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research 1320 Orchestrated cytotoxic and skin migratory ability lacking self-tolerance: circulating γδT-cells may promote alopecia areata

April 2018 in “Journal of Investigative Dermatology”

This study found that terminally differentiated effector memory Vδ1T-cells and their cytotoxic activation markers were elevated in alopecia areata patients, suggesting these cells may contribute to its early pathogenesis.

research 319 Novel Circulating Natural Killer Cell Subset as Biomarkers in Alopecia Areata Progression

November 2024 in “Journal of Investigative Dermatology”

Certain NK cell changes in blood may indicate alopecia areata progression.

research Skin CD4+ memory T cells exhibit combined cluster-mediated retention and equilibration with the circulation

155 citations , May 2016 in “Nature communications”

This study found that mouse skin CD4(+) memory T cells are in equilibrium with the circulation under steady state but increase in specific clusters in response to infection or inflammation.

research Platelets and Pro-Angiogenic Circulating Cells Accelerate Skin Wound Healing

January 2021 in “Research Square (Research Square)”

This study observed that combining PRP with pro-angiogenic cells (Angio PRP) enhanced wound healing in a mouse model by promoting keratinocyte proliferation, angiogenesis, and vessel remodeling.

research CYP3A5 Polymorphism in Circulating Tumor Cells Confers an Increased Disease-Free Survival in DLBCL Patients Treated with R-CHOP

March 2025 in “OncoTargets and Therapy”

This study found that in circulating tumor cells from non-invasive liquid biopsies, the GG genotype of the CYP3A5 A6986G affects longer disease-free survival in DLBCL patients, highlighting the significance of circulating biomarkers for prognostic evaluation.

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Community Join

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community "Hair Follicle Stem Cells are quiescent 99% of the time and permanently reside in the hair follicle"

in Research/Science 1391 upvotes 1 year ago

Hair follicles are mostly dormant but can be reactivated with treatments like minoxidil, finasteride, and microneedling. A new drug, PP405, shows promise for hair regrowth but may not be available until 2027-2028.

community Topical Finasteride Doesn't Directly Reduce 5ar Enzyme on Scalp

in Finasteride/Dutasteride 72 upvotes 3 years ago

Topical Finasteride doesn't directly reduce 5ar enzyme on scalp and has the same mechanism as oral, needing to go through the liver. Users debate the accuracy of this information and discuss various studies and experiences.

community Minoxidil doesn’t work over night.

in Is this regrowth? 196 upvotes 1 year ago

Minoxidil requires at least 6 months to show results and may not work for everyone. Combining it with Finasteride can improve outcomes, but stopping Minoxidil can result in losing any regrowth.

community Microneedling must reach the stem cells in the upper hair shaft

82 upvotes 4 years ago

Microneedling should target depths of 0.5mm to 1.5mm for hair loss, with weekly sessions at 1mm recommended. Combining microneedling with Minoxidil is common for improved results.

community Don’t let them scare you from finasteride. 8 months

in Progress Pictures 270 upvotes 2 years ago

A user shared their 8-month progress using 1mg oral finasteride with no side effects and plans to start minoxidil. Another user commented that the results look great and suggested reconsidering starting minoxidil.

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Learn

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learn Centella

Ever wonder why your hair doesn’t grow back thick anymore? Maybe your scalp needs better blood flow: centella could help. There is no clinical trial of centella asiatica for hair loss and no study measuring scalp blood flow in people using it; the only hair-related evidence is a 2017 cell-culture study. Centella products are cosmetics that may soothe an irritated scalp, and the link between scalp circulation and pattern hair loss is itself unproven.

learn Thymosin Beta 4

learn Neem Oil

natural substance from Neem tree with medicinal and pesticidal properties

learn Metformin

Does metformin help control DHT levels that trigger androgenic alopecia? Metformin has been shown to lower circulating androgens in women with PCOS, but no published study has measured scalp DHT, 5-alpha reductase activity in the follicle, or hair density in anyone taking it — so its effect on pattern hair loss is untested, and it is not a DHT blocker.

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