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research Clinical Translation of Targeted Protein Degraders

40 citations , July 2023 in “Clinical Pharmacology & Therapeutics”

This review discusses the progress and challenges of targeted protein degradation therapies, highlighting the increasing number of degraders in cancer clinical trials and the limited diversity in targeted proteins, primarily focusing on those employing CRL4^CRBN as the E3 ligase.

research Clinical Translation of Microbiome Research in Alopecia Areata: A New Perspective?

2 citations , May 2022 in “Cosmetics”

This review explores the potential roles of the gut and skin microbiome in alopecia areata, suggesting topical and systemic strategies for managing the condition, but it reports no new clinical results.

research Clinical translational research on stem cell products: prospects and challenges

1 citations , May 2026 in “Signal Transduction and Targeted Therapy”

This review highlights the promising role of stem cell therapy in treating resistant diseases, while also addressing the challenges in production and clinical application, emphasizing the need for standardized manufacturing and quality assurance to enhance efficacy and safety in clinical translational research.

research Polycystic ovary syndrome (PCOS) trilogy: a translational and clinical review

26 citations , August 2008 in “Clinical endocrinology”

This paper summarizes proceedings from a PCOS Special Interest Group, reporting recent advances in the understanding of PCOS follicular abnormalities, associated cardiovascular risks, and dermatological issues, but does not present new clinical findings.

research Bulge Progenitor Cells: A Promising Frontier in Hair Follicle Regeneration and Clinical Translation

September 2026 in “Stem Cell Reviews and Reports”

Bulge progenitor cells show promise for regenerating hair follicles and increasing hair density.

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Community Join

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community New Hair Loss Cure: AMP-303 Is Back. It’s what PP405 should have been.

7 upvotes 5 months ago

AMP-303 and AMP-601 are new hair loss treatments targeting dermal papilla cells, with AMP-303 showing early efficacy in transitioning vellus hairs to terminal hairs after one injection. Further clinical trials are planned, and these treatments are seen as promising due to their biologic approach and less frequent application compared to daily treatments.

community Guaranteed Way to Revive ALL Follicles. Transition, and then Transition Back & Maintain (for Men)

250 upvotes 1 year ago

Transitioning genders humorously suggested for hair regrowth, noting some transgender individuals experience this. Discusses treatments like minoxidil, finasteride, and hormone therapy, but advises against transitioning solely for hair regrowth.

community My 1.5-year journey: Transitioning from Finasteride/Topical to Dutasteride + Oral Minoxidil (5mg)

171 upvotes 2 months ago

The user transitioned from finasteride and topical minoxidil to dutasteride and oral minoxidil, increasing the oral minoxidil dose to 5mg, which led to shedding but also new hair growth. They found oral treatments more effective and convenient, despite initial shedding, and are seeking advice on long-term results and experiences with similar transitions.

community Eirion Therapeutics Announces Potential Breakthrough Treatment for Hair Loss Based on First-in-Man Clinical Trial Results

in Update 415 upvotes 1 year ago

ET-02, a new hair loss treatment, shows promising results with a 6-fold increase in hair count, potentially outperforming minoxidil by activating stem cells in hair follicles. Further trials are ongoing to confirm its efficacy and safety, with potential market release in the future.

community The new growth in hair loss research: With increasing evidence of its impact on mental health, scientists are pushing forward with breakthroughs on balding. Later this year, scientists will launch one of the first ever clinical trials with hair follicles grown entirely from stem cells.

324 upvotes 7 years ago

Hair loss impacts mental health, with treatments like Minoxidil, finasteride, and stem cell transplants discussed. There is hope for future breakthroughs, but current treatments are limited, and awareness is lacking.

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Learn

8 / 801 results

learn PP405

mitochondrial pyruvate carrier (MPC) inhibitor by Pelage in early trials

learn Exosomes

Microscopic delivery system that sends growth-promoting signals to hair follicles

learn SCUBE3

a signaling molecule from dermal papilla cells being actively researched

What do clinical trials say about the safety and effectiveness of SCUBE3 for hair regrowth? No clinical trial of SCUBE3 for hair regrowth has been registered on ClinicalTrials.gov or published, so there is no human safety or effectiveness data. The evidence is limited to one 2022 laboratory and mouse study reporting that SCUBE3 activates hair follicle stem cells through TGF-beta signalling.

learn Rapamycin

mTOR regulator and immunosuppressant used more recently for anti-aging and hair regrowth

learn Follistatin

glycoprotein that inhibits TGF-β and promotes hair growth by antagonizing activin

Are there any clinical studies supporting follistatin as a hair loss treatment? There is no controlled human trial showing follistatin treats hair loss; the published work is mouse and laboratory biology on the activin/follistatin signalling system, plus one small 2011 phase 1 injection study of a combination product, so follistatin remains experimental and unapproved.

learn KY19382

Are there clinical studies showing that KY19382 can regrow hair in androgenic alopecia? No clinical studies have proven KY19382 regrows hair in androgenic alopecia.

learn Tofacitinib

What types of hair loss conditions are most commonly associated with tofacitinib use in clinical settings? Published studies link tofacitinib mainly to alopecia areata and its severe variants — as an off-label drug being studied for them, not as a cause of hair loss. The evidence is mostly small, open-label or retrospective, and relapse after stopping is commonly reported.

learn GT20029

When will GT20029 be commercially available, and are there any clinical trials on its use? GT20029 is not approved or commercially available anywhere and remains investigational. A published 12-week Phase II study in 180 Chinese men reports hair-count gains over placebo, but no long-term or Phase III data exists, so any launch is years away at best.

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