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The conversation is about the effects of grape seed extract on hair, with mixed experiences reported. One user advises against using it.

The conversation discusses the approval of Kintor Pharmaceutical's AR-PROTAC (GT20029) for clinical trials in China for acne and androgenic alopecia. One user expresses optimism about new treatments being developed and seeks clarification on how the new drug works, specifically if it temporarily degrades the AR protein to reduce DHT sensitivity in hair follicles.

Low-dose topical finasteride may reduce scalp DHT with fewer side effects than oral finasteride, though it can still lower blood serum DHT. Users report varying experiences, with some finding topical use effective and side-effect-free, while others note significant DHT suppression.

The user experienced hair regrowth using finasteride, oral and topical minoxidil, and RU58841, despite initial shedding. They also transitioned from finasteride to dutasteride and addressed scalp issues with a folliculitis shampoo.

Oral minoxidil has shown positive results for hair regrowth, but concerns about its side effects, such as heart issues, are noted. Adding a DHT blocker like finasteride is recommended for better and more lasting results.

A user has been on finasteride for 4 months, experiencing persistent hair shedding despite improvements. Others suggest adding keto shampoo and note that shedding is normal.

The user regained most of their hair using Minoxidil, Finasteride, and Dermarolling. They found Dermarolling particularly effective, as it promotes growth factors and improves hair thickness.

User shared 4.5-month hair loss treatment results using Fin, Minoxidil, and microneedling. Others discussed postponing hair transplant and adjusting microneedling depth.

Hair loss discussion includes various causes like DHT, blood flow, and skin fibrosis. Treatments mentioned are Minoxidil, Finasteride, and RU58841.

Akinfenrawr experienced negative side effects from oral finasteride and RU58841, and is seeking alternative hair loss treatments. They discuss various options, including raloxifene, oral dutasteride, liposomal finasteride, Breezula, Pyrilutamide, SM04554, and sulforaphane, but have concerns about efficacy, availability, and cost.

The post discusses using a topical tincture containing zinc, azelaic acid, and other ingredients to inhibit 5 alpha-reductase activity for treating hair loss. The user plans to try this natural alternative before using finasteride or RU58841.

Dutasteride may inhibit androgen receptors in addition to reducing DHT, potentially explaining its effectiveness over finasteride for hair loss. Concerns about its impact on muscle growth are debated, with some suggesting no significant effects.

A user experienced significant hair regrowth using dutasteride without side effects, starting with finasteride and not using minoxidil or dermarolling. They attributed success to a unique genetic response to DHT blockers but did not share their full regimen, frustrating others.

A 24-year-old user tried finasteride, oral minoxidil, and dutasteride for hair loss but saw no improvement and was advised by their dermatologist to accept baldness. Other users suggested alternative treatments like RU58841, pyrilutamide, microneedling, and checking for underlying conditions or lifestyle factors.

A 20-year-old reports worsening hair loss despite using dutasteride and minoxidil, and considers a hair transplant. Users suggest continuing treatments, trying microneedling, ketoconazole shampoo, switching to finasteride, or adding tretinoin.

A user is struggling with hair loss at 17 and has been using finasteride for 5 months and minoxidil for 11 months without seeing regrowth. Other users encourage continuing treatment, sharing their own experiences with finasteride, minoxidil, and dermarolling, and emphasizing patience and acceptance.

A user shared their 11-year experience with spironolactone and nearly 5 years with finasteride for hair loss, recently adding oral minoxidil and stopping birth control. Various treatments were discussed, including organic options, checking for underlying health issues, considering dutasteride, and the potential role of progesterone in hair loss.

Some people find topical minoxidil effective for hair loss, but oral minoxidil doesn't work for them, possibly due to absorption issues. Others have had better results with oral minoxidil, suggesting individual responses vary.

Some people see significant hair regrowth using treatments like finasteride and minoxidil, while others experience little to no improvement even with comprehensive treatment plans. Factors such as individual sensitivity to DHT may influence the effectiveness of these hair loss treatments.

Natural remedies like rosemary oil, coconut oil, and onion juice are generally seen as less effective compared to medical treatments like finasteride, minoxidil, and microneedling. Some users believe natural oils can help, but modern medicine is often more reliable.

The conclusion of the conversation is that the user, Michael_Scott1234, has been using topical minoxidil for a long time and recently started using oral finasteride and dermarolling. They have not experienced any side effects from finasteride and are happy with their progress.

Hair loss and potential treatments, primarily focusing on Finasteride and Minoxidil. Other solutions discussed include PRP, dermarolling, LLP, and scalp tension relief.

User reports almost 2 months on DUT and MIN for hair loss with positive results. Treatment includes 0.5mg dut (morning), 5mg oral min (night), and vitamin D and B12 supplements.

A user using finasteride and dutasteride to treat hair loss, but still losing hair rapidly after stopping minoxidil. Replies suggest that the user should try oral minoxidil or switch to dutasteride for better results.

A user (seblt) who has had side effects from finasteride, minoxidil and RU58841 but is now trying pyrilutamide as a last resort, with other users providing advice and support. They have already seen some baby hairs growing after 10-14 days of treatment and will provide updates in 1-2 weeks.

Hair loss and scalp issues, with people discussing possible treatments such as Nizoral shampoo, Minoxidil, neem oil, and finasteride.

First patient dosed with Pyrilutamide (Kintor) Phase III for hair loss treatment. Pyrilutamide differs from approved treatments as it competes with DHT to bind hair follicles, potentially reducing side effects.

Hair regrowth treatment involving 3aHSD enzyme shows 6% improvement in 18 weeks. Sulforaphane, L-Menthol, and Dexpanthenol are potential ingredients for new hair loss solution.

The conversation discusses the tension theory as a cause of male pattern baldness (MPB), suggesting that scalp tension and reduced subcutaneous fat layer contribute to hair loss. Treatments mentioned include Minoxidil, finasteride, microneedling, scalp massages, and Botox.

Treatments used to prevent and treat male pattern baldness, the difficulty in finding a permanent cure for hair loss, and the potential financial motivations of companies not wanting to find a cure.