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research Local circadian clock gates cell cycle progression of transient amplifying cells during regenerative hair cycling

116 citations , May 2013 in “Proceedings of the National Academy of Sciences of the United States of America”

This study discovered that the circadian clock influences hair follicle regeneration, making hair grow faster in the morning and causing more radiation-induced hair loss in the morning compared to the evening.

research A Meeting of Two Chronobiological Systems: Circadian Proteins Period1 and BMAL1 Modulate the Human Hair Cycle Clock

92 citations , September 2013 in “Journal of Investigative Dermatology”

This study found that peripheral clock genes, particularly BMAL1 and Period1, modulate human hair follicle cycling, suggesting their potential as therapeutic targets for affecting hair growth.

research Overview of the Circadian Clock in the Hair Follicle Cycle

July 2023 in “Biomolecules”

In this review, the authors discussed how the circadian clock influences hair follicle regeneration by regulating metabolism, suggesting potential new targets for hair loss treatments.

research Estimation methods for human circadian phase by use of peripheral tissues

14 citations , June 2016 in “Hypertension research”

The authors concluded that utilizing clock gene expression from hair follicle cells may improve circadian-phase estimation in clinical settings, aiding the detection of circadian-related sleep problems despite social time constraints.

research Hair Follicles as a Critical Model for Monitoring the Circadian Clock

5 citations , January 2023 in “International Journal of Molecular Sciences”

This review discusses the expression of circadian genes in hair follicles and their potential for monitoring circadian-rhythm-related conditions, reporting no clinical results; the authors suggest combining hair sampling with other assessments for better insight.

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community Circadian rhythm disruption and its potential impact on hair growth cycles

in Technology 7 upvotes 4 months ago

Poor sleep quality may affect hair growth cycles by disrupting the body's natural clock and stress hormones. The focus should be on improving sleep to support overall health, including hair growth, rather than relying solely on treatments like Minoxidil, finasteride, or RU58841.

community Why I Take 5mg Minoxidil at Night Instead of Splitting 2.5mg

9 upvotes 4 months ago

Taking 5mg oral minoxidil at night instead of splitting 2.5mg doses, with the rationale that a single larger dose may provide a stronger activation for hair follicles and reduce peak-related side effects. Some users report sleep issues with nighttime dosing, while others find it beneficial; opinions on effectiveness and side effects vary.

community My Theory Of Androgenic Alopecia

16 upvotes 10 months ago

Hair loss is linked to cellular physiology and the IGF-1 to TGF-B1 ratio, not just androgen sensitivity. The theory lacks evidence, while finasteride and minoxidil are effective treatments.

community Does Creatine Really Increase DHT? My Personal Experiment

115 upvotes 1 year ago

Creatine does not increase DHT levels, but some report hair loss when using it, possibly due to other factors. The effects on hair loss vary individually, with no clear connection established.

community How is dht not beneficial to you?

in Finasteride/Dutasteride 111 upvotes 7 months ago

DHT is important for sexual function and mood, but finasteride and dutasteride can reduce DHT, causing side effects like reduced libido and erectile dysfunction. These treatments are effective for hair loss, but their impact on DHT leads to debate.

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learn Melatonin

Hormone that regulates sleep, sold as a supplement

Clinics

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Hair Loss Treatments
Circadian RejuvenationFayetteville, NC · US

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