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      FCE 28260: A Forgotten 5α-Reductase Inhibitor

      community FCE 28260: A Forgotten 5α-Reductase Inhibitor

      in Research  330 upvotes 3 months ago
      FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.

      community Topical Dutasteride. Does it work?

      in Finasteride/Dutasteride  13 upvotes 5 months ago
      Topical dutasteride may be effective for hair loss by staying in the scalp and minimizing bloodstream absorption, potentially improving hair results and reducing side effects. The user seeks advice on its effectiveness.

      community Diffuse thinning is the worst man

      in Chat  248 upvotes 10 months ago
      The conversation is about the struggles of dealing with diffuse thinning at a young age and the lack of significant improvement after using treatments like finasteride and minoxidil. Some suggest additional methods like derma rolling, microneedling, and hair fibers, while others share their own experiences and encourage persistence with treatment.

      community Atherosclerosis as cause of balding and treatment

      in Treatment  61 upvotes 1 year ago
      Hair loss may be caused by calcification of capillaries in the scalp, restricting blood flow to hair follicles. A daily treatment regimen including high doses of Vitamins D and K, Magnesium, and Nattokinase could potentially decalcify these capillaries, improving blood flow and hair growth. However, some users warn against excessive Vitamin D intake and emphasize the need for medical consultation.

      community Achievement Unlocked: Regrow Hairline

      in Progress Pictures  270 upvotes 2 years ago
      FluffyyKoala shared their 6-month hair regrowth journey using finasteride, minoxidil, and microneedling, with positive results and minimal side effects. Others in the conversation shared their experiences, asked questions, and congratulated FluffyyKoala on their progress.

      community 1 Year progress on topical fin and min

      in Progress Pictures  735 upvotes 3 years ago
      User shares 1-year progress using topical finasteride and minoxidil for hair loss, with positive results. Some users discuss trying topical dutasteride and varying dosages, while others share their experiences and ask about specific products.

      community Losing hair everywhere, idk what to do :(

       29 upvotes 5 years ago
      A 22-year-old male has been experiencing widespread hair loss for over four years, including pain and significant shedding. Treatments tried include ketoconazole shampoo, fluocinonide topical solution, biotin, ACV, and dry shampoo, but none have been effective.

      community 7 Week Progress Pic or am I tripping?

      in Is this regrowth?  22 upvotes 1 month ago
      A 40-year-old using 1mg finasteride daily reports noticeable hair regrowth in 7 weeks and plans to start 5% minoxidil and microneedling. Feedback is mixed, with some seeing progress and others suggesting a hair transplant.

      community 1 Year Later - Dutasteride + Minoxidil Foam

      in Progress Pictures  82 upvotes 6 months ago
      A user shared progress pictures showing significant hair regrowth and thickness after one year of using Dutasteride and Minoxidil Foam. They mentioned regrowing hair on their temples and achieving the thickest hair since high school.

      community 7 months progress. fin 1.25 mg, oral min 2.5 mg, keto shampoo, micro-needling once per month. M/32

      in Progress Pictures  82 upvotes 7 months ago
      A user shared a 7-month hair loss treatment progress using finasteride 1.25 mg, oral minoxidil 2.5 mg, ketoconazole shampoo, and monthly micro-needling, noting denser hair and improved quality but no significant regrowth. They experienced mild testicular discomfort and heart palpitations, considering switching to topical minoxidil to avoid side effects.

      community Using Minoxidil without Finasteride

      in Minoxidil 1 year ago
      The effectiveness of using minoxidil alone as a hair loss treatment, and whether or not finasteride should be taken in addition to the minoxidil. Replies suggest that minoxidil is only effective for a short period of time, and finasteride should be added to the treatment plan.

      community God bless H&M's fitting room lighting

      in Chat  197 upvotes 3 years ago
      Diffuse thinners find shopping challenging due to harsh overhead lighting, but H&M's side lighting in fitting rooms is more flattering. Many users humorously suggest banning overhead lighting to improve the shopping experience.

      community I wish I'd kept on treatment 4 years earlier...

      in Chat  28 upvotes 11 months ago
      The user regrets not continuing hair loss treatment with finasteride earlier and plans to restart it along with minoxidil. Another user suggests trying dutasteride and oral minoxidil as a more effective treatment.

      community fin 0.5 mg everday 6 months update

      in Finasteride/Dutasteride  28 upvotes 1 year ago
      The post discusses the experiences of individuals with diffuse hair thinning using finasteride, with many reporting no improvement or worsening conditions after 6 months. Various suggestions include persisting with the treatment, checking for underlying conditions, adding minoxidil for volume, adjusting dosage, and considering other potential causes like autoimmune responses and inflammation.

      community This and ketoconazole 2% life changing

      in Ketoconazole  69 upvotes 1 year ago
      The post discusses the user's experience with hair loss treatment using finasteride, clobetasol propionate, and ketoconazole shampoo. The conversation warns about the potential side effects of clobetasol, a powerful topical steroid, and emphasizes its short-term usage.

      community What you look like 2 years after scalp micropigmentation

      in SMP  194 upvotes 2 years ago
      Scalp micropigmentation as a treatment for hair loss, and the importance of choosing a reputable practitioner to get a natural look. Different treatments such as laser removal were also discussed in relation to long-term maintenance.