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GlossaryHypogonadotropic Hypogonadism (Secondary hypogonadism)

condition where low hormone signals from the brain reduce sex hormone production

Hypogonadotropic Hypogonadism (HH) is a condition where the gonads (testes in men and ovaries in women) produce insufficient sex hormones due to a problem with the hypothalamus or pituitary gland, which are responsible for signaling the gonads to function. This can lead to delayed puberty, infertility, and other hormonal imbalances.

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community Low normal DHT but still losing the hairs from the front scalp. Looking for suggestions on what treatment can be used to treat hair loss ?

in Research/Science 8 upvotes 1 year ago

A 31-year-old male with low normal-range testosterone and DHT is experiencing significant hair loss from the front scalp. He has tried Minoxidil, vitamin D3 and B12 supplements, and exercises regularly but is still seeking the root cause and effective treatment.

community 8 week - sharing Finasteride blood test update

in Progress Pictures 6 upvotes 1 year ago

A 32-year-old male started taking 0.5mg of finasteride daily for hair thinning and, after 8 weeks, experienced a 70% reduction in DHT and an increase in estradiol; he is currently in the shedding phase of treatment and questioning if the dosage is correct based on his DHT levels. He began with a lower dose due to already low normal testosterone and DHT levels.

community A systematic bro-science review of DHT, 5AR, neurosteroids, sexual health and 5AR inhibitors

in Research/Science 37 upvotes 2 years ago

Hair loss treatments, specifically 5AR inhibitors, can impact neurosteroids and sexual health. The effects of topical fin/dut on tissue-specific DHT levels are unclear.

community From the research study: "Dihydrotestosterone and the concept of 5a-reductase inhibition in human benign prostatic hyperplasia" - G. Bartsch, R.S. Rittmaster, H. Klocker (2002) in the "World Journal of Urology".

in Research/Science 23 upvotes 2 years ago

Dutasteride is a stronger 5AR inhibitor than finasteride and can significantly lower DHT levels. Reduced doses of dutasteride may lower side effects.

community Simple to add GHK-Cu to RU58841?

in Product 1 upvotes 3 weeks ago

The conversation is about a user seeking advice on adding GHK-Cu to RU58841 for hair loss treatment, while already using oral minoxidil, dutasteride, ketoconazole shampoo, and considering LLLT. They are unsure about the concentration and carrier solution for GHK-Cu.

community Is hydrocortisone that bad for your scalp?

in Minoxidil 1 upvotes 2 months ago

Hydrocortisone is not recommended for long-term use on the scalp due to potential side effects like thinning and steroid-related issues. Alternatives like foam minoxidil or oral minoxidil are suggested, though foam may be less effective.

community Has Saw Palmetto (or PSO) stopped my shedding?

in Treatment 6 upvotes 8 months ago

A user experienced hair shedding despite using natural remedies but saw improvement with topical finasteride and oral minoxidil. After stopping supplements like saw palmetto and pumpkin seed oil, shedding resumed, but combining them again with finasteride and minoxidil reduced shedding.

community Proposed new pathogenesis model for androgenetic alopecia (AGA)

in Research/Science 8 upvotes 1 year ago

The conversation discusses a new model for understanding androgenetic alopecia (AGA), linking it to dietary and lifestyle factors similar to PCOS, and highlighting the role of DHT, vascular damage, and inflammation. Treatments mentioned include Minoxidil, finasteride, and RU58841.

community It’s time for total war on hair loss.

in Treatment 26 upvotes 1 year ago

A user's experience with hair loss, their attempts to treat it using topical minoxidil and finasteride, and other suggested treatments such as oral minoxidil and finasteride. Replies included advice against wasting time or money on scalp massages or oils.

community M18 Is it smart to start with minox only?

in General 124 upvotes 2 weeks ago

An 18-year-old is considering starting minoxidil for hair loss due to a receding hairline but is hesitant about using finasteride due to age and lack of health insurance. A suggestion was made to use topical finasteride and minoxidil, along with lifestyle changes like exercise and cold showers.

community Male - 25 y.o - gulfs slowly fading like my father’s - topical minoxidil, soon starting fin + keratine supplement

in Journals / Progress Pictures 231 upvotes 5 months ago

A 25-year-old male is using topical minoxidil and plans to start finasteride and a keratin supplement to combat hair loss. He will document his progress with photos and track any side effects.

community Best shampoo and conditioner for hair loss

in Product 6 upvotes 6 months ago

The user is using minoxidil, finasteride, Nizoral 2%, and microneedling for hair loss but finds Nizoral drying. They seek affordable shampoo and conditioner recommendations, with one reply suggesting baby shampoo for non-Nizoral days.

community Progress from one year of finasteride only.

in Progress Pictures 561 upvotes 7 months ago

A 23-year-old man shared his one-year progress using finasteride for hair loss, starting with a lower dose due to side effects and gradually increasing to 1mg. He experienced manageable side effects and is considering adding minoxidil or switching to dutasteride in the future.

community my Body hair has stopped working

in Finasteride/Dutasteride 44 upvotes 10 months ago

A user on dutasteride for hair loss noticed hair regrowth on their head but a significant reduction in body hair growth. They plan to switch to finasteride and dutasteride and are considering testosterone replacement therapy but are concerned about its effects on hair growth.

community Impressed by the progress but think it’s time to go for the transplant?

in Progress Pictures 288 upvotes 10 months ago

The user started taking 2.5mg minoxidil tablets daily and reduced their finasteride dose to 0.5mg due to side effects. They are considering a hair transplant but are unsure if they should proceed now or wait after seeing the effects of the reduced finasteride dosage.

community It’s getting worse. (4 months)

in Update 203 upvotes 11 months ago

The conversation discusses hair loss treatments, with users suggesting the use of finasteride daily, considering minoxidil for aggressive hair loss, and discussing the normalcy of shedding during treatment. Some users recommend adding Nizoral shampoo and switching to dutasteride for better results.

community Phase 3 of pyrilutamide (kx-836) analysis of the efficacy

in Research/Science 11 upvotes 1 year ago

The conversation discusses the less impressive results of Pyrilutamide (kx-836) in phase 3 compared to phase 2, with a suggestion that a longer study might show more significant results. One user reports personal success with Pyrilutamide, experiencing no further hair loss and gradual regrowth.

community HMI-115 Australian Phase 1 Trial completed?

in Research/Science 20 upvotes 1 year ago

The post discusses the completion of the HMI-115 Australian Phase 1 Trial for hair loss treatment. The user speculates about the potential early release of the trial results.

community Which vitamin deficiencies can lead to hair loss?

in Chat 69 upvotes 1 year ago

The conversation discusses potential vitamin deficiencies leading to hair loss, with a focus on Vitamin D and iron. Some individuals are using finasteride and minoxidil for hair loss, while others consider vitamin supplementation due to deficiencies.

community How would you start your hairloss battle if you were 16 y.o?

in Treatment 15 upvotes 1 year ago

A 16-year-old experiencing hair loss seeks treatment advice. They decide to start with Serioxyl, Ketoconazole shampoo, and Eucapil, considering Minoxidil and Finasteride for later use.

community How long did it take for you to accept your hairloss?

in Chat 1 year ago

Accepting hair loss, and the use of medications such as finasteride, minoxidil, and microneedling to treat it. The responses provide advice and personal experiences related to coping with hair loss.

community So basically we will know the efficacy of HMI-115 in 3 months after the phase II study concludes in China?

in Chat 10 upvotes 1 year ago

Hair loss discussion mentions HMI-115 efficacy in 3 months after Phase II study. Users discuss treatment effectiveness and mention massive regrowth in previously bald areas.

community When will HMI-115 second trail be over?

in Research/Science 9 upvotes 1 year ago

A clinical trial for hair loss treatments involving Minoxidil, Finasteride, and RU58841, and when the results of the trial will be available.

community discouraged about pyrilutamide

in Research/Science 11 upvotes 2 years ago

Discouragement regarding Pyrilutamide, a drug in development for hair loss, and the potential side effects of Finasteride. People discussed anecdotal experiences with Pyrilutamide as well as suggestions to wait out Phase 3 trials before making any conclusions.

community 2 years after using finasteride

in Update 1208 upvotes 2 years ago

A user's two-year journey of using finasteride and minoxidil to treat hair loss, with other users providing advice, tips, and encouragement.

community I rather have receding temples than diffused thinning all over

in Chat 102 upvotes 3 years ago

User with diffused thinning hair prefers receding temples, as hair transplant could fix it. Finasteride and minoxidil suggested to improve hair density.

community Why I’d advise my teenage son to take propecia (opinion)

in Finasteride/Dutasteride 6 upvotes 3 years ago

The post argues for teenage use of finasteride to prevent hair loss, citing minimal side effects and personal success. Replies criticize the advice, highlighting potential developmental risks and questioning the safety of finasteride for teenagers.

community 3 months progress 7/4 - 10/1

in Finasteride/Dutasteride 69 upvotes 4 years ago

A user reported improved hair thickness after using 1mg daily of finasteride, minoxidil foam twice daily, vitamin D, and biotin shampoo, and later reduced the finasteride dose to 0.5mg. They plan to provide another update at the 6-month mark.

community The Effect of Intradermal Botox on Androgenetic Alopecia and Its Possible Mechanism (Journal of the American Academy of Dermatology (2020)

in Treatment 12 upvotes 4 years ago

Intradermal botulinum toxin (BTX) injections effectively treat androgenetic alopecia (AGA) by inhibiting TGF-β1 secretion from hair follicles. Further research and long-term follow-up are needed to confirm these findings.

community The safest way to use finasteride - my research

in Finasteride 24 upvotes 7 years ago

The post discusses microdosing finasteride to minimize side effects while treating hair loss. The user also mentions using minoxidil, biotin, and ketoconazole.