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GlossaryProstaglandin D2 Synthase

enzyme converting prostaglandin H2 to prostaglandin D2, linked to hair loss

Prostaglandin D2 Synthase (PTGDS) is an enzyme that converts prostaglandin H2 into prostaglandin D2 (PGD2), a lipid compound involved in various physiological processes, including inflammation and allergic responses. In the context of hair biology, elevated levels of PGD2 have been linked to hair loss, particularly in conditions like androgenetic alopecia.

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community Still not sure why men think diet has nothing to do with hair loss when scientific is quite the opposite [Link]

25 upvotes 6 years ago

Diet can influence hair health, but male pattern baldness (MPB) is primarily genetic. Treatments discussed include Minoxidil, finasteride, and RU58841.

community Zyrtec (Cetirizine) antihistamine for hair growth compared to Minoxidil NIH study

in Minoxidil 35 upvotes 1 year ago

The conversation discusses the potential of topical cetirizine (Zyrtec) for hair growth in comparison to minoxidil, noting cetirizine's ability to reduce prostaglandin D2, which inhibits hair growth. Users share mixed experiences with cetirizine for allergies and scalp health, and there's a mention of the risk of dementia with long-term antihistamine use.

community A science based addition to your hair loss routine

in Research/Science 23 upvotes 4 months ago

Blocking the Mitochondrial pyruvate carrier and using aldose reductase inhibitors like Indian gooseberry and berberine may help with hair growth. Magnesium can also be added to increase NADPH.

community People who apply peppermint oil, rosemary… how frequent?

in Chat 8 upvotes 1 year ago

The conversation is about the frequency of applying peppermint oil and rosemary for hair loss and what carrier oil is best to use. People are sharing their results from using these treatments.

community What else is good. Besides the big 3.

in Chat 36 upvotes 1 month ago

Key treatments for hair preservation include minoxidil, finasteride/dutasteride, and microneedling, with additional options like specific shampoos, oils, biotin, zinc, tretinoin, clascoterone, and low-level laser therapy. Maintaining a healthy lifestyle, reducing stress, and addressing nutrient deficiencies can also support hair health.

community How I started reversing Male Pattern Baldness naturally ?

in Question 6 upvotes 7 years ago

The user reversed male pattern baldness using a pro-thyroid diet, lifestyle changes, and scalp stimulation exercises, without Minoxidil or Finasteride. They reported reduced dandruff, itchiness, oiliness, and experienced hair regrowth and thickening over 15 months.

community Castor Oil - Yay or Nay?

in Product 10 upvotes 3 years ago

The conversation discusses the potential benefits of castor oil for hair thickening, with one user noting it may increase prostaglandin E2 and decrease PGD2. The original poster plans to take 1-2ml orally daily.

community Compounded topicals

in Female 6 upvotes 3 years ago

BionicBell discussed using Bimatoprost, a medication typically for eyelash growth, for hair loss and mentioned a compounding pharmacy that can mix it with other ingredients like minoxidil and finasteride. They are seeking advice on using topical finasteride for female pattern baldness and are considering a custom foam combination to maximize hair growth results.

community Autoimmune issue?

in Question 2 upvotes 6 years ago

The user experienced severe hair loss, itchy scalp, and skin issues after trying no-shampoo, and wonders if it's male pattern baldness or an immune issue. They have a history of eczema, dermatitis, and jock itch, and have tried various treatments like coconut oil, peppermint, pumpkin seed, and onion.

community Minoxidil Alternative? | Bimatoprost & Latanoprost

in Minoxidil 13 upvotes 1 year ago

Exploring alternatives to Minoxidil for hair loss, such as Bimatoprost and Latanoprost, as well as potential treatments like Finasteride and RU58841.

community All Drugs in Clinical Trials in 2023

in Research/Science 70 upvotes 1 year ago

12 companies having drugs or therapies in clinical trials during 2023, with various molecules and phases of trial; the probability that some may fail; and progress being made in the field.

community Bimatoprost research- does anyone where to buy the powder?

in Research/Science 6 upvotes 3 years ago

The post and conversation are about using bimatoprost for hair regrowth, with the user seeking a higher concentration to enhance results. The user also discusses difficulties in sourcing the powder for personal use.

community High Dose Niacin Update

in Update 7 upvotes 6 years ago

High dose niacin (1000mg daily) seems to have halted hair loss but did not regrow lost hair. The user plans to continue due to additional benefits like lower stress and higher good cholesterol.

community Interesting article links major MPB theories to western diet (and life-style)

in Research/Science 54 upvotes 3 days ago

community We Need A Solution For The Inflammatory Response related To AGA

in Research/Science 16 upvotes 2 months ago

The conversation is about finding a solution for scalp inflammation related to AGA, with the user expressing frustration that Minoxidil and Finasteride do not address inflammation. The user has researched glucocorticoids and topical NSAIDs for reducing inflammation and seeks advice from specialists.

community Finasteride + topical melatonin + rosemary oil for regrowth

in Treatment 1 upvotes 4 months ago

The user has been using finasteride for 4 months with positive results, including thicker and darker hair. They are seeking advice on maximizing hair growth without minoxidil, using a routine that includes finasteride, rosemary oil, argan oil, topical melatonin, specialized shampoos, and vitamins.

community Anyone using Peppermint oil/ similar oils and seeing growth?

in Research/Science 6 upvotes 5 months ago

Peppermint oil may be beneficial for hair growth, potentially outperforming minoxidil. Users discuss its effectiveness compared to other treatments like finasteride and RU58841.

community What all oils could be useful to augment hair growth

in Finasteride/Dutasteride 4 upvotes 5 months ago

The user uses 1mg fin every other day, a topical solution of 5% min + 0.1% fin nightly, and seeks advice on oils for hair growth. Replies suggest oils are ineffective and recommend sticking with fin and min treatments.

community Growth Stimulants that aren't Minoxidil...?

in Research/Science 7 upvotes 6 months ago

The user is exploring hair growth stimulants other than Minoxidil, mentioning Stemoxydine, various peptides, drugs like Latanoprost and Bimatoprost, and natural remedies such as Rosemary Oil and Caffeine. They express concerns about the long-term effectiveness and safety of these alternatives and seek more information on viable options for hair regrowth.

community What's your opinion on oils? Should I add those to my topical fino/mino?

in Product 6 upvotes 7 months ago

The user is considering adding castor, rosemary, and pumpkin oils to their current hair loss treatment of finasteride and minoxidil. They are unsure about the effectiveness of these oils.

community Daily aspirin is ruining your Min. gains

in Minoxidil 5 upvotes 1 year ago

Aspirin reduces the effectiveness of minoxidil for hair loss. Quercetin and 5-ASA medications also inhibit the necessary enzyme for minoxidil to work.

community dunno if it's growing anything but it's making my scalp red

in Technology 184 upvotes 1 year ago

Hair loss and potential treatments, primarily focusing on Finasteride and Minoxidil. Other solutions discussed include PRP, dermarolling, LLP, and scalp tension relief.

community My dermatologist didn't give me finasteride and instead gave me latanoprost and some cream

in Treatment 7 upvotes 3 years ago

User asked dermatologist for finasteride, received latanoprost and diprogenta cream instead. Others suggest latanoprost is expensive and not better than minoxidil, recommend trying another doctor for finasteride.

community Starting With "Strut" Topical: Dut %0.1 + Min %7.5 + Tretinoin %0.0125 + Biotin (and more)

in Treatment 9 upvotes 3 years ago

The user started a hair loss treatment with a topical solution containing 0.1% Dutasteride, 7.5% Minoxidil, 0.0125% Tretinoin, and Biotin, along with a multivitamin, Ashwagandha, CBD oil, Retinol, and Caffeine Solution. They experienced some shedding and scalp irritation, leading to a reduction in the use of the caffeine solution.

community Future hope ? What do you guys predict ? clascoterone, pyrilutamide, gt20029 etc.

in Treatment 15 upvotes 3 years ago

User tried oral finasteride, topical finasteride, topical dutasteride, and RU58841 but experienced side effects. They discuss upcoming treatments like clascoterone, pyrilutamide, gt20029, and KY19382 as potential options.

community The Big Fat Layer / Remedies: Cetirizine

in Treatment 12 upvotes 3 years ago

Treating hair loss with various remedies, such as Cetirizine and the Big3 complex (minoxidil, finasteride, and RU58841), which have properties like adipogenic, anti-fibrotic and anti-inflammatory. References to research studies are also included.

community Does microneedling regrow hair on dormant bald regions which have been bald for many years?

in Microneedling 6 upvotes 4 years ago

Microneedling may help regrow hair in dormant bald regions by stimulating stem cell transfer. Users discuss its effectiveness and how collagen might aid in the process.

community My Theory Regarding a Cause and Cure for Androgenetic Alopecia

in Treatment 98 upvotes 4 years ago

Hair loss theory suggests imbalance between Vitamin D Receptor (VDR) and Androgen Receptor (AR) activation. Proposed treatment includes upregulating VDR, downregulating AR, and improving mitochondrial health.

community My opinions on hair treatment right now and in future

in Treatment 22 upvotes 4 years ago

Finasteride, minoxidil, dermarolling, and topical antiandrogens are effective for hair regrowth. Future treatments may include CB0301 and hair cloning.

community 8 months on Fin and Min, with no change. Give up or switch to dut and add micro needling?

in Progress Pictures 18 upvotes 5 months ago

A user has seen no progress after 8 months on finasteride and minoxidil and is considering switching to dutasteride and adding microneedling or quitting and getting a hair system. Another user suggests adding microneedling and dutasteride and buzzing the hair down.