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GlossaryPremature Senescence

early cellular aging causing permanent growth arrest

Premature senescence refers to the early onset of cellular aging, where cells stop dividing and enter a state of permanent growth arrest earlier than expected. This can be triggered by various stress factors such as DNA damage, oxidative stress, or chronic inflammation, and is often associated with conditions like alopecia, where hair follicles may stop functioning properly, leading to hair loss.

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community Looks like a real cure to the root of baldness (DHT-induced senescence) was proven earlier this year

in Research/Science 743 upvotes 2 years ago

A study that outlines the full model for androgenic alopecia (AGA) which links DHT to cellular senescence in dermal papilla cells, and suggests black chokeberry as a source of cyanidin 3-O-arabinoside polyphenol with potential anti-oxidant properties that could reverse this process. The post encourages reaching out to experts in anti-aging and longevity to research treatments involving the polyphenol.

community 18 months. Dutasteride, RU58841, Minoxidil, Microneedling, Nizoral, T/GEL

in Progress Pictures 168 upvotes 4 years ago

A 28 year old man's 18-month journey to treat his hair loss with Dutasteride, RU58841, Minoxidil, Microneedling, Nizoral and T/GEL. He experienced some side effects along the way, including translucent semen and scalp less oily.

community Countering oral minoxidil side effects by taking collagen supplements?

in Minoxidil 16 upvotes 6 months ago

Oral minoxidil may deplete collagen, potentially causing skin aging. Users discuss whether taking collagen supplements can counteract this effect.

community Could low blood flow to the head cause an increased rate of thinning?

in Chat 27 upvotes 3 years ago

The user started using finasteride, minoxidil, and biotin for male pattern baldness (MPB) and is experiencing rapid thinning. They are questioning if low blood flow to the head could be contributing to their hair loss.

community The Real Cause Of Androgenetic Alopecia

in Research/Science 667 upvotes 2 months ago

Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.

community Has any premature balding guys actually saved and maintained their hair?

in Chat 20 upvotes 2 weeks ago

A user discusses their struggle with aggressive hair loss starting at a young age and their use of various treatments, including topical finasteride, minoxidil, dutasteride, and RU58841, without significant success. Other users share their experiences and suggest trying oral finasteride or dutasteride, topical spironolactone, and maintaining a vitamin regimen, while noting potential side effects like gynecomastia.

community Any other females with no family history of hair loss?

in Female 6 upvotes 6 years ago

A female experiencing premature full-blown male pattern baldness with no family history of hair loss, and other users sharing their experiences.

community Tretinoin potentially can make hair loss worse ?

in Research/Science 6 upvotes 2 years ago

Tretinoin may worsen hair loss by inducing premature hair follicle regression. It can be used with minoxidil to increase absorption but should not be used alone.

community Does Vitamin C serum negate the the collagen reduction that Minoxidil causes?

in Minoxidil 7 upvotes 7 years ago

Minoxidil can inhibit collagen production, potentially causing premature aging. The user is inquiring if Vitamin C serum or derma rolling can counteract this effect.

community SAFFLOWER OIL good alternative for Minoxidil?

in Treatment 1 upvotes 4 years ago

Safflower oil is suggested as an alternative to minoxidil for hair growth, with benefits including scalp conditioning and hair strength enhancement. Studies indicate it may also reverse scalp dermatitis, alopecia, and prevent premature grayness.

community Why is it barely impossible to find balding South Korean men

in Research/Science 246 upvotes 1 year ago

The post discusses the rarity of baldness among South Korean men. Users suggest this could be due to early treatment, high beauty standards, accessibility of healthcare, and genetics. Treatments like finasteride and dutasteride are commonly used, and hair transplants are also popular.

community How is it that my new hair strands are all black while before thinning they had a lot of white as well?

in Treatment 3 upvotes 1 year ago

A user noticed that after using finasteride and a regrowth spray, their new hair strands are all black, unlike their previously white hair. They are puzzled by this change and seek an explanation.

community If you feel deep about your hair loss, read this, this is my experience & things I want to discuss!

in Research/Science 6 upvotes 3 years ago

The user experienced hair loss from age 16 to 24 and tried various treatments. Effective treatments included Finasteride, Minoxidil, and hair transplants, while thickening shampoos, biotin, laser hair therapy, and excessive exercise were ineffective.

community DHT/Testosterone levels in scalp Fin VS Dut.

in Finasteride/Dutasteride 60 upvotes 5 months ago

Dutasteride raises scalp testosterone by 99%, which may not be ideal for those sensitive to all androgens. Some argue finasteride's balancing act might be better, while others believe dutasteride is superior for hair regrowth.

community Spironolactone topically with a try ?!

in Research/Science 1 upvotes 10 months ago

A 30-year-old male is considering using dutasteride and fluridil for hair loss maintenance and is curious about the effectiveness of topical spironolactone, as he cannot take finasteride. He is also planning a hair transplant.

community I was scared of Fin. I now love it

in Update 19 upvotes 1 year ago

A 25-year-old male switched from multiple topicals to finasteride and minoxidil for hair loss, experiencing maintenance and increased confidence despite minor side effects. He now styles his hair freely and appreciates the positive impact of finasteride.

community If finasteride and dutasteride are supposed to maintain the hair that you have, then why do you go through a shedding phase?

in Finasteride/Dutasteride 18 upvotes 1 year ago

Hair loss treatments Finasteride and Dutasteride may cause shedding, but it's a good sign as miniaturized hairs are replaced by thicker ones. Shortness of breath may be experienced from Dutasteride or oral Minoxidil.

community Advice on Eucapil (fluridil) after minoxidil foam

in Treatment 2 upvotes 1 year ago

User asks if applying Eucapil (fluridil) after minoxidil foam is possible. Seeks advice from others with experience.

community It is said that minoxidil decreases collagen production. Any anecdotes here that have quit minoxidil and got better skin as a result?

in Minoxidil 9 upvotes 1 year ago

Minoxidil is discussed for its potential to decrease collagen production, with users sharing experiences about skin improvement after stopping its use. Some mention using it on their face for beard growth.

community How all hormones affect our hair follicles. Not just DHT. Take a look at this paper. Prolactin, melatonin, cortisol, progesterone, testosterone and more

in Research/Science 126 upvotes 2 years ago

The conversation discusses various factors affecting hair loss, not just DHT, and mentions treatments like Minoxidil, finasteride, and melatonin. Some users report personal experiences with these treatments and hormone tests, while others speculate on the role of hormones like prolactin and cortisol in hair loss.

community Fighting Hair loss AND Grey Hair

in Treatment 18 upvotes 2 years ago

The user is treating hair loss with topical Minoxidil, Finasteride, RU58841, microneedling, and Ketoconazole. For grey hair, they use L-Cysteine, L-Methionine, and PABA, and have noticed some re-pigmentation.

community If ancient hunter gatherer women had just selected for men with hair we wouldn't be in this mess

in Satire 128 upvotes 1 day ago

Hair loss is humorously blamed on ancient selection preferences, with discussions on genetics and societal norms. Treatments like finasteride are mentioned as modern solutions.

community Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens.

in Research/Science 1 upvotes 2 weeks ago

A method for treating androgenic alopecia using minoxidil, antiandrogens, exercise, and cold exposure to promote hair growth. Environmental factors and lifestyle changes, like diet and exercise, can improve treatment effectiveness.

community Genetics are so weird and unpredictable

in Minoxidil 118 upvotes 1 month ago

The user experienced male pattern baldness starting at 18, tried finasteride with no success, and switched to dutasteride, which halted hair loss. Minoxidil had no effect for them, while their brother, who didn't use AR inhibitors, maintained a juvenile hairline and successfully grew a beard with minoxidil, highlighting the unpredictable nature of genetics in hair loss and treatment response.

community No longer need a hat to leave the house. Praise Jesus. 12 months progress. 24 years old.

in Progress Pictures 1219 upvotes 5 months ago

A 24-year-old shared his 12-month hair loss progress, using 1mg oral finasteride daily, Minoxidil spray twice daily, weekly derma stamping, daily Biotin, Saw Palmetto Shampoo, and occasional Ketoconazole shampoo. He experienced minimal side effects and significant hair density improvement, no longer needing a hat.

community Min + fin oral for eight months

in Progress Pictures 342 upvotes 7 months ago

The user shared progress pictures after using Minoxidil and oral Finasteride for eight months to treat hair loss. They experienced significant hair regrowth, and the discussion includes various opinions on the necessity and effectiveness of these treatments.

community Can a folate deficiency make androgenetic alopecia worse?

in Treatment 1 upvotes 11 months ago

The user is treating androgenetic alopecia with finasteride and discovered a folic acid deficiency. They are asking if curing the deficiency can worsen or improve their hair condition.

community Topical Prednisolone as hair loss treatment?

in Treatment 1 upvotes 2 years ago

A user is concerned about using Alpicort, which contains Prednisolone and Salicylic Acid, for male pattern baldness. They are unsure if it will help or worsen their condition and are seeking advice.

community Vitamin D advice I received after seeing my blood work.

in Research/Science 88 upvotes 3 years ago

The conversation discusses the importance of taking vitamin D with food for better absorption and its potential role in hair loss. Some users also suggest taking vitamin D with K2, getting sunlight, and using finasteride for hair loss treatment.

community [AMA] 5-Month Progress Report: Dutasteride and Oral Minoxidil Results.

in Minoxidil 73 upvotes 3 years ago

Naepo's 5-month progress report detailing their journey of treating male pattern baldness with dutasteride and oral minoxidil, which has already resulted in an encouraging improvement in hair density. Others have responded with appreciation for the thorough report and asked further questions about Naepo's educational background.