 27, 2021. HairCAFE routine, DUT 3 times a week, topical minoxidil/tretinoin at night, topical stemoxydine and alfatradiol 50/50 mix with tretinoin in the morning.

in Progress Pictures 25 upvotes 3 years ago

User started DUT 3 times a week, topical minoxidil/tretinoin at night, and topical stemoxydine/alfatradiol mix with tretinoin in the morning for hair loss. They experienced significant progress and no side effects, crediting a YouTuber for encouragement.

community Collagen/Vitamins/Supplements and skin-care routine while on Minoxidil?

in Minoxidil 29 upvotes 4 years ago

Minoxidil users discuss skin-care routines to counteract side effects like dark circles and dull skin. Recommendations include vitamin C, potassium, collagen, retinol, nizoral shampoo, and emu oil.

community Why I Will be Accepting Baldness

in Chat 204 upvotes 1 year ago

User decides to accept baldness due to mental health issues with finasteride. Others suggest considering hair systems, topical finasteride, or RU58841 as alternatives.

community Why do I see so many people here recommend microneedling?

in Microneedling 105 upvotes 1 year ago

The efficacy of microneedling for hair regrowth as either a stand-alone therapy or adjunct to Minoxidil, and whether Tretinoin is a safer and more effective option. Replies include personal accounts from users who have had success with microneedling in combination with minoxidil and peptide serums, as well as considerations of technique, depth, and potential scarring.

community NW4 -> NW 2.5 (2.5 months progress) RU 8.5-9% ED and topical Dut .1% + RU 5% once a week.

in Progress Pictures 108 upvotes 1 year ago

User shows hair loss progress from NW4 to NW2.5 in 2.5 months using RU 8.5-9% daily and topical Dut .1% + RU 5% weekly. Discussion includes managing tension in African American hair and representation of different hair types.

community Oral minoxidil is not good for your health, let’s use research chemicals bought from AliExpress

in Satire 551 upvotes 1 year ago

. This conversation discussed the efficacy of Minoxidil and Finasteride as treatments for hair loss, with a focus on the potential side effects of taking Oral Minoxidil. Some users shared their experiences with both treatments and there was debate over whether they were safe or not.

community UPDATE: The theory that explains everything. Please help me make this big!

in Research/Science 449 upvotes 3 years ago

Hair loss theory involves 3alpha-hydroxysteroid reductase (3AHD) converting DHT to androstenol. Discussion explores potential treatments and encourages more research.

community 8 months - 0.5mg dut, 80mg Ru58841, 5mg oral min, topical min at night, microneedle 1.5mm every other week

in Progress Pictures 400 upvotes 1 year ago

The conclusion of the conversation is that the user has experienced significant hair regrowth using a combination of medications, including dutasteride, RU58841, and minoxidil. They have not experienced any noticeable side effects and are considering a hair transplant in the future.

community Switched to a once per day 7% min, 0.15% fin product. Is this a good idea? I'm a week and a half in and second guessing myself. No side effects.

in Finasteride/Dutasteride 1 upvotes 3 months ago

A 59-year-old male switched to a once-daily treatment of 7% Minoxidil, 0.15% Finasteride, and other ingredients, questioning its effectiveness compared to his previous twice-daily regimen. He has seen some hair regrowth but is unsure if the new treatment is better.

community Topical tretinoin increases minoxidil absorption by 3x. Thoughts?

in Minoxidil 39 upvotes 5 years ago

Topical tretinoin can increase the absorption of minoxidil by three times, which may enhance its effectiveness for hair loss treatment. Tretinoin causes increased skin turnover, making the skin more permeable and potentially improving minoxidil's efficacy.

community Topical Finasteride Selection

in Finasteride/Dutasteride 1 upvotes 4 months ago

A user is seeking advice on choosing the right topical finasteride for hair loss, considering different formats (spray, gel, aqueous solution) and brands (Xyon, Ro, Keeps, Hims Rx Hair Loss Serum, Happy Head Topical Rx Serum). They are also concerned about the optimal strength to minimize side effects while using it with topical minoxidil.

community My progress for 1 year minoxidil and dutasteride mesotherapy

in Progress Pictures 101 upvotes 2 years ago

A user's progress using minoxidil and dutasteride mesotherapy to treat hair loss, with advice from other users on whether or not to continue the treatment. Suggestions included trying oral treatments such as finasteride and RU58841, and considering a hair transplant for more significant results.

community 5 month mark. Topical solution of fin/min/trentinoin. Micro needle once every 10 days and keto shampoo twice a week.

in Progress Pictures 726 upvotes 2 years ago

A user's 5 month progress with their hair loss treatment which includes topical finasteride and minoxidil, microneedling once every 10 days, and keto shampoo twice a week. Other users shared their own experiences and advice on treatments.

community Why does it seem everyone favors finasteride over dutasteride?

in Female 62 upvotes 7 months ago

The conversation discusses preferences for hair loss treatments, specifically finasteride over dutasteride. Users share personal experiences, cost considerations, FDA approval status, and potential side effects, with some switching between treatments to find what works best for them.

community I’m already DOING EVERYTHING!!!

in Female 27 upvotes 3 years ago

A 26 year old female dealing with hair loss who is considering treatments such as Spiro, minoxidil and finasteride. Other potential solutions mentioned are PRP treatment, a wig, and bio-identical estrogen combined with bica.

community A Systemic Review on Topical Marketed Formulations, Natural Products, and Oral Supplements to Prevent Androgenic Alopecia: A Review

in Research/Science 6 upvotes 6 months ago

Topical formulations, natural products, and CAM therapies are being used to treat Androgenic alopecia to avoid side effects of Finasteride and Minoxidil. The review covers various low-risk, alternative treatment options.

community My Ultimate Hair Regrowth Regimen: Minimizing Systemic Exposure While Maximizing Results

in Research/Science 16 upvotes 3 months ago

The regimen includes using a diluted 5.5% Minoxidil / 0.025% Finasteride solution daily, microneedling weekly, and ketoconazole shampoo twice a week to minimize systemic exposure while maximizing scalp DHT reduction. The goal is to achieve hair regrowth with minimal side effects.

community If apply topical fin goes systemic then does it matter where I apply it on the scalp?

in Finasteride/Dutasteride 10 upvotes 7 months ago

The conversation is about whether topical finasteride and minoxidil need to be applied directly to the affected areas of the scalp or if they can be spread through blood vessels. It also asks how long topical finasteride remains on a pillow.

community Ru with gloves because of Systemic absorption?

in Research/Science 10 upvotes 1 year ago

The conversation is about whether to use gloves when applying 5% RU58841 to avoid systemic absorption and if washing hands with water is sufficient. Users question the concern, noting it is applied to the scalp.

community New systematic review on topical and systemic spironolactone (2023)

in Research/Science 7 upvotes 1 year ago

Hair loss treatments discussed include Minoxidil, Finasteride, and RU58841. Topical and oral spironolactone show potential in improving hair growth when combined with topical Minoxidil.

community Evidenced Based Meta-Analyses and Systemic Reviews of Androgenic Alopecia and Treatments

in Research/Science 14 upvotes 4 years ago

Evidence-based treatments for androgenic alopecia, such as minoxidil, finasteride, low-level laser light therapy, dutasteride, platelet-rich plasma, and topical ketoconazole. It discusses the efficacy, safety, and mechanism of action of these treatments, as well as future developments in understanding this polygenic condition.