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GlossaryBioavailability

proportion of a substance that enters the bloodstream and works

Bioavailability refers to the proportion of a drug or other substance that enters the bloodstream when introduced into the body and is thus able to have an active effect. For example, if you take a vitamin pill, bioavailability determines how much of that vitamin actually gets absorbed and used by your body, rather than being excreted. This concept is crucial in pharmacology and nutrition because it affects the efficacy of medications and supplements.

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community 500mg pill of dutesteride ? Will I become Jesus him self ?

in Satire 53 upvotes 3 weeks ago

The conversation humorously discusses the exaggerated effects of taking a 500mg pill of dutasteride, with users joking about extreme side effects like excessive hair growth and loss of sensation. It also mentions personal experiences with finasteride and the potential high bioavailability of dutasteride in liquid form.

community Sublingual Minoxidil - Cure to Hairloss?

in Minoxidil 583 upvotes 1 year ago

The conversation discusses the potential benefits of sublingual minoxidil for hair loss treatment. It suggests that sublingual minoxidil, which bypasses the liver, may have fewer side effects, greater bioavailability, and could be more effective than oral minoxidil.

community Take The Jump - Get The Hair Transplant

in Progress Pictures 338 upvotes 1 year ago

User got a hair transplant and it improved their life. Transplanted hair lasts, but medication like finasteride is needed to maintain non-transplanted hair.

community From the research study: "Dihydrotestosterone and the concept of 5a-reductase inhibition in human benign prostatic hyperplasia" - G. Bartsch, R.S. Rittmaster, H. Klocker (2002) in the "World Journal of Urology".

in Research/Science 23 upvotes 2 years ago

Dutasteride is a stronger 5AR inhibitor than finasteride and can significantly lower DHT levels. Reduced doses of dutasteride may lower side effects.

community hair loss treatment myths that perplex me

in Treatment 8 upvotes 1 month ago

Grapefruit juice doesn't significantly affect finasteride or dutasteride. Drinking topical minoxidil is risky; saw palmetto is less effective than finasteride or dutasteride for hair loss.

community Fin 3xweek and dermarolling since end of April – October

in Progress Pictures 124 upvotes 2 years ago

A user's progress with finasteride and dermarolling to regrow their hairline, with other users noting the improvement.

community About to add topical melatonin to my 5% minoxidil solution. What's would be the right concentration?

in Research/Science 13 upvotes 3 years ago

The user added melatonin to their 5% minoxidil solution for hair growth, using a concentration of 0.0033%, which equates to roughly 2mg for a 60ml bottle. They later reported no significant difference and planned to continue the treatment for a few more months before potentially stopping to observe any changes in shedding.

community Minoxidil Sulfate makes everyone a responder

in Research/Science 255 upvotes 1 week ago

Minoxidil sulfate is more effective than regular minoxidil, especially for those with low sulfotransferase levels or scalp sensitivity, but it is unstable unless delivered in a liposomal format. Combining minoxidil with tretinoin can enhance effectiveness, and stopping minoxidil use can lead to rapid hair loss.

community Peptides that Stop Hair Loss? | In-depth Literature Review Video

in Research/Science 71 upvotes 4 months ago

Peptides like TB500, KPV, GHK-CU, and BPC-157 are overhyped for hair growth with limited proven effectiveness in humans. Combining peptides with delivery methods like iontophoresis and sonophoresis shows promise, but many claims remain unproven.

community How is it possible for someone to be a non responder to ORAL minoxidil?

in Minoxidil 66 upvotes 7 months ago

Some individuals do not respond to oral minoxidil for hair loss, despite it generally working by improving blood flow to hair follicles. Factors like metabolism, drug interactions, and individual variations in the drug's activation may influence its effectiveness.

community Can a folate deficiency make androgenetic alopecia worse?

in Treatment 1 upvotes 10 months ago

The user is treating androgenetic alopecia with finasteride and discovered a folic acid deficiency. They are asking if curing the deficiency can worsen or improve their hair condition.

community I wish I'd kept on treatment 4 years earlier...

in Chat 28 upvotes 11 months ago

The user regrets not continuing hair loss treatment with finasteride earlier and plans to restart it along with minoxidil. Another user suggests trying dutasteride and oral minoxidil as a more effective treatment.

community No side effects on pyrilutamide / KX-826 so far

in Research/Science 207 upvotes 3 years ago

User TopBack56 and friends tried pyrilutamide (KX-826) for hair loss without experiencing negative side effects. They observed fine vellus hairs but no thick hair growth yet, and plan to add GT20029 to their regime after safety trials.

community Going to try the theory posted here for the next 3-6 months

in Treatment 187 upvotes 3 years ago

User xEternex tries hair regrowth with daily broccoli sprouts, apple extract containing procyanidin b2, and microneedling. Others discuss potential issues with the experiment and share their experiences with vegetable consumption and hair growth.

community Red Ginseng Extract Promotes the Hair Growth in Cultured Human Hair Follicles

17 upvotes 6 years ago

The conversation is about hair loss treatments, specifically discussing the effectiveness of Red Ginseng Extract in promoting hair growth. Other treatments mentioned include Minoxidil, finasteride, and RU58841.

community i think i have finally found my retrogade alopecia triggers

in Finasteride/Dutasteride 8 upvotes 4 months ago

The user experienced severe scalp itching and hair loss while on dutasteride, which they linked to caffeine and masturbation. They plan to cut out both to see if their hair density improves.

community PSA: You guys are paying way too much for your Finasteride and Minoxidil. Here's the cheapest I've found.

in Product 223 upvotes 4 months ago

Finasteride and minoxidil can be obtained cheaply through Mark Cuban's Cost Plus Drugs and Costco's Kirkland brand, respectively, costing about $7.53/month combined. Amazon's RXPass and virtual visits at Dr. B. offer additional savings.

community Why don’t people just just DUT instead of FIN?

in Finasteride/Dutasteride 48 upvotes 9 months ago

The conversation discusses the use of dutasteride (DUT) versus finasteride (FIN) for hair loss treatment, with some users preferring DUT for its effectiveness while others choose FIN due to its approval status, better long-term data, and lower risk of side effects. Users share personal experiences with both medications, including side effects and effectiveness.

community Diffuse thinning fucking sucks

in Update 430 upvotes 9 months ago

The conversation discusses various treatments for hair loss, including finasteride, minoxidil, dutasteride, microneedling, and checking for nutrient deficiencies. Some users suggest adding hydrocortisone butyrate, low-dose progesterone, or tretinoin to treatment regimens, while others recommend cosmetic solutions like Toppik hair fibers or shaving the head.

community Fats on your Head to Stop Hair Loss?

in Research/Science 138 upvotes 9 months ago

The conversation discusses the potential of long-chain unsaturated fatty acids, like oleic and linoleic acid, as an additional treatment for hair loss, which may inhibit the enzyme responsible for converting testosterone to DHT and promote hair growth. Users humorously suggest using oils topically and discuss other hair loss treatments, but the main focus is on the science behind fatty acids and their role in hair health.

community Why nobody uses 0.25% (2.5mg/ml)?

in Treatment 65 upvotes 10 months ago

The conversation is about the effectiveness of 0.25% topical finasteride compared to other concentrations and forms. Users discuss its potential for better scalp DHT reduction and fewer side effects, with some preferring topical over oral treatments.

community Dutasteride SAVES your hair follicles: MAJOR BS on people who say it destroyed their hair permanently.

in Finasteride/Dutasteride 156 upvotes 11 months ago

The conversation discusses the effectiveness of hair loss treatments, specifically finasteride and dutasteride. The conclusion is that dutasteride significantly reduces DHT levels and may be more effective than finasteride for long-term hair retention, with some users reporting personal experiences and side effects.

community Dutasteride 2 years 3 month results

in Finasteride/Dutasteride 251 upvotes 1 year ago

The user tried dutasteride for hair loss for 2.5 years but experienced drastic thinning and receding hairline. They decided to switch back to finasteride, along with minoxidil, LLLT, and ketoconazole, due to dissatisfaction with dutasteride's results and side effects.

community Are there ever going to be any oral DHT blocking treatments in the future?

in Product 6 upvotes 1 year ago

The discussion revolves around the need for future oral DHT blockers for hair loss treatment that don't have the side effects of current options like Finasteride and Dutasteride. One user suggests that the future of hair loss treatment will likely be topical anti-androgens, as they can target hair follicles without affecting the entire system.

community Minoxidil seems to not work anymore this sucks

in Progress Pictures 32 upvotes 1 year ago

A user reported that Minoxidil, a hair growth treatment, stopped working for them despite initial success. Other users suggested not taking breaks from the treatment, checking for fake products, trying microneedling, using oral Minoxidil, combining Minoxidil with tretinoin, and using finasteride.

community Dutasteride 6 months - Should I quit or wait more?

in Finasteride/Dutasteride 11 upvotes 1 year ago

The user has been on dutasteride for 6 months, experiencing initial hair health but then shedding and brittle hair, with no improvement. They use minoxidil, ketoconazole, dutasteride, and vitamin D, and are questioning whether to continue treatment despite no results.

community How to BECOME a RESPONDER to Fin/Dut if you are not responding

in Finasteride/Dutasteride 305 upvotes 1 year ago

The conclusion of this conversation is that the user "DuckSeasonCamelSeasn" found that consuming grapefruit juice prior to taking finasteride or dutasteride helped them become a responder to the medications and regain hair growth. However, there are warnings about potential risks and interactions with other medications, so caution should be exercised.

community Insane hair regrowth 5 weeks on zinc, Vitamin D, Biotin (PLEASE READ CAPTIONS AND POST) - My zinc deficiency caused a receding hairline as well as diffuse miniaturization similar to DUPA

in Progress Pictures 47 upvotes 1 year ago

A user experienced significant hair regrowth after 5 weeks by taking zinc, vitamin D, and biotin supplements, correcting deficiencies that were contributing to hair loss and thinning. They report a decrease in hair shedding, faster hair growth, and a thickening of their hairline without using common hair loss medications like Minoxidil or Finasteride.

community Looks like a real cure to the root of baldness (DHT-induced senescence) was proven earlier this year

in Research/Science 732 upvotes 2 years ago

A study that outlines the full model for androgenic alopecia (AGA) which links DHT to cellular senescence in dermal papilla cells, and suggests black chokeberry as a source of cyanidin 3-O-arabinoside polyphenol with potential anti-oxidant properties that could reverse this process. The post encourages reaching out to experts in anti-aging and longevity to research treatments involving the polyphenol.

community Let’s do this! 90 minoxidil pills for £79 and 168 finasteride pills for £58.95. Fuckin expensive but hopefully worth it.

in Update 2 years ago

This conversation is about various treatments for hair loss, including taking Oral Minoxidil and Finasteride pills. It discusses different prices and sources of these medications in different countries.