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Glossary Cyclooxygenase-2

enzyme involved in inflammation and pain production

Cyclooxygenase-2 (COX-2) is an enzyme that plays a crucial role in the inflammatory process by converting arachidonic acid into prostaglandins, which are compounds that mediate inflammation and pain. Unlike its counterpart COX-1, which is expressed constantly in most tissues, COX-2 is typically induced during inflammation and is a target for anti-inflammatory drugs like NSAIDs (nonsteroidal anti-inflammatory drugs).

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community Brotzu lotion update

87 upvotes 8 years ago

A new hair loss lotion by Dr. Brotzu, expected to regrow up to 5 years of lost hair, is set to be released by Fidia Farmaceutici. It claims to work like minoxidil and finasteride without side effects, but skepticism exists due to its classification as a cosmetic product.

community OND-1 "Cyclosporine A” New hair loss treatment

in Research/Science 28 upvotes 5 months ago

Orient Bio is developing a PLGA formulated version of Cyclosporine A to stimulate hair growth without its immunosuppressant effects. Users discuss various treatments like Clascoterone, PP405, minoxidil, and tacrolimus, expressing hope for new developments and sharing personal experiences with these treatments.

community RU and cetosomal minoxidil topical

1 upvotes 7 months ago

Mixing RU58841 with cetosomal minoxidil is discussed due to scalp irritation from ethanol PG vehicles. A mixture of the two turned bright pink when left to dry.

community Oxytocin Pathway and Cinnamic Acid Research

14 upvotes 2 years ago

The conversation discusses the potential of cinnamic acid for hair growth. It also mentions treatments like Minoxidil, finasteride, and RU58841.

community Ketoconazole vs Ciclopirox which one was better for you ?

3 upvotes 1 year ago

Switching from ketoconazole to a ciclopirox and zinc pyrithione shampoo significantly reduced hair fall. The user is considering whether to continue using ketoconazole occasionally or combine both shampoos weekly.

community An Uncontrolled Case Series Using a Botanically Derived, β-Cyclodextrin Inclusion Complex in Two Androgenetic Alopecia-Affected Male Subjects

1 upvotes 5 years ago

The conversation discusses a botanically derived treatment for androgenetic alopecia using ingredients like saw palmetto, green tea, and evening primrose, showing impressive results over 270 days. Concerns include the study's uncontrolled nature and potential product motivation, with suggestions to enhance absorption through derma rolling.

community Stemoxydine bad for collagen?

2 upvotes 2 years ago

Concerns about stemoxydine potentially inhibiting collagen synthesis. The user uses oral finasteride and ketoconazole shampoo for hair loss.

community Serioxyl - stemoxydine - not containing stemoxydine in ingredients??

in Product 3 upvotes 1 year ago

The conversation is about a product called Serioxyl, which was expected to contain stemoxydine. It clarifies that Diethyl lutidinate is another name for stemoxydine.

community Selling KY19382 powder a novel activator of Wnt/β-catenin signaling

4 years ago

The conversation is about selling KY19382 powder, a novel activator of Wnt/β-catenin signaling, and Kolliphor EL liquid for vehicle formulation. The seller offers worldwide shipping.

community JXL082 is not PP405 and Everychem followed the wrong lead

41 upvotes 1 year ago

JXL082 is not the same as PP405, leading to a halt in sales and a plan to synthesize the real PP405. There is skepticism about the safety and effectiveness of JXL082 and PP405, with concerns about patent issues and the long-term impact on hair growth.

community Is stemoxydine (serioxyl advanced) toxic/lethal to cats?

in Chat 1 upvotes 1 year ago

The conversation is about concerns regarding the safety of using stemoxydine (Serioxyl Advanced) around cats, with the user also using minoxidil, oral minoxidil, dutasteride, and microneedling for hair loss. The user is seeking advice on whether stemoxydine is toxic or lethal to cats.

community CoQ10 and Fish Oil body hair growth

5 upvotes 1 year ago

Taking CoQ10 and fish oil supplements may lead to increased body hair growth and a crawling sensation on the scalp and skin. The user suspects these supplements could be linked to hair growth, possibly due to their effects on heart health and cholesterol management.

community Im struggling with sebderm need help

3 upvotes 6 months ago

The user is struggling with seborrheic dermatitis and plans to try ciclopirox olamine after finding ketoconazole too drying. They are also using finasteride daily.

community Has anyone tried CB-01-03 aka Clascoterone?

2 upvotes 6 months ago

Clascoterone, a topical anti-androgen, is generating interest for potentially fewer systemic side effects. Users are curious about its effectiveness and details like concentration and duration of use.

community Where do you guys get your stemoxydine from?

2 upvotes 1 year ago

Stemoxydine is available in L'Oréal's Serioxyl and Dercos Neogenic products, which can be found on Amazon, Ulta, or L'Oréal's website. A user is selling three bottles of L'Oréal Stemoxydine.

community Diy dutesteride please help MCT oil or PG?

1 upvotes 9 months ago

A user is making their own dutasteride solution using MCT oil but is concerned about its effectiveness and bioavailability. They are considering using propylene glycol or adding ethanol for better results, while others suggest the current dosage might be excessive.

community Insane Idea: Cyperus Rotundus Oil?

in Research/Science 9 upvotes 1 year ago

Cyperus rotundus oil is suggested as a natural treatment for androgenic alopecia, potentially inhibiting hair growth without affecting testosterone levels. The conversation questions its effectiveness and safety for scalp use.

community How to mix raw Clascoterone (CB-03-01)?

7 upvotes 2 months ago

Mixing clascoterone with minoxidil involves using 99% ethanol and propylene glycol. Users discuss the effectiveness and potential side effects of this DIY solution.

community Is Stemoxydine a DHT blocker.?

2 upvotes 1 year ago

Stemoxydine is not a DHT blocker; it works independently to stimulate hair growth. Users discussed its function and clarified it does not block DHT.

community Anybody using piroctone olamine instead of ketoconazole shampoo?

4 upvotes 1 month ago

OP is considering switching from ketoconazole shampoo to piroctone olamine (PTO) due to scalp irritation. Users report mixed experiences, with some finding PTO less irritating and more soothing than ketoconazole.

community Forgotten 'Total Revival' Stack

in Research/Science 42 upvotes 1 year ago

Cyclosporine A is discussed as a powerful hair growth stimulant, potentially more effective than minoxidil, but concerns about safety and side effects, including cancer risk, limit its use. The conversation highlights the need for further research and experimentation with topical application, despite its risks.

community kx826 .05% month 8 | topical minoxidil .5% month 21 combo update.

in Progress Pictures 6 upvotes 1 year ago

The user used finasteride but stopped due to side effects, then used topical minoxidil for 13 months, and later added KX826/pyrilutamide for 8 months. They experienced shedding after starting pyrilutamide and use minoxidil and KX826 once daily.

community Anyone knows if koshine kx-826 has propylene glicol?

11 months ago

Koshine KX-826 has different versions, and the green version uses a plant-based carrier that may be less irritating for those sensitive to propylene glycol. Users report irritation with some versions of KX-826.

community topical cetirizine to control scalp inflammation

4 upvotes 4 years ago

The user applies a topical solution containing minoxidil, finasteride, dutasteride, retinoic acid, and hydrocortisone to address scalp inflammation and is considering adding cetirizine to the mix. They are calculating the correct amount of cetirizine to add to their formula and have paused this approach to retry oral minoxidil.

community What’s the view on stemoxydine?

6 upvotes 1 year ago

Stemoxydine may work synergistically with minoxidil and finasteride for hair growth, but its effectiveness is debated, with some users experiencing minimal results and concerns about cost. Users suggest sticking to proven treatments like minoxidil and finasteride, while considering stemoxydine as an additional option.

community Adding caffeine to topical minoxidil

4 upvotes 1 year ago

Adding caffeine to topical minoxidil is unlikely to enhance its effectiveness, with most users agreeing it has minimal impact. The main treatments discussed are minoxidil and finasteride, with some users adding other ingredients like azelaic acid and retinol.

community What do you think about this prescription

2 years ago

The user visited a trichologist due to ineffective topical finasteride treatment for hair loss. The trichologist recommended a new regimen including a two-month course of locoidon (cortisone 0.1%), followed by a solution containing minoxidil, hydrocortisone butirrate, estrone, progesterone, tocopherol acetate, trichosol, and transcutol.

community Serioxyl / Stemoxydine no longer available

4 upvotes 3 years ago

Stemoxydine is no longer available on Amazon in the US, and users discuss alternatives for making topical finasteride. OP cannot use minoxidil due to side effects and seeks other solutions.

community Ordered copper peptides - how to apply?

in Treatment 1 upvotes 2 years ago

Gizzela is unsure about the dosage and frequency of copper peptides and asks if they can be used with Stemoxydine. They seek advice on applying these treatments together.

community DLQ01: A Better "Minoxidil" PGF2a synthetic analogue.

3 upvotes 1 year ago

DLQ01, a prostaglandin F2α analog, shows promise for hair growth by directly stimulating PGE2/PGF receptors without needing conversion, and can be combined with minoxidil and retinoids like tretinoin for enhanced effectiveness. Minoxidil's efficacy may be reduced by COX-1 inhibitors, but using prostaglandin analogs like Latanoprost or Bimatoprost can help maintain its effectiveness.