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GlossaryNext-Generation Sequencing

modern DNA sequencing technology that processes millions of fragments simultaneously

Next-Generation Sequencing (NGS) is a modern DNA sequencing technology that allows for the rapid sequencing of large stretches of DNA or entire genomes. Unlike traditional methods, NGS can process millions of DNA fragments simultaneously, making it a powerful tool for genetic research, including studying genetic causes of diseases like alopecia.

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community I believe CRISPR-on & CRISPR-off is an ultimate CURE for baldness, unlike Hair Cloning or hair loss treatments.

in Research/Science 22 upvotes 3 years ago

The conversation discusses CRISPR-on & CRISPR-off as a potential cure for baldness, contrasting it with hair cloning and other treatments like Minoxidil, finasteride, and RU58841. It also mentions the potential of mRNA for gene expression control and the prioritization of gene editing for severe genetic conditions.

community Why is dht bad for scalp hair but good for hair on the rest of body?

in Satire 109 upvotes 1 year ago

The conversation discusses why DHT (dihydrotestosterone) negatively affects scalp hair but promotes growth elsewhere on the body. Various opinions include genetic predispositions, differences in hair follicle reactions to DHT, and the potential role of Omega-3 in reducing inflammation and promoting hair health.

community Pyrilutamide binding affinity is similar to RU

in Research/Science 16 upvotes 1 year ago

Comparing the effectiveness of RU58841, Pyrilutamide and CB-03-01 as treatments for hair loss, with people discussing different aspects such as binding affinity, time of inhibition, safety data and cost.

community A new meta-analysis of 23 studies has confirmed that 5 milligrams a day of oral dutasteride had the highest probability of reducing male hair loss, followed by 5 milligrams a day of oral finasteride, followed by 5 milligrams of oral minoxidil, followed by 1 milligram a day of oral finasteride

in Research/Science 82 upvotes 2 years ago

Oral dutasteride (0.5mg) is most effective for male hair loss, followed by oral finasteride (5mg), oral minoxidil (5mg), and oral finasteride (1mg). Different treatments have benefits and side effects, and results don't apply to women's hair loss.

community Binding affinity of pyrilutamide!

in Update 168 upvotes 2 years ago

Pyrilutamide, a nonsteroidal antiandrogen drug under development for the potential treatment of androgenic alopecia. The conversation discusses its binding affinity to the androgen receptor and the timeline for possible availability after trials are completed in the United States and China.

community Thin spots over time even with Finasteride

in Progress Pictures 132 upvotes 7 months ago

A user shared their experience with Finasteride for hair loss, noting improvement but still some thinning. They plan to get a hair transplant to address remaining thin spots and strengthen their hairline.

community When are we getting a cure to hair loss?

in Chat 1 year ago

Potential treatments for hair loss, including Minoxidil, finasteride, RU58841 and various upcoming pharmaceuticals, gene editing and cloning. It is suggested that a cure, if found, would be highly profitable due to the large number of people affected by hair loss globally.

community New drug for hair loss announced by Amplifica

in Research/Science 161 upvotes 1 year ago

Amplifica starting clinical trials for new hair loss drug. SCUBE3 protein discovered, stimulates hair growth, could be alternative to Minoxidil and Finasteride.

community Cigarette smokers had increased serum levels of DHT 14% higher than non smokers.

in Chat 82 upvotes 1 year ago

The effects of smoking cigarettes on DHT levels and its potential effect on hair loss, with some people sharing experiences in relation to their own hair loss. Various treatments for reducing or reversing hair loss were discussed, such as quitting smoking, minoxidil, finasteride and RU58841.

community My barber is seriously making me lose hope

in Minoxidil 2 years ago

This conversation is about a user struggling with hair loss who has been told by their barber that minoxidil does not work and the only solution is to accept it. Other users have encouraged them to continue using finasteride and minoxidil, as well as look for another barber, since these treatments are scientifically proven to be effective in combating hair loss.

community Why balding gets worse in every generation?

in Chat 81 upvotes 5 months ago

Balding seems to worsen with each generation, possibly due to stress, diet, and environmental factors. The user started treatments like Minoxidil and finasteride.

community Fucking hell (Easter)

in Chat 459 upvotes 3 years ago

User hears aunt's comment on hair loss during Easter gathering. Others discuss handling rude comments and share experiences with hair loss treatments like Minoxidil and Finasteride.

community Why anecdotal evidence is so valued around here?

in Chat 18 upvotes 7 months ago

The conversation discusses why personal stories about hair loss treatments like Minoxidil and finasteride are often taken more seriously than scientific evidence in certain forums. People tend to believe what they want and use others' experiences to support their own views on treatment effectiveness and side effects.

community What hurts the most is that only minority of us are balding

in Chat 252 upvotes 1 year ago

The conversation discusses the emotional impact of early hair loss in men, with many feeling isolated and self-conscious. Some users also mention the lack of awareness about potential treatments like Minoxidil and Finasteride.

community Compared to the hair of your father at your age how is your hair doing?

in Finasteride/Dutasteride 29 upvotes 1 year ago

How people's hair is compared to their fathers' at the same age, with some users noting that they have inherited different genes from either parent and are using treatments such as finasteride for hair loss.

community This is the best time in human history to be fighting hair loss

in Treatment 193 upvotes 2 years ago

This conversation discusses the advancements in treatments for hair loss, including finasteride, dutasteride, minoxidil and new promising treatments such as pyrilutamide and verteporfin. Other treatments discussed were taking minoxidil orally, tretinoin to turn non-responders into responders and microneedling to further boost growth.

community A meta analysis of 18 popular hair loss treatments. An 2022 guide on efficacy. From finasteride and minoxidil to caffeine shampoo, saw palmetto and biotin. 96 Scientific References included.

in Research/Science 101 upvotes 2 years ago

Most hair loss treatments are ineffective; only finasteride, dutasteride, and minoxidil show effectiveness.

community New and Interesting HairLoss Studies/Papers/Reviews

in Treatment 44 upvotes 4 years ago

Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

community For anyone having trouble with the pain of dermarolling

in Treatment 117 upvotes 5 years ago

Treating hair loss with dermarolling and other treatments such as Minoxidil, Finasteride, and RU58841.

community 27m gone bald, hair in 2018 to no hair 2024 considering HT

in Shaved/buzzed 172 upvotes 4 months ago

A 27-year-old considering a hair transplant after going bald from 2018 to 2024. Recommendations include using finasteride and minoxidil before the transplant, with mixed opinions on their long-term use and side effects.

community After 11 Years On Finasteride, Unfortunately, Hair Is Starting To Thin Again. Does Hair Simply Get More Sensitive To DHT As You Age?

in Finasteride/Dutasteride 95 upvotes 6 months ago

After 11 years on Finasteride, a user's hair is thinning again, suggesting hair may become more sensitive to DHT with age. They plan to introduce Dutasteride once a week, as they cannot tolerate Minoxidil.

community Yes, most models are absolutely on finasteride

in Finasteride/Dutasteride 1104 upvotes 9 months ago

The conversation discusses how many male models and celebrities likely use finasteride to prevent hair loss, with some expressing surprise that it's not just good genetics keeping their hair intact. Specific treatments mentioned include finasteride and, in one query, minoxidil.

community Why isn’t anyone talking about this?

in Research/Science 31 upvotes 9 months ago

Hair cloning is being developed by companies like Kangstem Biotech and Stemson, with potential availability in a few years. Initial costs are expected to be high, but prices may decrease over time.

community how does my progress look 18M 3 months on fin 1mg daily

in Progress Pictures 277 upvotes 1 year ago

An 18-year-old male's successful hair regrowth after three months of using finasteride 1mg daily. He reported no side effects and other users expressed admiration and curiosity about his results.

community Why is it barely impossible to find balding South Korean men

in Research/Science 244 upvotes 1 year ago

The post discusses the rarity of baldness among South Korean men. Users suggest this could be due to early treatment, high beauty standards, accessibility of healthcare, and genetics. Treatments like finasteride and dutasteride are commonly used, and hair transplants are also popular.

community Dude had better hair at over 100 years of age than many of us at 20

in Satire 1450 upvotes 1 year ago

Hair loss discussion mentions Native Americans' resistance to male pattern baldness and lack of facial hair. Users discuss genetics, sun exposure, and potential treatments like minoxidil and finasteride.

community cosmeRNA finally now it's pyrilutamide turn

in Chat 49 upvotes 1 year ago

Hair loss treatments discussed include cosmeRNA, minoxidil, finasteride, RU58841, and pyrilutamide. Users debate effectiveness, side effects, and upcoming treatments, with some expressing skepticism and others optimism.

community Cmon Pyrilutamide and CosmeRNA 😭

in Chat 37 upvotes 1 year ago

Users discuss waiting for new hair loss treatments and share struggles with side effects from current options like Minoxidil and Finasteride. They express hope for Pyrilutamide and CosmeRNA to provide better solutions.

community Looks like a real cure to the root of baldness (DHT-induced senescence) was proven earlier this year

in Research/Science 732 upvotes 2 years ago

A study that outlines the full model for androgenic alopecia (AGA) which links DHT to cellular senescence in dermal papilla cells, and suggests black chokeberry as a source of cyanidin 3-O-arabinoside polyphenol with potential anti-oxidant properties that could reverse this process. The post encourages reaching out to experts in anti-aging and longevity to research treatments involving the polyphenol.

community 3α-Hydroxysteroid dehydrogenase community driven study, not anytime soon guys.

in Research/Science 105 upvotes 3 years ago

High cost of studying 3α-Hydroxysteroid dehydrogenase in hair loss led to suggestions of crowdfunding for research. Users discussed using Procyanidin B2/melatonin topical treatment and tracking funds with blockchain.