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GlossarySulfotransferase

enzyme that attaches sulfate groups to other molecules

Sulfotransferase is an enzyme that adds sulfate groups to molecules, a process known as sulfation. This modification can change the function or activity of the target molecules, which often include hormones, drugs, and proteins. In the context of hair biology, sulfotransferases can influence hair growth and health by modifying signaling molecules involved in these processes.

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community Diffuse thinning is so brutal.

in Styling 72 upvotes 1 year ago

A 25-year-old with AGA experienced hair thinning and dandruff, stabilized with topical finasteride and minoxidil but saw minimal regrowth. They seek advice on styling and consider oral minoxidil and microneedling for denser hair.

community Minoxidil: Sulfotransferase Enzyme booster AVAILABLE NOW

in Minoxidil 7 upvotes 1 year ago

A new product, Minoxidil booster, which enhances sulfotransferase enzyme activity in the scalp, is now available. The user has started using this product, applied before Minoxidil, to improve their hair loss treatment results.

community What Determines Sulfotransferase Enzyme Levels In The Body?

in Minoxidil 7 upvotes 1 week ago

Some people have low sulfotransferase enzyme levels, affecting their response to minoxidil. Lifestyle factors, genetics, and diet, like MSM intake, might influence these enzyme levels.

community New hack? Tretinoin enhances minoxidil response in androgenetic alopecia patients by upregulating follicular sulfotransferase enzymes

in Research/Science 16 upvotes 2 years ago

The conversation discusses how Tretinoin may improve the effectiveness of Minoxidil for treating hair loss by increasing the activity of certain enzymes in hair follicles. One user comments that this information is not new.

community Minoxidil Non-responders: Have you tried Minoxidil Sulfate?

in Minoxidil 6 upvotes 7 years ago

Minoxidil non-responders may benefit from using minoxidil sulfate due to reduced sulfotransferase activity in their scalps. Users are encouraged to share their experiences with minoxidil sulfate.

community Minoxidil Sulfate makes everyone a responder

in Research/Science 257 upvotes 1 month ago

Minoxidil sulfate is more effective than regular minoxidil, especially for those with low sulfotransferase levels or scalp sensitivity, but it is unstable unless delivered in a liposomal format. Combining minoxidil with tretinoin can enhance effectiveness, and stopping minoxidil use can lead to rapid hair loss.

community Low-dose daily aspirin reduces topical minoxidil efficacy in androgenetic alopecia patients.

in Minoxidil 6 upvotes 5 years ago

Low-dose daily aspirin reduces the effectiveness of topical minoxidil in treating androgenetic alopecia. Aspirin inhibits sulfotransferase enzymes, which are necessary for minoxidil to work.

community Stop Using Salicylic acid on your face if using minoxidil for beard growth

in Product 20 upvotes 6 months ago

Salicylic acid can reduce the effectiveness of minoxidil for beard growth. Users discuss avoiding salicylic acid when using minoxidil.

community could Tretinoin alone cause regrowth?

in Treatment 7 upvotes 1 year ago

The user has maintained their hairline with finasteride for 5 years and saw no results from minoxidil. They are inquiring if tretinoin alone can cause hair regrowth.

community Topical minoxidil and salicylic acid

in Minoxidil 4 upvotes 4 months ago

The user has been using finasteride for 6 months with decent results and recently added topical minoxidil. They are concerned that salicylic acid in their skincare products might reduce minoxidil's effectiveness.

community Applying Tertinoin + Moisturiser on scalp.

in Chat 1 upvotes 5 months ago

A user is treating hair loss with oral finasteride, topical minoxidil, and tretinoin mixed with moisturizer for easier scalp application. They also plan to use a derma pen weekly.

community New Study Fails to Show Benefits of Microneedling in Males with Balding.

in Treatment 157 upvotes 1 year ago

A new study suggests microneedling alone doesn't benefit male balding, but users argue the study's methods differ from common practices, like combining microneedling with minoxidil and using more frequent treatments. Some believe the study's short duration and infrequent sessions are inadequate to assess microneedling's effectiveness.

community Tretinoin Efficacy Alone for Hair Regrowth + DHT blocker

in Minoxidil 5 upvotes 1 year ago

Tretinoin's effectiveness for hair regrowth alone is questioned, with interest in its use with oral minoxidil. The discussion also considers whether finasteride or dutasteride is the better DHT blocker and if switching to dutasteride is advisable for those without side effects from finasteride.

community Could microneedling for the next 5 years cause any permanent damage?

in Microneedling 22 upvotes 1 year ago

Microneedling for hair loss and its potential long-term effects. Some users believe it can cause fibrosis and scar tissue if done too frequently or deeply, while others claim it has improved their hair loss when done correctly. There is limited scientific research on the topic.

community Daily aspirin is ruining your Min. gains

in Minoxidil 5 upvotes 1 year ago

Aspirin reduces the effectiveness of minoxidil for hair loss. Quercetin and 5-ASA medications also inhibit the necessary enzyme for minoxidil to work.

community any minox non-responders turn to good responders after adding microneedling or tretinoin?

in Minoxidil 7 upvotes 2 years ago

The conversation is about someone who initially had positive results with Minoxidil for hair loss, lost those gains due to a hospital stay, and is now not seeing the same results upon resuming treatment. They plan to add microneedling and/or tretinoin to their regimen and are seeking success stories from others who did not respond to Minoxidil alone.

community Any anecdotes about tretinoin and min?

in Minoxidil 7 upvotes 4 months ago

The conversation discusses the effectiveness of combining tretinoin with minoxidil for hair loss. The user notes better results from microneedling rather than the tretinoin and minoxidil combo.

community Minoxidil 5% + finestride 0.1% 3months Progress

in Progress Pictures 100 upvotes 7 months ago

User shared 3-month progress using Minoxidil 5% and Finasteride 0.1%, switching brands after the first month. Replies suggest the progress is good, with concerns about patches and shedding.

community Why isn’t oral minoxidil enough for me?

in Minoxidil 7 upvotes 9 months ago

A user takes 5mg oral minoxidil, oral dutasteride, topical tretinoin, stemoxydine, topical minoxidil, and uses dermarolling for hair loss but sees less impressive, patchy regrowth compared to others. Another person suggests some online results may be enhanced with hair fibers, not just medication.

community Why do I see so many people here recommend microneedling?

in Microneedling 104 upvotes 1 year ago

The efficacy of microneedling for hair regrowth as either a stand-alone therapy or adjunct to Minoxidil, and whether Tretinoin is a safer and more effective option. Replies include personal accounts from users who have had success with microneedling in combination with minoxidil and peptide serums, as well as considerations of technique, depth, and potential scarring.

community Any info on where to buy solution for diluting my topical solution from 1mg/ml to 1mg/2ml

in Treatment 7 upvotes 2 years ago

The user plans to make a hair loss treatment combining minoxidil, finasteride, and melatonin, and wants to dilute it for a larger coverage area. They are seeking advice on how to dilute the solution and where to purchase the diluting agent.

community Oral Minoxidil Experience (2 months, 1 week in)

in Minoxidil 6 upvotes 2 years ago

The user shared their experience with oral minoxidil for hair loss, noting initial shedding but some improvement in hair thickness and coloration. They also use dutasteride, RU58841, topical minoxidil, a laser hat, dermapen, Nizoral, caffeine shampoo, castor oil, vitamins, and MSM tablets.

community Tretinoin for increased minoxidil conversion

in Research/Science 10 upvotes 2 years ago

The conversation is about using Tretinoin with Minoxidil for hair loss treatment, discussing the effectiveness and personal experiences with different concentrations. The image linked in the post received negative reactions for being unpleasant.

community Have any minoxidil non-responders ever gotten results after adding stemoxydine?

in Minoxidil 9 upvotes 3 years ago

Hair loss discussion involves minoxidil, finasteride, and RU58841. Minoxidil non-responders may see results after adding stemoxydine due to increased enzyme presence.

community Anybody not respond to high % topical minoxidil, but did switching to oral?

in Minoxidil 8 upvotes 3 years ago

The conversation is about someone who did not see results from using 5%, 10%, and 12.5% topical Minoxidil for hair loss and is inquiring if switching to oral Minoxidil helped others who had a similar experience. They are asking for the dosage that was effective for those who saw results with oral Minoxidil.

community Study: minoxidil alone is just as effective as minox+tretinoin+azelaic acid

in Research/Science 18 upvotes 3 years ago

Minoxidil alone is just as effective as when combined with tretinoin and azelaic acid for hair loss. People adding tretinoin and azelaic acid to minoxidil may not see the expected benefits.

community Help : How to mix Tretinoin with Minoxidil?

in Research/Science 1 upvotes 1 month ago

The user is seeking advice on mixing 5% Minoxidil with 0.025% Tretinoin for hair loss treatment, as they cannot find a suitable product in India and are considering making it themselves. They express concerns about mixing ratios and stability, while others suggest applying them separately or mixing them with other ingredients like finasteride and RU58841.

community Is microneedling + minoxidil better than oral minoxidil

in Chat 29 upvotes 1 month ago

Oral minoxidil is considered more effective for hair regrowth than topical minoxidil, but it carries higher risks. Combining microneedling with topical minoxidil can enhance absorption, but oral minoxidil with microneedling shows significant results.

community Theory As To Why Oral Minoxidil Might Be Helpful To People Compared To Topical Minoxidil

in Minoxidil 8 upvotes 2 months ago

Oral minoxidil may be more effective than topical due to uniform distribution and systemic activation, but can cause side effects like puffiness. Adding tretinoin to topical minoxidil can enhance its effectiveness by aiding conversion to its active form.

community 4.5 month progress on oral Finasteride and topical Minoxidil

in Is this regrowth? 106 upvotes 4 months ago

A user shared their 4.5-month progress using oral finasteride and topical minoxidil for hair loss, noting some perceived improvement in the crown area. Other users encouraged them to continue the treatment.