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Did you mean Lipid Nanoparticles?

Glossary Lipid Nanoparticles

tiny, fat-based carriers used to deliver drugs into cells

Lipid Nanoparticles (LNPs) are tiny, spherical particles made from lipids, which are fat-like molecules. They are used to deliver drugs, including genetic material like mRNA, directly into cells. This technology is crucial in modern medicine, such as in the development of mRNA vaccines for COVID-19, because it protects the therapeutic material and ensures it reaches the target cells effectively.

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community We already know how to permanently fix hair loss. The science is done. The only thing missing is the funding to run one experiment.

in Technology 613 upvotes 4 months ago

A permanent hair loss solution could involve reprogramming hair follicles to resist DHT using mRNA and siRNA. However, high costs, safety concerns, and the pharmaceutical industry's preference for ongoing treatments over one-time cures are major obstacles, with finasteride and minoxidil remaining standard treatments.

community Peptides that Stop Hair Loss? | In-depth Literature Review Video

76 upvotes 2 years ago

Peptides like TB500, KPV, GHK-CU, and BPC-157 are overhyped for hair growth with limited proven effectiveness in humans. Combining peptides with delivery methods like iontophoresis and sonophoresis shows promise, but many claims remain unproven.

community Stopping min on scalp - psoriasis

in Minoxidil 35 upvotes 1 year ago

A user with mild psoriasis on the scalp is using finasteride, topical minoxidil, and dermarolling for hair loss but plans to stop minoxidil on the crown due to psoriasis aggravation. Suggestions include switching to a lipid-based minoxidil, using Ketoconazole shampoo, or trying oral minoxidil.

community Hair Loss & Lipids: Why you have sebderm, folliculitis, LPP, inflammation, etc...

131 upvotes 1 year ago

Excess sebum rich in cholesterol and triglycerides can lead to hair loss through inflammation, with treatments like Ciclopirox shampoo, Benzoyl Peroxide shampoo, and Clindamycin gel recommended for managing conditions like seborrheic dermatitis and folliculitis. Pioglitazone is suggested for Lichen Planopilaris, while Omega-3s and reducing processed foods may improve sebum quality, though genetic factors play a significant role.

community DUPA/Retrograde might not be DHT based...GET A BIOPSY QUICK or permanent Hair Loss!

41 upvotes 1 year ago

DUPA and retrograde alopecia may not be solely DHT-based, and a biopsy is crucial for accurate diagnosis and treatment. Treatments mentioned include dutasteride, oral minoxidil, pioglitazone, clobetasol, calcipotriol, ketoconazole, and doxycycline, depending on the specific condition.

community Why everyone should be using topical Dutasteride

45 upvotes 3 months ago

Topical Dutasteride, especially in a liposomal base, is recommended for enhanced scalp DHT suppression when used with oral Dutasteride. It is suggested to apply it twice a week for effective results without significant systemic impact.

community Is 0.1%w/v topical fin overkill if taking oral 0.5mg fin?

in Finasteride/Dutasteride 2 upvotes 7 months ago

The conversation discusses whether using 0.1% topical finasteride alongside 0.5 mg oral finasteride is excessive, with suggestions to choose either oral or topical treatment. The user also uses 5% minoxidil and mentions concerns about alcohol-based solutions due to seborrheic dermatitis.

community My personal experience/observations fighting AGA seriously for 5 years

50 upvotes 1 year ago

Minoxidil with alcohol and propylene glycol was more effective than non-alcohol versions, and RU58841 worked best in a non-water-based solution. Oral finasteride showed better results than topical, despite side effects; microneedling and tretinoin worsened hair loss, and PRP was only helpful when younger.

community Haircafe: Are dutasteride tablets less effective than dutasteride gel capsules?

in Finasteride/Dutasteride 38 upvotes 1 year ago

Dutasteride tablets are less effective than softgel capsules because they require a fat-based environment for proper absorption. Softgel capsules, like Avodart, are designed to maximize bioavailability, while powdered tablets may result in significantly lower DHT suppression.

community Topical fin - why are people still using alcohol carriers when liposomal is proven to be better?

7 upvotes 1 year ago

Liposomal carriers for topical finasteride offer better targeting, reduced side effects, and less irritation compared to alcohol-based solutions, but availability and cost may limit their use. Minoxidil can dissolve in liposomal carriers, enhancing delivery and stability.

community Topical Finasteride Minoxidil: Experience/Price/Research

3 upvotes 7 years ago

Topical finasteride combined with minoxidil is used for hair loss treatment, with some users experiencing fewer side effects compared to oral finasteride. Morr-F, a topical solution, shows better results than minoxidil alone, with minimal adverse effects reported.

community Do botanical oils actually improve absorption in a minoxidil and finasteride topical?

2 upvotes 1 month ago

A user is using a pharmacy-compounded topical treatment for hair loss containing minoxidil, finasteride, azelaic acid, caffeine, and an oil blend including argan, jojoba, castor, rosemary, tea tree, and nettle oils. They are questioning if the oil blend improves absorption of the active ingredients compared to a simple alcohol/propylene glycol solution.

community Topical Finasteride that doesn’t go systematic is the cure

3 upvotes 1 year ago

Topical finasteride that doesn't penetrate the skin could potentially treat hair loss without side effects. Current challenges include finding a formulation that remains on the scalp without increasing blood levels.

community Hydrophobic Finasteride. Why don’t we have it?

6 upvotes 1 year ago

The conversation discusses the potential benefits of creating a hydrophobic version of finasteride to reduce systemic side effects while maintaining scalp health. It compares this idea to fluridil, which is designed to be hydrophobic and has less systemic absorption.

community Why you can still look forward to PP405 and JXL-069

22 upvotes 1 month ago

PP405 and JXL-069 are the same compound, but users experienced no results due to flawed application methods. The topical gel formulation of PP405 is designed to target hair follicle stem cells effectively, unlike liquid solutions that fail to penetrate deeply.

community 25M | 10 years of gradual hair loss | Minoxidil user | Looking for input on treatment optimization before HT

4 upvotes 9 months ago

A 25-year-old male with 10 years of hair loss is using minoxidil and considering adding finasteride or dutasteride, possibly with microneedling, to improve hair regrowth before a hair transplant. Community members suggest starting a DHT blocker immediately, considering oral minoxidil, and addressing low vitamin D and HDL levels.

community Creatine, my hair loss, and my DHT levels. An anecdote with lab values.

165 upvotes 1 year ago

Increased hair loss after starting a 10g daily creatine regimen, possibly linked to elevated DHT levels despite dutasteride use. Stopping creatine reduced shedding, but the exact cause is uncertain, with discussions on exercise and lifestyle impacts.

community Is this legitimate dutasteride?

in Finasteride/Dutasteride 18 upvotes 2 months ago

Dutasteride tablets are considered legitimate and effective, though some users believe gel capsules may be more effective. The conversation discusses the legitimacy of tablets from stop99bald and the differences in bioavailability between tablet and gel forms.

community Interpreting pre-finisteride blood panels

2 upvotes 1 year ago

The conversation is about someone planning to start finasteride for hair loss and wanting to interpret pre-treatment blood panels to assess the risk of side effects like gynecomastia. They list various tests to measure hormone levels and other health indicators.

community What are your thoughts on pre-finasteride blood work?

1 upvotes 3 years ago

The user is considering resuming finasteride after a 6-month break and is debating the necessity of extensive blood work, including hormone and health markers, to establish a baseline. They are unsure if the tests are necessary since they experienced no side effects previously.

community Topical Dutasteride Experiment

1 upvotes 2 months ago

The user is experimenting with a homemade topical dutasteride formulation to reduce hair loss while minimizing systemic absorption, using MCT oil, almond oil, vitamin E, tea tree oil, and lavender oil. They are monitoring hair growth and side effects, particularly focusing on sexual health, and are open to feedback on their approach.

community 18 months Dut - Shed after shed without any gains

in Update 115 upvotes 1 year ago

Dutasteride caused persistent hair shedding and no improvement for 18 months, leading to a switch back to finasteride. The user also uses oral minoxidil and plans to focus on better scalp health.

community Four months on dutasteride/minoxidil oral

68 upvotes 2 weeks ago

A 44-year-old has been using a combination of oral dutasteride (0.5mg), minoxidil (2.5mg), and biotin (10mg) daily for four months, noticing hair regrowth with some concern about side effects like numbness. Another user increased their dutasteride dose from 0.5mg to 1mg, reporting significant hair growth without side effects.

community DHT Itch and Oily Scalp Explained (and how to fix it)

90 upvotes 3 months ago

Malassezia overgrowth can worsen oily scalp and inflammation, contributing to hair loss. Treatments include antifungal shampoos, C6/C8 MCT oil, low-dose isotretinoin, finasteride, and dutasteride.

community Male pattern baldness is not cosmetic.

224 upvotes 9 months ago

Male pattern baldness is linked to health risks and should be treated medically. Finasteride is effective and should be insurance-covered.

community How finasteride lowers brain's happiness steroid allopregnanolone and causes depression: systemic dihydroprogesterone crosses blood brain barrier, you don't even need finasteride and brain 5ar for that

288 upvotes 1 year ago

Finasteride may lower allopregnanolone levels, potentially affecting mood, but many users report improved mental health due to reduced hair loss. Experiences with finasteride and dutasteride vary, with some experiencing side effects and others finding them beneficial for hair retention and overall happiness.

community DHT Harms Scalp Microbiome: DHT Itch is REAL

413 upvotes 1 year ago

Increased Malassezia and Cutibacterium in the scalp microbiome are linked to higher sebum production and inflammation in androgenetic alopecia (AGA). Treatments include ciclopirox shampoo, benzoyl peroxide shampoo, clobetasol propionate, calcipotriol, minoxidil, finasteride, and dutasteride.

community He used Dutasteride for 20 years. Interview

113 upvotes 1 year ago

Dutasteride has been used for 20 years with some hair thickness improvement but no dramatic regrowth. The user also experimented with minoxidil, tretinoin, and peptides like BPC 157 for potential benefits in hair density and quality.

community Androgenetic alopecia is a skin disease: DHT-mediated skin disorders

63 upvotes 2 years ago

Dihydrotestosterone (DHT) impacts various skin conditions, including Androgenetic alopecia and seborrheic dermatitis, by causing overactivity in sebaceous glands. Topical medications Tacrolimus and Clobetasol can reduce these inflammatory conditions, and treatments like RU58841, Minoxidil, and Finasteride may also be beneficial.

community A warning to those thinking about using Dutasteride

in Finasteride/Dutasteride 99 upvotes 6 years ago

The potential risks of long-term use of Dutasteride and how it may be linked to elevated liver enzymes, cholesterol levels, and decreased testosterone. Alternative treatments such as Finasteride and RU58841 were also discussed.