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This study found that transcriptional regulation by Runx1 and cyclin-dependent kinase inhibitors plays a crucial role in maintaining quiescence and promoting fate decision flexibility in hair follicle stem cells.

This study found that breast cancer patients treated with CDK4/6 inhibitors plus endocrine therapy experienced more pronounced vertex hair loss and were less responsive to minoxidil treatment compared to those on endocrine monotherapy.

This study found that cyclin-dependent kinase 4/6 inhibitors used for metastatic breast cancer caused alopecia resembling androgenetic alopecia, negatively impacting patients' quality of life, but topical minoxidil showed potential for improvement.

In this study, researchers report that CDK inhibitors like palbociclib and ribociclib, initially developed for cancer therapy, show potential in treating neutrophilic inflammation-related conditions such as ARDS and psoriasis, although their clinical repurposing requires further research on safety and dose adjustments.

This review examines regulatory mechanisms of quiescent stem cells in tissue homeostasis, drawing on observations from the intestine and other self-renewing tissues, without presenting new data.