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GlossaryRetinoic Acid Receptor-Related Orphan Receptor Alpha

regulates gene expression related to circadian rhythm and metabolism

Retinoic Acid Receptor-Related Orphan Receptor Alpha (RORα) is a type of nuclear receptor that plays a crucial role in regulating various biological processes, including circadian rhythm, immune function, and metabolism. It acts by binding to specific DNA sequences and influencing the expression of certain genes, making it important for maintaining physiological balance and responding to environmental changes.

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community Androgenetic alopecia is a skin disease: DHT-mediated skin disorders

in Research/Science 65 upvotes 1 year ago

Dihydrotestosterone (DHT) impacts various skin conditions, including Androgenetic alopecia and seborrheic dermatitis, by causing overactivity in sebaceous glands. Topical medications Tacrolimus and Clobetasol can reduce these inflammatory conditions, and treatments like RU58841, Minoxidil, and Finasteride may also be beneficial.

community I’m already DOING EVERYTHING!!!

in Female 27 upvotes 3 years ago

A 26 year old female dealing with hair loss who is considering treatments such as Spiro, minoxidil and finasteride. Other potential solutions mentioned are PRP treatment, a wig, and bio-identical estrogen combined with bica.

community UPDATE: The theory that explains everything. Please help me make this big!

in Research/Science 449 upvotes 3 years ago

Hair loss theory involves 3alpha-hydroxysteroid reductase (3AHD) converting DHT to androstenol. Discussion explores potential treatments and encourages more research.

community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 3 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community Looks like a real cure to the root of baldness (DHT-induced senescence) was proven earlier this year

in Research/Science 732 upvotes 2 years ago

A study that outlines the full model for androgenic alopecia (AGA) which links DHT to cellular senescence in dermal papilla cells, and suggests black chokeberry as a source of cyanidin 3-O-arabinoside polyphenol with potential anti-oxidant properties that could reverse this process. The post encourages reaching out to experts in anti-aging and longevity to research treatments involving the polyphenol.

community My progress for 1 year minoxidil and dutasteride mesotherapy

in Progress Pictures 101 upvotes 2 years ago

A user's progress using minoxidil and dutasteride mesotherapy to treat hair loss, with advice from other users on whether or not to continue the treatment. Suggestions included trying oral treatments such as finasteride and RU58841, and considering a hair transplant for more significant results.

community 26, i was cool w shaving bald but I wanted to hold on for a little longer. Just topical min and rosemary shampoo.

in Progress Pictures 688 upvotes 1 year ago

The post and conversation are about a user's successful regrowth of hair using topical minoxidil and rosemary shampoo. Other users discuss the potential limitations of minoxidil and recommend using finasteride to maintain hair growth.

community Tretinoin aka retinoic acid, the minoxidil enhancer

in Product 8 upvotes 8 months ago

Tretinoin can make minoxidil more effective for hair loss treatment, but some users did not see improved hair density with this combination and had better results with dutasteride.

community New Product from Minoxidil Max - Topical Retinoic Acid (Tretinoin) is available now

in Minoxidil 7 upvotes 3 years ago

A new product, a retinoic acid solution (0.3%), is available to enhance minoxidil products like Rogaine and Kirkland by converting them into a tretinoin-containing solution for improved hair loss treatment. One unit of the product is enough for a year's supply.

community Just got my Dualgen-5R, the one with retinoic acid (tretinoin) but without the fin.

in Minoxidil 6 upvotes 3 years ago

The user has been using Minoxidil and finasteride with success and is now trying Dualgen-5R with retinoic acid but without finasteride, along with microneedling. They plan to share results in 5-6 months.

community Does anybody else got their hair ruined when on tretinoin?

in Chat 4 upvotes 5 months ago

The user experienced hair shedding and follicle shrinkage when using retinoic acid, despite trying different concentrations and frequencies. The hair loss persisted for six months but regrew after stopping the treatment.

community Can anyone advise me on the best brand of 2% Minox to use and mix with pyrilutamide powder

in Treatment 1 upvotes 1 year ago

Best 2% Minox brand for mixing with pyrilutamide powder and retinoic acid sought. Advice on specific treatments discussed.

community Looking to make my own 2-Deoxy-D-ribose. Any science bros can give advice?

in Research/Science 3 upvotes 3 months ago

A user is making a 2-Deoxy-D-ribose solution and asks if it can be put into an oil instead of a gel, considering adding hydrocortisone and retinoic acid. They seek advice on the best carrier oil for hair growth.

community Dandruff and Topical Solutions

in Finasteride/Dutasteride 2 upvotes 5 months ago

The user is using a topical solution with finasteride, minoxidil, and retinoic acid, which causes scalp residue and dryness. They seek advice on removing residue and keeping the scalp moisturized.

community My progress last 4 months min 10% /prp/Fotona laser

in Progress Pictures 12 upvotes 6 months ago

A user shared their 4-month progress using a serum with Minoxidil 10%, Progesterone, Azelaic acid, Retinoic acid, Latanoprost, and Hydrocortisone, along with PRP and Fotona laser treatments. They are pleased with the results and plan to continue with more PRP and laser sessions, without using Finasteride.

community Before I pull the trigger on Happy Head, are there cheaper/better alternatives for what I'm seeking?

in Product 2 upvotes 11 months ago

The conversation discusses hair loss treatments, specifically an $80/month product containing Minoxidil, Finasteride, Retinoic Acid, and Hydrocortisone with an aloe base. One reply suggests cheaper alternatives like generic oral Finasteride and liquid Minoxidil from Costco.

community switching to Kirkland Min from Online Pharmacy min?

in Minoxidil 2 upvotes 11 months ago

The user is considering switching from an expensive topical hair loss treatment containing 8% Minoxidil, 0.3% Finasteride, Retinoic Acid, and Hydrocortisone to a cheaper Kirkland brand Minoxidil. They are concerned about the effectiveness of the lower concentration and the absence of additional ingredients.

community Compounding for topical formulations?

in Treatment 1 upvotes 1 year ago

The post discusses the high cost of a topical hair loss treatment from Happy Head, which contains finasteride, minoxidil, retinoic acid, and hydrocortisone. The user is seeking cheaper alternatives, specifically asking if there are compounding pharmacies that can recreate the same or similar formulation.

community How Legit is Cortina Health for hair loss treatment.

in Treatment 6 upvotes 1 year ago

A user sought treatment for hair loss through Cortina Health, where they were prescribed a specific topical solution containing Finasteride, Minoxidil, and Retinoic Acid. They are unsure if this unique combination is better than generic products and are seeking advice on whether to trust Cortina Health.

community Update on hair, will be posting monthly! Nov 8 – Jan 14

in Progress Pictures 334 upvotes 1 year ago

A user's progress with treating their hair loss, including using finasteride, minoxidil, retinoic acid, dermapenning twice weekly and ket 2% shampoo two to three times per week. Other users offered advice such as not derma penning too often or shaving the area bald for a couple of months.

community Who is using or has used Maxogen-X ?

in Product 6 upvotes 3 years ago

The conversation is about using Maxogen-X for hair loss, which contains Minoxidil, Finasteride, Azelaic Acid, ABN Complex, Retinoic Acid, Fluocinolone, and Caffeine. The user is seeking feedback on its effectiveness.

community Minoxidilmax vs Morr-F

in Product 11 upvotes 4 years ago

The user is considering two hair loss treatments: Minoxidilmax Maxogen-x, which contains Minoxidil, Finasteride, Azelaic Acid, ABN Complex, Retinoic Acid, Fluocinolone, and Caffeine, and Morr-F, which contains only Minoxidil and Finasteride. They are asking for others' experiences with these brands.

community Dutasteride for trans men? (Topical vs oral?)

in Transgender 3 weeks ago

The conversation discusses using dutasteride, both topical and oral, for hair loss in trans men, considering potential side effects like depression and libido issues. The user is exploring options including topical solutions with minoxidil, retinoic acid, and hydrocortisone, and plans to start microneedling.

community Hair Growth Journey: 10 months

in Progress Pictures 252 upvotes 6 months ago

A 31-year-old who experienced severe hair loss during medical school tried various treatments, including topical and oral finasteride and minoxidil, but stopped due to side effects. They restarted treatment 10 months ago with a regimen including topical finasteride, minoxidil, retinoic acid, hydrocortisone, oral minoxidil, and light therapy, emphasizing the importance of consistency and skincare.

community Hey guys just came across this product,any reviews or users? It contains Minoxidil+ Finasteride+azelic acid +caffeine. TIA

in Treatment 8 upvotes 4 years ago

The conversation discusses a hair loss product containing Minoxidil, Finasteride, Azelaic Acid, and Caffeine. People are sharing their experiences and reviews of the product.

community biochemistry bros, is this hair loss solution viable?

in Finasteride/Dutasteride 2 upvotes 4 months ago

The conversation discusses using a combination of finasteride, spironolactone, minoxidil, retinol, azelaic acid, and caffeine for hair loss treatment. The user inquires about the limitations of these drugs and whether tretinoin would be more effective than retinol.

community Retinol from the ordinary for minoxidil

in Minoxidil 1 upvotes 6 months ago

Retinol or tretinoin may improve minoxidil absorption and effectiveness. The user is considering using The Ordinary's 1% retinol as tretinoin is hard to get in their country.

community What’s the consensus on tretinoin?

in Treatment 7 upvotes 5 months ago

Tretinoin may increase minoxidil absorption but could potentially worsen hair loss over time. Users discuss applying 0.5% tretinoin gel to the hairline/scalp with minoxidil.

community Switched to a once per day 7% min, 0.15% fin product. Is this a good idea? I'm a week and a half in and second guessing myself. No side effects.

in Finasteride/Dutasteride 1 upvotes 2 months ago

A 59-year-old male switched to a once-daily treatment of 7% Minoxidil, 0.15% Finasteride, and other ingredients, questioning its effectiveness compared to his previous twice-daily regimen. He has seen some hair regrowth but is unsure if the new treatment is better.

community Adding Pyri to my current treatment stack. What should I expect?

in Product 1 upvotes 3 months ago

Adding Pyri to a hair loss treatment stack. The user is inquiring about its effectiveness and side effects.