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This study reported cold thermal injuries on the scalp in four patients using cold caps to prevent chemotherapy-induced alopecia, suggesting improper application can lead to adverse events.

In this study, manual cold capping was found to be effective in minimizing chemotherapy-induced alopecia, with 92.1% of patients retaining 50% or more of their hair, although effectiveness varied with different chemotherapy regimens.

This study will evaluate the clinical efficacy, patient-reported outcomes, and economic impact of the PAXMAN® PSCS 2 automated scalp cooling system versus standard cold-cap therapy to prevent chemotherapy-induced hair loss in women with localized breast cancer during anthracycline and taxane treatment.

This study found that indirect treatment with cold atmospheric plasma showed promise for improving androgenetic alopecia in patients, laying the groundwork for longer trials to assess its efficacy.

This review discusses recent advancements in cold atmospheric plasma therapies for dermatology, covering optimization, treatment of skin diseases, safety, and does not report new clinical outcomes; it calls for continued research in the field.