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43 citations , October 1955 in “The journal of nutrition/The Journal of nutrition”

Germ-free rats need biotin for growth and have different vitamin metabolism compared to regular rats.

155 citations , August 1991 in “Journal of The American Academy of Dermatology”

Methotrexate treats various disorders by inhibiting DNA synthesis, but careful monitoring is needed to avoid toxicity and manage side effects.

3 citations , June 1983 in “Archives of Dermatology”

Aminopterin effectively improves skin conditions but has toxic side effects that need careful monitoring.

114 citations , December 1951 in “Archives of Dermatology”

Aminopterin strongly suppresses epithelial tissues and can treat certain skin conditions but has significant side effects.

March 1965 in “Hospital Topics”

Chemotherapy provides symptom relief and extends life in 30-50% of gynecological cancer cases, but has only cured choriocarcinoma.

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