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GlossarySkin Permeability

ability of substances to pass through skin layers

Skin permeability refers to the ability of substances to pass through the skin barrier. This is important for the delivery of medications through topical treatments and for understanding how chemicals in the environment can affect the body. Factors like the condition of the skin, the size and solubility of the substance, and the presence of enhancers or barriers can influence how easily substances penetrate the skin.

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community Tretinoin can enhance the skin permeability of Minoxidil approximately 3-fold at 0.05%[24] and itself has some hair regrowth properties.

7 upvotes 9 years ago

The conversation discusses enhancing Minoxidil absorption for hair loss treatment using Tretinoin and MSM (Methylsulfonylmethane). The user is seeking sources for Tretinoin and mentions MSM's potential to improve the absorption of topical agents.

community Sugars ARE important for hair growth | Glycosaminoglycans as Hair Growth Stimulant

in Research/Science 75 upvotes 4 months ago

Glycosaminoglycans are important for hair growth, and combining minoxidil with tretinoin and Biopeptide-CL may enhance hair growth by boosting glycosaminoglycan levels and improving the hair follicle environment. Users discussed the potential effectiveness and future of these treatments.

community Peptides that Stop Hair Loss? | In-depth Literature Review Video

in Research/Science 74 upvotes 5 months ago

Peptides like TB500, KPV, GHK-CU, and BPC-157 are overhyped for hair growth with limited proven effectiveness in humans. Combining peptides with delivery methods like iontophoresis and sonophoresis shows promise, but many claims remain unproven.

community Hair shed after adding tretinoin with topical minoxydil

in Minoxidil 3 upvotes 2 weeks ago

Adding tretinoin to a minoxidil routine can cause initial hair shedding, which may be normal as it potentially increases minoxidil's efficacy. Users suggest being cautious with tretinoin application, especially around microneedling, to avoid increased systemic absorption.

community could Tretinoin alone cause regrowth?

in Treatment 7 upvotes 1 year ago

The user has maintained their hairline with finasteride for 5 years and saw no results from minoxidil. They are inquiring if tretinoin alone can cause hair regrowth.

community to all people who cannot tolerate anti androgens (loe dose topical fin, pyrilutamide, CB) i am getting desperate, looking for a solution

in Research/Science 13 upvotes 1 year ago

The user tried Minoxidil without success, and Finasteride worked but caused sexual side effects even at a very low dose. They are seeking alternative treatments for hair loss as they cannot tolerate anti-androgens and are also in therapy for mental health.

community Sandalore: a scientific homemade approch

20 upvotes 6 years ago

The post discusses using Sandalore as a potential hair loss treatment, emphasizing precise measurements and safe handling. The user compares Sandalore's effects to Minoxidil and mentions preparing a solution with ethanol and DMSO.

community 9 months fin 0.33mg daily - everything’s coming up millhouse

in Progress Pictures 81 upvotes 1 year ago

User started oral finasteride 0.33mg daily and later made a topical solution with cetirizine and stemoxydine. They experienced hair growth progress after 8-9 months and discussed factors affecting their results.

community Impressed by the progress but think it’s time to go for the transplant?

in Progress Pictures 288 upvotes 10 months ago

The user started taking 2.5mg minoxidil tablets daily and reduced their finasteride dose to 0.5mg due to side effects. They are considering a hair transplant but are unsure if they should proceed now or wait after seeing the effects of the reduced finasteride dosage.

community Has anybody tried retinol (not Retin A aka tretinoin) combined with minoxidil?

in Treatment 20 upvotes 2 years ago

The conversation is about someone who had success using retinol with minoxidil for hair growth, but experienced shedding with Retin A (tretinoin). They are asking if others have tried retinol with minoxidil and what their results were.

community Wtf have we been doing for the last 30 years

in Treatment 501 upvotes 2 days ago

Hair loss treatments like finasteride, minoxidil, and dutasteride work but have side effects. A permanent cure is still not available due to the complexity of hair loss and limited investment.

community Finasteride can revive up to 7 year old dead hair

in Research/Science 188 upvotes 2 months ago

Finasteride and minoxidil can revive hair dormant for up to 7 years, with microneedling enhancing regrowth. Users report significant hair regrowth even after long periods of baldness.

community Topical finasteride now the safest possible path?

in Finasteride/Dutasteride 82 upvotes 5 months ago

Topical finasteride is considered a safer option for hair regrowth with fewer systemic side effects compared to oral finasteride. Some users report similar efficacy and side effects between topical and oral treatments, while others prefer topical due to reduced systemic exposure.

community I am a dermatologist with a clinical interest in alopecia. AMA

in Will treatment work for me? 2 years ago

In this conversation, 4990 discussed various treatments for hair loss, including oral minoxidil, PRP, transplan, Jak inhibitors, Dutasteride, Finasteride, Olumiant, Ketoconazole, RU58841, microneedling, baricitinib, and CCCA. They recommended scalp biopsies in unclear cases of DUPA, twice weekly to twice daily shampooing for topical minoxidil users, and two sessions spaced one month apart with follow up at month three to determine the effectiveness of PRP treatment.

community Kintor Pharma Announces Positive Top-line U.S. Phase I Trial Results of GT20029, the World’s First Topical Use PROTAC Compound

in Research/Science 126 upvotes 1 year ago

The conversation discusses positive initial trial results for GT20029, a topical compound for hair loss that degrades androgen receptors, potentially requiring only weekly application. Participants express hope for this treatment to be more effective and convenient than current options like Minoxidil, Finasteride, and RU58841.

community Skin, Hair, and Nails by Pharmekal withdrawn from the market

in Product 1 upvotes 1 year ago

Skin, Hair, and Nails by Pharmekal was withdrawn from the market. Users discuss alternative supplements and treatments like Minoxidil, finasteride, and RU58841.

community My skin is always dry and flakes like chalk (25)

in Transgender 6 upvotes 8 months ago

The user underwent a biopsy two years ago and was diagnosed with keratosis pilaris, leading to hair issues. They tried treatments including Minoxidil, betamethasone, lymecycline, topical Accutane, and dutasteride, as well as diet changes, without improvement in hair thickness or skin dryness.

community Personal Anecdote: Be careful with oral min, it can have a bad impact on your skin

in Minoxidil 4 upvotes 10 months ago

Oral minoxidil can cause skin issues like redness and bumps. The user saw no hair improvement with oral minoxidil but noticed increased facial hair.

community Androgenetic alopecia is a skin disease: DHT-mediated skin disorders

in Research/Science 65 upvotes 1 year ago

Dihydrotestosterone (DHT) impacts various skin conditions, including Androgenetic alopecia and seborrheic dermatitis, by causing overactivity in sebaceous glands. Topical medications Tacrolimus and Clobetasol can reduce these inflammatory conditions, and treatments like RU58841, Minoxidil, and Finasteride may also be beneficial.

community Anybody else notice improved skin/collagen on Dutasteride

in Finasteride/Dutasteride 6 upvotes 1 year ago

User switched from finasteride to combination dutasteride and finasteride for hair density improvement. They noticed less hair shedding and more youthful skin, with a reply suggesting less DHT could increase elastin in skin.

community Oral minoxidil can causes age skin?

in Minoxidil 8 upvotes 2 years ago

Oral minoxidil may cause skin aging, such as dark circles. To counteract aging, use tretinoin at night and broad-spectrum sunscreen during the day.

community Minoxidil and skin aging worry – which prevention methods (platelet rich plasma, microneedlig, mesotherapy, stem cells, co2, ultherapy, …)

in Chat 4 upvotes 2 years ago

User started minoxidil, noticed forehead lines and dark circles, and asked for non-invasive skin aging prevention methods. Another user suggested using tretinoin and hyaluronic acid for long-term benefits.

community Topical application of Apple Skin 15% Procyanidin B2 extract makes hair noticeably thicker

in Treatment 7 upvotes 2 years ago

Hair loss discussion includes homemade 15% Procyanidin B2 apple skin extract as alternative to Minoxidil. User reports thicker hair, but no new growth yet.

community Can Minoxidil be Aging My Skin?

in Minoxidil 6 upvotes 3 years ago

Minoxidil may cause skin aging effects like wrinkles and dark circles, but evidence is mixed. Alternatives like dermarolling and retinol are suggested.

community Collagen/Vitamins/Supplements and skin-care routine while on Minoxidil?

in Minoxidil 29 upvotes 4 years ago

Minoxidil users discuss skin-care routines to counteract side effects like dark circles and dull skin. Recommendations include vitamin C, potassium, collagen, retinol, nizoral shampoo, and emu oil.

community So does oral minoxidil age your skin or not

in Minoxidil 41 upvotes 8 months ago

Oral minoxidil may cause dry skin and dark eye bags but doesn't significantly age the skin. Topical minoxidil is toxic to cats, and some users prefer finasteride.

community Start taking care of your skin and hair loss TODAY! I was telling myself I didn’t care, but I think the difference in my facial expression says it all. Take action asap before more permanent damage is done. I hope I can inspire some of you, because it’s so worth it. Not for others, for yourself! <3

in Progress Pictures 583 upvotes 2 years ago

User shared progress in treating hair loss and improving skin, using treatments like finasteride, minoxidil, RU58841, tretinoin, microneedling, and skin care regimen. Others commented on the impressive results and asked about costs and side effects.

community For those of you who are getting facial skin side effects (aging, dark circles) from minoxidil, try this, it helped me.

in Minoxidil 11 upvotes 3 years ago

The conversation provides tips to reduce facial skin side effects from Minoxidil, such as changing pillowcases, sleeping on the back, careful application, hydration, and taking breaks. One reply suggests that alcohol in Minoxidil formulations, not Minoxidil itself, may cause skin aging.

community What's the consensus about Minoxidil and skin aging/effects?

in Minoxidil 7 upvotes 4 years ago

The conversation discusses concerns that Minoxidil may cause skin aging, like collagen depletion and puffier faces. Some users suggest that a good skincare routine or collagen supplements might prevent these effects.

community Low-dose oral minoxidil and skin aging

in Minoxidil 7 upvotes 5 years ago

The conversation discusses the use of low-dose oral minoxidil for hair loss and its potential effects on skin aging. Users shared experiences, with some noting side effects like puffy eyelids and dark circles, but no conclusive evidence of significant collagen depletion or increased wrinkles.