learn Osteopontin signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss
research Induction of T Cell Exhaustion by JAK1/3 Inhibition in the Treatment of Alopecia Areata 13 citations, September 2022 in “Frontiers in immunology” Ifidancitinib, a JAK inhibitor, effectively regrows hair in mice with alopecia by tiring out harmful T cells.
research Selective Inhibition of JAK3 Signaling Is Sufficient to Reverse Alopecia Areata 42 citations, April 2021 in “JCI insight” Blocking JAK3 signaling can reverse hair loss from alopecia areata.
research CXCR3 Blockade Inhibits T Cell Migration Into the Skin and Prevents Development of Alopecia Areata 64 citations, July 2016 in “Journal of Immunology” Blocking the CXCR3 receptor reduces T cell accumulation in the skin and prevents hair loss in mice.
research The Role of Lymphocytes in the Development and Treatment of Alopecia Areata 60 citations, September 2015 in “Expert Review of Clinical Immunology” Lymphocytes, especially CD8+ T cells, play a key role in causing alopecia areata, and targeting them may lead to new treatments.
research Malt1 Protease Is Critical in Maintaining Function of Regulatory T Cells and May Be a Therapeutic Target for Antitumor Immunity 39 citations, April 2019 in “The journal of immunology/The Journal of immunology” Malt1 protease is essential for regulatory T cell function and could be targeted to boost antitumor immunity.
community The Cure isn't 5 years away; it's already here. in Research/Science 1005 upvotes 6 months ago PP405 is a new topical treatment for hair loss, showing promise in trials but still requires finasteride for maintenance. There is skepticism about its effectiveness and safety, with concerns about needing finasteride to maintain results.