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Glossary Genotype

genetic composition influencing traits and characteristics

Genotype refers to the genetic makeup of an organism, specifically the set of genes it carries. It determines various traits and characteristics, such as eye color or susceptibility to certain diseases, by influencing how the organism's cells function and develop. For example, in the context of hair, a person's genotype can influence whether they are predisposed to conditions like alopecia.

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community Could male-pattern baldness have a secondary photobiological function? The Solar Window Hypothesis

11 upvotes 2 weeks ago

Male-pattern baldness might increase UVB exposure on the scalp, potentially affecting vitamin D and skeletal health. The hypothesis is debated, with some seeing it as a minor benefit in specific contexts.

community Dutasteride: More Than a DHT Reducer – A Potential Androgen Receptor Inhibitor?

in Finasteride/Dutasteride 31 upvotes 1 year ago

Dutasteride may inhibit androgen receptors in addition to reducing DHT, potentially explaining its effectiveness over finasteride for hair loss. Concerns about its impact on muscle growth are debated, with some suggesting no significant effects.

community I don’t think my hair loss is caused by DHT – quitting finasteride after 3 months (1 mg). Need opinions

6 months ago

The user plans to stop finasteride after three months, believing hair loss isn't due to DHT, and will continue with oral minoxidil, microneedling, and ketoconazole shampoo. They suspect stress and poor nutrition are the main causes and seek opinions on DHT blockers' effectiveness.

community Minoxidil works only with Retinoic acid

314 upvotes 1 year ago

Minoxidil is more effective when combined with retinoic acid, such as tretinoin or tazarotene, enhancing hair growth. Some users experience significant regrowth, while others see minimal effects or side effects.

community 30-Min Dermatology Visit – Best Questions to Ask About Balding? ( 175$ )

6 upvotes 1 year ago

The conversation discusses hair loss treatments, focusing on finasteride, minoxidil, and other options like PRP and ketoconazole. It highlights the importance of asking specific questions during a dermatology visit to determine the cause of hair loss and appropriate treatments.

community Why do so many people trash on finasteride?

in Chat 247 upvotes 1 year ago

Finasteride is effective for hair regrowth, especially on the crown, but can cause side effects like reduced libido and erectile dysfunction in some users. Opinions are mixed, with some reporting positive results without side effects and others experiencing significant issues.

community Results of topical minoxidil 3 months

in Progress Pictures 67 upvotes 1 year ago

The user experienced significant hair regrowth using topical minoxidil but faced issues with gynecomastia when using oral minoxidil and finasteride. They plan to have surgery for gynecomastia and consider using finasteride again, while questioning if minoxidil alone can maintain hair growth.

community MBP without genetics? HELP lol

1 upvotes 5 years ago

community Anagenic is trying to compound Gt20029

57 upvotes 3 years ago

The conversation discusses concerns that Anagenic's version of GT20029 might not be as effective or safe as Kintor's, with comparisons to issues faced by pyrilutamide. The chemical structure of the drug has been published.

community Genetic variations associated with response to Dutasteride. Why is it never mentioned?

in Research/Science 26 upvotes 1 year ago

Genetic variations influence how people respond to dutasteride for hair loss, with some benefiting more from finasteride. Dutasteride is effective for most, but genetic differences may cause it to be less effective for some.

community DNA Testing by Roots by Genetic Arts

4 upvotes 2 years ago

A user shared their positive experience with Roots by GA, a company that creates personalized hair loss treatments based on DNA analysis, which confirmed their inability to tolerate finasteride. The user is satisfied with their progress 30 days after a hair transplant and the customized formula they received.

community Tried my best to learn the genetics of male pattern balding

2 upvotes 3 months ago

Male pattern balding is influenced by genetic mutations on several chromosomes, affecting DHT sensitivity, hair pattern, and follicle resilience. Treatments mentioned include Minoxidil, finasteride, and RU58841.

community if sensitivity to DHT is genetic then what caused that gene in the 1st place?

1 upvotes 3 years ago

The conversation discusses the causes of male pattern baldness, questioning the role of DHT sensitivity and suggesting stress, energy levels, and hormonal imbalances as potential factors. Treatments mentioned include Minoxidil, finasteride, and RU58841, with some users skeptical about the genetic explanation for hair loss.

community CRISPR treatment for AGA on the horizon after approval for blood disorders

10 upvotes 2 years ago

CRISPR treatments for blood disorders have been approved, leading to discussions about its potential for treating hair loss (AGA). A study showed that editing a gene related to DHT sensitivity could lead to hair regrowth, suggesting CRISPR may eventually be used for AGA, but it's expected to be expensive and not soon available.

community Is trichogram a good thing for testing genetic hair loss

2 upvotes 6 months ago

A dermatologist checked for hereditary hair loss using blood tests and plans to perform a trichogram. The user had slightly low Vitamin D3 levels, and the trichogram may help confirm androgenetic alopecia.

community Genomic Sequencing for Hair Loss

in Research/Science 156 upvotes 5 months ago

Hair loss treatments like Minoxidil, finasteride, and potential mRNA therapies are discussed. There is skepticism about targeting specific genes due to the complex genetic nature of hair loss.

community actors that i don't think they ever used fin or min, they just have good gens

in Chat 581 upvotes 1 year ago

Some actors are believed to use treatments like finasteride, minoxidil, or hair transplants to maintain their hair, while others are thought to have naturally good genetics. Opinions vary on whether celebrities like Brad Pitt have natural hair or use enhancements.

community This guy won the jackpot in the hair genetics lottery. He had to pay the taxes (white hair) though

2089 upvotes 1 year ago

A man with thick, white hair is admired for his genetics, leading to discussions about hair loss and the preference for white hair over balding. Some speculate about the use of treatments like finasteride.

community Possible transgenerational effects of finasteride use on male offspring? (STUDY)

in Research/Science 27 upvotes 4 months ago

Finasteride may affect male offspring's fertility and hormonal balance, with debates on whether to discontinue use before conception. Some users report no issues, while others highlight the high doses used in rat studies.

community Do we know exactly why some people respond so great to dut/fin,min and others dont?

in Research/Science 29 upvotes 1 year ago

Genetic factors, enzyme activity, and DHT sensitivity affect individual responses to hair loss treatments like finasteride, minoxidil, and dutasteride. Starting treatments early can slow hair loss, but results vary among individuals.

community Will GT20029 results be permanent?

3 upvotes 3 years ago

GT20029 may not permanently destroy androgen receptors, requiring ongoing application for hair maintenance. Concerns exist about potential systemic effects if androgen receptors are permanently degraded.

community Losing the genetic lottery - venting

in Chat 67 upvotes 4 months ago

The user is experiencing hair loss and has tried various treatments including topical and oral finasteride, minoxidil, dutasteride, and ketoconazole, but continues to lose hair. They are considering alternative solutions like hair systems due to the lack of improvement and a scalp condition called CVG.

community DNA Test for better suited treatment?

3 upvotes 11 months ago

The conversation is about hair loss treatments, specifically discussing the use of dutasteride, minoxidil, and the potential benefits of a DNA test and PRP therapy. Opinions vary, with some users skeptical about the DNA test and PRP, suggesting sticking with current treatments.

community GT20029 and gains from fin and min

1 upvotes 2 years ago

GT20029 may maintain gains from finasteride but not from minoxidil. Finasteride and GT20029 work similarly by reducing androgenic effects, while minoxidil promotes hair growth through different mechanisms.

community How a follicle next to it is so genetically different that it never miniaturized??

in Chat 219 upvotes 11 months ago

Genetic differences in hair follicles affect hair loss patterns. Treatments discussed include finasteride, dutasteride, minoxidil, and RU58841.

community Genetics are so weird and unpredictable

in Minoxidil 118 upvotes 1 year ago

The user experienced male pattern baldness starting at 18, tried finasteride with no success, and switched to dutasteride, which halted hair loss. Minoxidil had no effect for them, while their brother, who didn't use AR inhibitors, maintained a juvenile hairline and successfully grew a beard with minoxidil, highlighting the unpredictable nature of genetics in hair loss and treatment response.

community Modifiability of the aging process

17 upvotes 3 months ago

Hair loss is largely influenced by genetics, with treatments like finasteride, minoxidil, and RU58841 being used to manage it. Despite healthy lifestyles, hair loss can still occur, highlighting the complex relationship between genetics, health, and aging.

community A man in his 80s with full head of hair.

473 upvotes 4 months ago

Genetics play a major role in hair loss, with some people keeping a full head of hair into old age without using treatments like minoxidil or finasteride. Many express frustration over their own hair loss and the perceived unfairness of genetic differences.

community GT20029 & KX826 Major Updates from Kintor.

101 upvotes 1 year ago

KX826 shows promise as a hair loss treatment with a 10% increase in hair count, but concerns about Kintor's marketing practices and the systemic effects of treatments like GT20029 and RU58841 remain. Users express skepticism and hope, with some preferring traditional treatments like finasteride and minoxidil.

community Help interpreting pre-fin bloodwork

12 upvotes 5 years ago

A 20-year-old male is unsure how to interpret his bloodwork results and whether he should take finasteride for hair loss. His bloodwork shows borderline high levels of albumin and testosterone, and high progesterone, but normal levels of other hormones.