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    GlossaryCluster of Differentiation (CD)

    system for identifying cell surface molecules, especially on white blood cells

    Cluster of Differentiation (CD) refers to a system used to identify and classify surface molecules on cells, particularly white blood cells, which are critical for the immune system. These molecules serve as markers that help differentiate between various cell types and their functions, and are often used in medical diagnostics and research to understand immune responses and diseases.

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      FCE 28260: A Forgotten 5α-Reductase Inhibitor

      community FCE 28260: A Forgotten 5α-Reductase Inhibitor

      in Research  330 upvotes 2 months ago
      FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.

      community Oxytocin, empathy, hair, and cinnamon

      in General  87 upvotes 3 months ago
      Low oxytocin levels in hair are linked to reduced empathy and may affect hair growth. Cinnamic acid can promote hair growth by activating oxytocin receptors.
      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 3 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.
      Improvements, features, announcements

      community Improvements, features, announcements

      in General  169 upvotes 5 months ago
      The conversation discusses improvements to a platform and mentions hair loss treatments including Minoxidil, finasteride, RU58841, and melatonin. It also highlights the addition of features like Google login, reply by email, keyword extraction, and a term glossary for better understanding of hair-related terminologies.

      community I hate what my hair does to me!

      in Chat  32 upvotes 6 months ago
      The conversation is about a person struggling with inconsistent hair styling due to thinning hair, despite being on hair loss medications. They find that ketoconazole 2% shampoo helps, but conditioning makes their hair look worse; others suggest staying consistent with treatment and using hair fibers for events.

      community Progress: 0.5mg finasteride + 2.5 mg oral minoxidil

      in Progress Pictures  431 upvotes 1 year ago
      This user uses a combination of finasteride and oral minoxidil to treat hair loss, and reports that the treatment has had an impact on his growth without any major side effects. He also shares advice on how to obtain the necessary medications in certain countries.

      community 5 Months Results - Fin/Min/Keto Shampoo/Dermapen

      in Progress Pictures  719 upvotes 1 year ago
      Treatments for hair loss, including using finasteride and minoxidil regularly, together with keto shampoo and dermapen; the user's progress since starting treatment five months ago; and discussion of potential side effects.
      The story of RU58841/ PSK3841

      community The story of RU58841/ PSK3841

      in Research  622 upvotes 3 months ago
      RU58841, a potential hair loss treatment, was not commercialized due to marketability issues and lack of long-term safety data. Concerns about its formulation and delivery methods further complicate its use.
      Is this a male pattern baldness or diffuse baldness?

      community Is this a male pattern baldness or diffuse baldness?

      in General  144 upvotes 3 months ago
      A 23-year-old male experienced sudden hair loss over six months, losing about 30% of his hair. Treatments include 10% minoxidil, a hair spray, and a vitamin pill; opinions on the cause vary between normal hair loss due to deficiencies and male pattern baldness.
      TresslessGPT is now available for free

      community TresslessGPT is now available for free

      in General  386 upvotes 5 months ago
      Tressless GPT is now free and accessible for hair loss advice. Treatments discussed include Minoxidil, finasteride, RU58841, dutasteride mesotherapy, topical melatonin, microneedling, and rapamycin.

      community Can HMI-115 reverse miniaturization?

      in Research/Science  13 upvotes 1 year ago
      HMI-115, a potential treatment for hair loss that can reverse miniaturization and make individual hairs thicker, as evidenced by data from macaques given the treatment and one subject in the phase I trial.

      community New Treatments, and a Huge Group Buy with Lots of Research

      in Research/Science  109 upvotes 1 year ago
      A user is organizing a group buy for various compounds aimed at reversing hair loss and gray hair, and improving brain health and fat loss. The user has developed a treatment plan based on extensive research and is inviting others to participate, with the option to choose only the compounds they need.
      Topical Dutasteride - Non-Hormonal, Side Effect Free 5ARI?

      community Topical Dutasteride - Non-Hormonal, Side Effect Free 5ARI?

      in Treatments  372 upvotes 3 months ago
      Topical dutasteride is suggested as a low side-effect treatment for hair loss, with a proposed dose of 0.025% 1ml/day. It is considered better than finasteride due to its even inhibition of DHT isoforms and lower systemic absorption.

      community Getting Ed from 1mg of fin not sure what to do

      in Finasteride  190 upvotes 3 months ago
      The user experienced erectile dysfunction from 1mg finasteride and sought advice on whether to continue, reduce dosage, or switch treatments. Suggestions included switching to topical finasteride, adding minoxidil, or trying dutasteride.

      community Ru58841 for a female w male pattern baldness

      in General  166 upvotes 3 months ago
      A user is considering using RU58841 for female pattern baldness and is also planning to use Minoxidil. They are hesitant to ask their doctor for spironolactone due to its cosmetic nature and are experiencing significant hair loss possibly due to stress and hormonal issues.

      community Seeking Advice on Microneedling and Hair Care Post-Treatment

      in Microneedling  2 upvotes 1 year ago
      The user plans to use an electric microneedling pen for hair loss, set to penetrate 0.6mm to 0.8mm, and apply rosemary oil in jojoba oil post-treatment. They also intend to use 5% Minoxidil daily, followed by a blend of rosemary, peppermint, and jojoba oils.

      community Any other non-responders to most medications?

      in Finasteride/Dutasteride  6 upvotes 1 year ago
      The user has not seen results from various hair loss treatments including finasteride, dutasteride, minoxidil, and others over several years and is considering adding RU58841 and starting hormone replacement therapy. They are also experiencing anxiety and contemplating moving to a more accepting environment for their nonbinary identity.