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GlossaryMatrix Metalloproteinase-1

enzyme that breaks down collagen in connective tissues

Matrix Metalloproteinase-1 (MMP-1), also known as interstitial collagenase, is an enzyme that breaks down collagen, a key structural protein in the skin and other connective tissues. This process is crucial for normal tissue remodeling and repair, but excessive MMP-1 activity can contribute to conditions like skin aging and certain diseases by degrading too much collagen.

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community This serum outperformed Minoxidil in a recent study. Please debunk

23 upvotes 4 years ago

A topical solution called "Multi-Peptide Serum for Hair Density" by The Ordinary Company, which contains several ingredients that are used in alternatives to Minoxidil and was found to have better results than 5% Minoxidil in a study. People who have tried it shared their experiences with the serum as well.

community Best Treatment In The Pipeline?

in Chat 15 upvotes 1 month ago

New treatments for AGA are emerging, including pyrilutumide, gt0029, scube3, kx-826, and pp405. Verteporfin is mentioned as a promising option.

community microneedle, any long term users damage?

in Microneedling 33 upvotes 2 months ago

Microneedling is effective for hair growth, especially when combined with finasteride and minoxidil, but concerns exist about potential long-term skin damage. Users report increased collagen and elastin deposition, but the long-term effects on the scalp remain uncertain.

community Has anyone else seen this encouraging verteporfin case study?

in Progress Pictures 34 upvotes 8 months ago

The conversation discusses the potential use of verteporfin for hair loss treatment, with one user mentioning their surgeon's interest in trying it and another noting its research status and clinical use as a YAP inhibitor. Some users debate the market size, availability of generics, and the optimism in the hair loss community regarding new treatments.

community Tropoelastin injections + verteporfin?

in Research/Science 12 upvotes 1 year ago

The use of tropoelastin injections and verteporfin for hair transplant recipients to help regrow donor area hairs, as well as research done on tropoelastin injections restoring elastin in scarred heart tissue and skin. There are discussions about why it is taking so long to get cosmetic mass produced tropoelastin injectables on the market.

community I am RESTLESS and not STRESSLESS due to my issues of TRESSLESS :(

in Female 13 upvotes 3 years ago

A female user is experiencing severe hair loss, especially at the crown and front, with broken and dull hair despite using Moroccan oil, shea moisture shampoo, and coconut oil. She seeks recommendations for a clinic or doctor as previous doctors attributed the issue to stress but offered no solutions.

community Sandalore: a scientific homemade approch

20 upvotes 5 years ago

The post discusses using Sandalore as a potential hair loss treatment, emphasizing precise measurements and safe handling. The user compares Sandalore's effects to Minoxidil and mentions preparing a solution with ethanol and DMSO.

community Do you think these will work? Some of these companies claim to have a cure by 2019-2025

7 upvotes 6 years ago

The conversation discusses the potential effectiveness of hair loss treatments, with some companies claiming to have a cure by 2019-2025. Specific treatments mentioned include Minoxidil, finasteride, and RU58841.

community What if I told you you could have it all back? May 2023 to now

in Progress Pictures 154 upvotes 8 months ago

The conversation is about a user's 7-month hair regrowth progress using finasteride/minoxidil gel, minoxidil foam, ketoconazole shampoo, thickening shampoo and conditioner, biotin supplements, and plans to start using a dermaroller. Replies suggest a new haircut and commend the user's progress.

community Mark Normand talks about finasteride experience

in Finasteride/Dutasteride 821 upvotes 1 year ago

The conversation is about hair loss and the use of finasteride as a treatment. Some users share their positive experiences with finasteride, while others mention side effects they have experienced.

community 4.5 Months on oral dut 0.5mg, oral min 5mg, topical RU 80mg, weekly microneedling at 1.5mm

in Progress Pictures 82 upvotes 1 year ago

User tried oral dut 0.5mg, oral min 5mg, topical RU 80mg, and weekly microneedling at 1.5mm for hair loss. Others commented on the significant improvement and potential for future hair transplant.

community Actor Patrick Stewart, 82, has a receding hairline. I thought it was pretty cool to see an older actor being successful, despite dealing with hair loss. He’s been knighted by Queen Elizabeth II and just voted “Sexiest Man Alive” by Glamour for the second time

in Satire 1 year ago

Actor Patrick Stewart's success despite having a receding hairline, how hair loss may not be as crippling as it is perceived to be, and how different people are attracted to different physical features.

community “Guys, am I norwood 3? Should I take fin?”

in Satire 446 upvotes 1 year ago

Hair loss, and treatments such as finasteride and oral minoxidil being discussed. Some people shared stories of their personal experiences while others gave humorous replies.

community Is it time for my 3-Year Old Nephew to get on Fin & Min? 😓

in Satire 517 upvotes 1 year ago

Hair loss in a 3-year-old, with various treatments discussed such as minoxidil, finasteride, dutasteride, RU58841 and biotin supplementation. Some people suggested shaving the head and growing a beard or getting a partial hairpiece instead of attempting to treat it.

community Why Is Only Tressless Talking About Verteporfin? Healing Wounds With Zero Scarring Has Gargantuan Implications For All of Medicine. So What Gives?

in Research/Science 20 upvotes 1 year ago

The potential of verteporfin to heal wounds without scarring; however, despite its promising preclinical trials and coverage from a major media outlet, there is still no official clinical trial result and the drug has only garnered attention from hair loss communities.

community 2.5 yrs progress: Min + dermaroll + niz

in Progress Pictures 76 upvotes 1 year ago

A user's 2.5 year hair loss progress with Minoxidil, dermarolling, and Nizoral treatments, as well as taking biotin and a multivitamin supplement, with the intention of trying DIY topical finasteride in the future.

community For those of you who are getting facial skin side effects (aging, dark circles) from minoxidil, try this, it helped me.

in Minoxidil 13 upvotes 3 years ago

The conversation provides tips to reduce facial skin side effects from Minoxidil, such as changing pillowcases, sleeping on the back, careful application, hydration, and taking breaks. One reply suggests that alcohol in Minoxidil formulations, not Minoxidil itself, may cause skin aging.

community Dental technician is convinced that he has found the cause of pattern hair loss

in Research/Science 315 upvotes 1 week ago

A dental technician claims malocclusion causes pattern hair loss due to poor scalp circulation. Users debate this, noting treatments like finasteride, minoxidil, and microneedling focus on DHT and blood flow.

community Why is it that low testosterone causes hair loss as well? How can I be balding?

in Chat 158 upvotes 4 months ago

The conversation discusses the confusion over low testosterone potentially causing hair loss, with users sharing personal experiences and knowledge about hair loss treatments like Finasteride. Some users suggest that hair follicle sensitivity to DHT, not testosterone levels, is the key factor in balding, and others discuss the side effects of hair loss medications.

community Killing the Norwood Reaper, a Journey

in Progress Pictures 374 upvotes 5 months ago

The user is treating hair loss with a regimen including Dutasteride, oral and topical Minoxidil, microneedling, and various supplements for overall health. They are considering adding tretinoin, stemoxydine/RU, DIM, Boron, and Fadogia Agretis to their routine.

community New Treatments, and a Huge Group Buy with Lots of Research

in Research/Science 111 upvotes 11 months ago

A user is organizing a group buy for various compounds aimed at reversing hair loss and gray hair, and improving brain health and fat loss. The user has developed a treatment plan based on extensive research and is inviting others to participate, with the option to choose only the compounds they need.

community 2 months and half progress. Just take the f*cking pill. (Completely wet hair)

in Progress Pictures 315 upvotes 1 year ago

User shares 2.5-month progress with hair loss pill, others discuss their experiences and results. Some mention using Minoxidil, Finasteride, and microneedling for hair regrowth.

community I will have it cured by morning

in Research/Science 370 upvotes 1 year ago

Researching the cause of hair loss and treating it by preventing DHT in the scalp with medication such as finasteride or dutasteride, estrogen, minoxidil, dermarolling, and possible topical antiandrogens.

community Boys, ALWAYS do your due diligence before going the hair transplant route!

in Transplants 643 upvotes 1 year ago

A user's experiences with hair loss treatments, including finasteride and hair transplants, in relation to another person who has been publicly vocal about their own hair loss struggles. People have shared opinions on this other person's treatment choices and the results of their hair transplant.

community Oral minoxidil is not good for your health, let’s use research chemicals bought from AliExpress

in Satire 551 upvotes 1 year ago

. This conversation discussed the efficacy of Minoxidil and Finasteride as treatments for hair loss, with a focus on the potential side effects of taking Oral Minoxidil. Some users shared their experiences with both treatments and there was debate over whether they were safe or not.

community 8 mos: oral (Du, Min), topical (Min, Ru, Ketoconazole), microneedling. NW7 for 7 years

in Progress Pictures 945 upvotes 1 year ago

A user's success in hair regrowth after taking oral and topical medications, such as minoxidil and dutasteride, and using microneedling. Other users shared their experiences and advice with treatments used to reverse hair loss.

community A meta analysis of 18 popular hair loss treatments. An 2022 guide on efficacy. From finasteride and minoxidil to caffeine shampoo, saw palmetto and biotin. 96 Scientific References included.

in Research/Science 103 upvotes 2 years ago

Most hair loss treatments are ineffective; only finasteride, dutasteride, and minoxidil show effectiveness.

community Remember to take care of your hair condition.

in Chat 107 upvotes 3 years ago

Taking care of hair condition through the use of shampoo, conditioner, oils and scalp scrubs, as well as advice on using Nizoral and Naturebox Olive Shampoo. Replies also included discussion about whether a bad shampoo could be causing hair loss.

community Balding, short, small penis. What is the point of living…

in Treatment 405 upvotes 3 years ago

A 24 year old male struggling with the physical and mental effects of balding, being short, and having a micropenis. Suggested treatments include taking medications such as finasteride and minoxidil, lifting weights, and trying not to compare himself to others.

community Age-linked hair loss caused by disappearing collagen, researchers say

57 upvotes 4 years ago

Age-linked hair loss is linked to disappearing collagen. Treatments discussed include minoxidil, finasteride, RU58841, tretinoin, microneedling, and collagen supplements.