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Glossary Collagen

protein providing structure and strength to connective tissues

Collagen is a protein that serves as a key structural component in various connective tissues, including skin, hair, nails, bones, and tendons. It provides strength and elasticity, helping to maintain the integrity and resilience of these tissues. As we age, collagen production decreases, which can lead to signs of aging such as wrinkles and weakened joints.

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Research

5 / 1000+ results

research The distributions of type IV collagen .ALPHA. chains in basement membranes of human epidermis and skin appendages

36 citations , January 2007 in “Archives of Histology and Cytology”

This study suggests that the absence of alpha5(IV)/alpha6(IV) chains in certain subepidermal basement membrane spots may relate to interactions with melanocytes in human skin.

research Lack of Collagen VI Promotes Wound-Induced Hair Growth

32 citations , May 2015 in “Journal of Investigative Dermatology”

This study found that collagen VI influences hair follicle growth and wound-induced regrowth by activating the Wnt/β-catenin signaling pathway in mice, suggesting potential therapeutic targets for hair loss.

research Synergistic Effects of Fractional CO ₂ Laser and Recombinant Humanized Type III Collagen (rhCol III) in Atrophic Acne Scar Treatment: Activation of MAPK Pathway and Enhanced Collagen Remodeling

January 2025 in “Dermatologic Therapy”

In this study, treatment with fractional CO2 laser combined with recombinant humanized type III collagen led to significantly better improvements in atrophic acne scars compared to laser treatment with saline, attributed to collagen upregulation and MAPK pathway activation in human dermal fibroblasts.

research Perturbations in fatty acid metabolism and collagen production infer pathogenicity of a novel MBTPS2 variant in Osteogenesis imperfecta

1 citations , May 2023 in “Frontiers in endocrinology”

The researchers reported that the novel MBTPS2 variant p.Glu172Asp found in a male proband is likely pathogenic, consistent with osteogenesis imperfecta symptoms and molecular signatures, including disrupted fatty acid metabolism and collagen production.

research Collagen Involvement in Health, Disease, and Medicine

1 citations , March 2022 in “IntechOpen eBooks”

This chapter discusses various aspects of collagen, proposing "extended collagen carential disease" as a new concept tied to nutritional deficiencies, notably Vitamin C's role in maintaining collagen health.

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Community Join

5 / 532 results

community Is there any good collagen to use for skin, nails, hair, and joints?

2 upvotes 2 months ago

Collagen supplements for improving skin, hair, nails, and joints. Recommendations include standard collagen peptide powder and Live Conscious collagen peptide, though some users doubt their effectiveness.

community Inhibition of collagen synthesis, oral versus topical minoxidil

4 upvotes 3 years ago

The conversation discusses the use of oral versus topical minoxidil for hairline recession, with concerns about collagen synthesis inhibition. Oral minoxidil may affect collagen production more broadly, while topical minoxidil's effects are localized but may cause skin issues.

community If minoxidil inhibits collagen production, what does it do when it drips down your face during exercise?

in Minoxidil 4 upvotes 7 years ago

Minoxidil may inhibit collagen production, raising concerns about its effects when it drips down the face during exercise. It's suggested to apply minoxidil before bed and wash it out before exercising.

community Will minoxidil cause your skin to age from the collagen inhibition?

2 upvotes 7 months ago

Minoxidil is unlikely to cause skin aging at typical doses, and concerns about collagen inhibition are mostly unfounded. Users suggest using sunscreen and tretinoin for skin health, and some combine minoxidil with finasteride for hair maintenance.

community Minoxidil inhibits lysyl hydroxylase which is needed to produce collagen. If I take 2,5...5 mg of minoxidil every day can I cause my skin to age prematurely?

32 upvotes 1 year ago

Oral minoxidil is effective for hair loss and unlikely to significantly affect collagen synthesis, making it a safe option without causing premature skin aging. Users report positive hair regrowth without noticeable skin aging.

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Learn

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learn nonspecific group of soluble collagens

learn Vitamin C

Why is Vitamin C important for hair and hair follicles? Vitamin C is needed for collagen synthesis, antioxidant defense and iron absorption, all of which matter for hair follicles. Extra vitamin C has not been shown to improve hair in people who are not deficient.

learn Centella

Can a centella (gotu kola) supplement help hair loss from a poor diet? What the evidence says There is no published human trial showing that an oral Centella asiatica (gotu kola) supplement stops hair shedding caused by poor nutrition; the evidence is laboratory work on dermal papilla cells, inflammation and collagen, and community reports mention centella only in topical products.

learn Microneedling

Technique that makes tiny punctures in the scalp with fine needles

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