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GlossaryLower Urinary Tract Symptoms

refer to issues with urination involving the bladder and urethra

Lower Urinary Tract Symptoms (LUTS) refer to a range of symptoms related to problems with the bladder and urethra. These can include difficulty in urination, frequent urination, urgency, and incomplete bladder emptying. LUTS can be caused by various conditions such as benign prostatic hyperplasia (BPH) in men, urinary tract infections (UTIs), or overactive bladder.

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community Massive study on finasteride side effects released

in Finasteride/Dutasteride 83 upvotes 2 years ago

The release of a study on 5a-reductase inhibitors (finasteride and dutasteride) which showed an increased risk of depression, dementia, decreased libido, and reduced semen load as potential side effects; discussion around other forms of hair loss treatments such as topical minoxidil, RU58841, or opting to accept baldness; and advice to consider professional help for deeper issues related to hair loss.

community A meta analysis of 18 popular hair loss treatments. An 2022 guide on efficacy. From finasteride and minoxidil to caffeine shampoo, saw palmetto and biotin. 96 Scientific References included.

in Research/Science 103 upvotes 2 years ago

Most hair loss treatments are ineffective; only finasteride, dutasteride, and minoxidil show effectiveness.

community Topical Anti-Androgen users. What are y’all using currently? And what do you believe has the best chance of being approved? Or best results?

in Technology 13 upvotes 2 months ago

RU58841 is considered effective by some users, but finasteride and minoxidil are commonly used with varying dosages to manage side effects. Users report different experiences with treatments like pyrilutamide, fluridil, and RU58841, with some seeing results and others not.

community Here are the results from my journey! I used saw palmetto tablets instead of Finasteride(I was afraid of using it), 5% Minoxidil spray and Derma Pen once a week 1.5mm.

in Progress Pictures 306 upvotes 1 year ago

The user shared their positive hair regrowth experience using saw palmetto tablets, 5% minoxidil spray, and a Derma Pen. The conversation debates the effectiveness of saw palmetto versus finasteride, with some advocating for natural treatments and others emphasizing the proven results of finasteride and minoxidil, often in combination with microneedling.

community 22M results after 1 year of fin 1.25mg/day

in Progress Pictures 794 upvotes 1 year ago

A user's results after using finasteride (1.25mg/day) for one year, which included improvements to their hair and skin as well as some side effects such as decreased libido and watery semen. They also mentioned they stopped taking creatine around the same time.

community Scientific Review: Saw Palmetto is not effective for treating hair loss and does not inhibit DHT to the extend that most people think. Anti-Hair loss claims are invalid.

in Research/Science 35 upvotes 2 years ago

Saw Palmetto is not effective for hair loss treatment and is not a recommended alternative to finasteride due to its inability to significantly inhibit DHT.

community Debunking the "Adverse metabolic consequences of dutasteride"

in Research/Science 40 upvotes 3 years ago

Dutasteride is more effective than finasteride, has neuroprotective benefits, and may prevent acne. Despite initial concerns about metabolic effects, further research suggests it is safe for most users, especially if not hypogonadal.

community I Get Side-Effects from Anti-Androgens

in Finasteride/Dutasteride 9 upvotes 4 years ago

Someone looking for solutions to their hair loss, who has tried and failed to tolerate anti-androgen treatments such as finasteride, CB-03-01, RU58841, and Eucapil. The user is seeking advice and understanding of their extreme sensitivity to these treatments.

community 📈 Solving for very low dose topical finasteride titration intervals

in Research/Science 30 upvotes 4 months ago

The conversation discusses using very low dose topical finasteride to achieve specific serum DHT reduction percentages. It concludes that finasteride dosage increases linearly between 5-30% DHT reduction but requires exponential increases for reductions up to 70%.

community Found this research paper showing how males with pattern hair loss show lower levels of iron and/ or Ferritin. Might be helpful to those here asking about nutrition.

in Research 17 upvotes 4 years ago

Lower levels of Ferritin and iron are linked to male pattern baldness. Checking these levels could provide clinical benefits.

community Does lowering serum prolactin lower prolactin in the scalp?

in Research/Science 13 upvotes 10 months ago

The conversation discusses whether not masturbating (semen retention) affects hair loss, with opinions varying but generally dismissing the idea. Some participants mention using hair loss treatments like Minoxidil, Finasteride, and RU58841, but the effectiveness and relation to prolactin levels in the scalp are debated.

community By how much does alfatradiol lower DHT levels?

in Ketoconazole 7 upvotes 2 years ago

Hair loss discussion includes Minoxidil, Finasteride, and RU58841 treatments. User asks how much alfatradiol lowers DHT levels.

community How do you guys deal with lower libido?

in Finasteride/Dutasteride 22 upvotes 3 years ago

A user discusses dealing with lower libido caused by finasteride, considering using ED meds but unsure due to age. Replies suggest natural libido fluctuations, holistic approaches, and managing anxiety.

community Everyone is ignoring that plasma finasteride levels are 100x lower with topical compared to oral.

in Research/Science 133 upvotes 5 months ago

Topical finasteride results in plasma levels 100 times lower than oral finasteride, potentially reducing systemic side effects. Users report similar efficacy with fewer side effects, suggesting a preference for topical application.

community Is anyone taking both boron and p5p to lower SHBG and Prolactin respectively? What are you experience on this?

in Update 6 upvotes 1 year ago

The user is applying topical finasteride with stemoxydine for hair loss and has noticed hair thickening but no regrowth after two months. They also report high SHBG and prolactin levels and a lack of morning erections, even on low doses of medication.

community 6-months on Hims topical minoxidal and finasteride combination, and microneedling once every week or two. The before pic was taken with the front iphone camera so is lower resolution which makes a comparison hard, but perhaps seeing some minor gains in individual hairs thickening.

in Progress Pictures 2 years ago

Using a combination of topical minoxidil and finasteride, plus microneedling, to treat hair loss; the progress made by the original poster over 6 months; the potential for further results with longer use; and the possibility of seeking alternatives such as a hair transplant or system.

community New topical Dutasteride from Moogene will have 20 times better scalp absorption than oral Dutasteride. And much lower system absorption.

in Finasteride/Dutasteride 178 upvotes 2 years ago

A new topical Dutasteride with 20 times better scalp absorption being developed and tested for release in 2023; use of existing drugs, such as Minoxidil and finasteride; and mesotherapy as an alternative hair loss treatment.

community Andrew Schulz stated he had been using a ‘’hair pill’’ for 15 years and it may have caused him infertility

in Satire 134 upvotes 1 year ago

The conversation discusses the potential link between hair loss treatment pills, specifically finasteride, and infertility. Users share their experiences and opinions, with some suggesting that finasteride can temporarily lower sperm count, while others argue that other factors like age and lifestyle could also contribute to infertility.

community White Rice Lowers DHT and might cause post finasteride syndrome

in Finasteride/Dutasteride 2 years ago

White rice may lower DHT and potentially cause symptoms similar to post-finasteride syndrome. The user experienced muscle wasting, depression, and other symptoms after consuming large amounts of white rice.

community Why do people go to Turkey to get a hair transplant to the point that it became a meme?

in Transplants 108 upvotes 3 weeks ago

Turkey is a popular destination for hair transplants due to lower costs, but quality varies, and many clinics are scams. It's crucial to research and select reputable clinics to ensure good results.

community Is anybody here combining oral dutasteride with topical dutasteride?

in Finasteride/Dutasteride 9 upvotes 5 months ago

A user is considering combining oral and topical dutasteride to lower scalp DHT more effectively and is seeking advice on this approach. They are thinking about doing a patch test on their mid scalp.

community 2 month progress on diluted hims spray.

in Progress Pictures 306 upvotes 9 months ago

A user diluted a Hims spray with Kirkland's minoxidil to lower finasteride concentration and has been applying it for nearly 3 months, noticing baby hairs at the temples. They also use a dermastamp, saw palmetto, and biotin supplements, and are seeking advice on their hair loss stage.

community Lowering scalp prolactine - Any ideas ?

in Treatment 2 upvotes 1 year ago

The conversation is about finding the best method to lower scalp prolactine, with suggestions like P5P and Melatonin. The user also mentions HMI115 as a potential treatment and seeks feedback from those who have tried these methods.

community Why Cant we just find an effective androgen receptor antagonist that works locally on the scalp?

in Research/Science 1 year ago

Researching and developing an effective local antagonist to block the androgen receptors for hair loss, as opposed to using DHT synthesis inhibitors that lower serum DHT levels. Several treatments such as CosmeRNA and Pyrilutamide are currently in development or undergoing trials.

community From the research study: "Dihydrotestosterone and the concept of 5a-reductase inhibition in human benign prostatic hyperplasia" - G. Bartsch, R.S. Rittmaster, H. Klocker (2002) in the "World Journal of Urology".

in Research/Science 23 upvotes 2 years ago

Dutasteride is a stronger 5AR inhibitor than finasteride and can significantly lower DHT levels. Reduced doses of dutasteride may lower side effects.

community Similar 5ar inhibitors to fin?

in Finasteride/Dutasteride 3 years ago

Natural vitamins like pumpkin seed oil, saw palmetto, and ecklonia cava are discussed for their potential to lower DHT levels. They may work similarly to finasteride but are significantly weaker.

community Just got brand name Avodart when I ordered generic

in Finasteride/Dutasteride 122 upvotes 4 months ago

A user received brand name Avodart instead of generic dutasteride for a lower price. Another user mentioned experiencing depression as a side effect but prefers having hair.

community Will minoxidil not work if there’s too much DHT present in the scalp?

in Minoxidil 5 upvotes 10 months ago

The user has been using topical finasteride and minoxidil for five months with little progress and is considering oral dutasteride to lower DHT levels, questioning if minoxidil is more effective with reduced DHT. They also use microneedling and tretinoin in their treatment routine.

community A Complete Guide to Hair Loss for Beginners

in Research/Science 525 upvotes 1 year ago

The conversation is a guide on treating hair loss, discussing finasteride and dutasteride to lower DHT, minoxidil for growth, ketoconazole shampoo for scalp health, and dermarolling for regeneration. RU58841 is mentioned as a DHT blocker but not recommended due to safety concerns.

community Does ashwagandha improve or worsen MPB hair loss

in Chat 1 upvotes 1 year ago

The post discusses the impact of Ashwagandha on hair loss, highlighting its ability to lower stress levels, which is beneficial for hair health. However, there's uncertainty about its potential to increase testosterone and DHT, which could contribute to hair loss.