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      research Genome-Wide Association Study in Alopecia Areata Implicates Both Innate and Adaptive Immunity

      717 citations, June 2010 in “Nature”
      A genome-wide association study conducted on 1,054 cases and 3,278 controls identified several susceptibility loci for alopecia areata, suggesting the involvement of both innate and adaptive immunity in the disease. The study highlighted significant associations with genes related to regulatory T cells, CTLA4, IL-2/IL-21, IL-2RA, and the HLA region, as well as genes expressed in the hair follicle like PRDX5 and STX17. Notably, the ULBP gene cluster on chromosome 6q25.1, encoding ligands for the natural killer cell receptor NKG2D, was implicated for the first time in autoimmune disease, with ULBP3 expression upregulated in the hair follicle during active disease. This research provided insights into the genetic basis of alopecia areata and suggested a novel mechanism involving ULBP ligand upregulation in autoimmunity.
      Alopecia Areata: Overview and Insights from January 2018

      research Alopecia Areata: Overview and Insights from January 2018

      290 citations, December 2017 in “Journal of The American Academy of Dermatology”
      Alopecia areata is an autoimmune condition causing hair loss, influenced by genetics, stress, and diet, and may be prevented by a high soy oil diet.
      Epidemiology and Burden of Alopecia Areata: A Systematic Review

      research Epidemiology and Burden of Alopecia Areata: A Systematic Review

      144 citations, July 2015 in “Clinical, Cosmetic and Investigational Dermatology”
      Alopecia areata is a common autoimmune disease affecting about 2% of people, causing significant disability and often associated with mental health issues and other autoimmune conditions.
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      community Hair loss and ethnicity - Caucasian men the most likely to experience hair loss

      in Chat  17 upvotes 1 year ago
      The conversation discusses how Caucasian men are more likely to experience hair loss due to genetic predisposition, with factors like the androgen receptor on the X chromosome playing a significant role. The user also expresses confusion about the evolutionary reasons for hair loss, especially in colder climates where it would seem beneficial to retain hair for warmth.

      community Female, 30, PCOS diagnosis, MPB Norwood 2. Endo refuses to give anything other than Spironolactone. Feel like I’m at my wit’s end here.

      in Female  57 upvotes 10 months ago
      A 30-year-old female with PCOS and male pattern baldness is frustrated with her endocrinologist's recommendation of only Spironolactone and minoxidil, feeling that dutasteride, finasteride, and progesterone would be more effective. Other users suggest various online sources for treatments, warn against self-medicating due to potential risks, and recommend seeking a specialized endocrinologist or considering additional treatments like Inositol, Berberine, and dermaneedling.

      community I want to sacrifice my hair in the name of science

      in Chat  12 upvotes 1 year ago
      The conversation discusses various theories of hair loss, including DHT sensitivity and genetic factors, with the user willing to use themselves for research due to having a hair loss gene but different hair loss patterns compared to their brothers. Specific treatments were not mentioned in the provided text.

      community Is there any chance of improvement?

      in Minoxidil  7 upvotes 2 years ago
      A 19-year-old experiencing severe hair loss since 16 is using a treatment regimen of 5% minoxidil, 0.1% finasteride topical solution, 3% procapil hair serum, and 0.5 mg dutasteride daily. They are concerned about the effectiveness and potential shedding phase, with advice suggesting noticeable changes in 6 to 8 months.

      community What the hell happened in my family genes?

      in Chat  116 upvotes 4 months ago
      A user is frustrated about early balding despite older male relatives retaining hair into old age. Another user plans to start finasteride soon to address their hair thinning.
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