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GlossaryCD4+ T cells

specialized white blood cells that coordinate immune responses

CD4+ T cells, also known as T helper cells, are a type of white blood cell that plays a crucial role in the immune system. They help coordinate the body's response to infections by signaling other immune cells, such as B cells and cytotoxic T cells, to perform their functions. These cells are essential for mounting an effective immune response and are notably targeted by HIV, which can lead to a weakened immune system.

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research Skin CD4+ memory T cells exhibit combined cluster-mediated retention and equilibration with the circulation

155 citations , May 2016 in “Nature communications”

Memory T cells in the skin balance staying put and moving into the blood, clustering around hair follicles, and increasing in number after infection.

research 035 Expansion of bacterial phosphatidylglycerol reactive CD4+ T cells in atopic dermatitis

May 2021 in “Journal of Investigative Dermatology”

People with atopic dermatitis have more CD4+ T cells that respond to a certain bacterial lipid, which may play a role in the skin condition's inflammation.

research Idiopathic CD4+ T-lymphocytopenia

27 citations , September 1992 in “The Lancet”

ICL is a condition with low CD4+ T cells like AIDS but not caused by HIV, and normal CD4+ T cell counts may vary between men and women.

research Cutting Edge: Memory Regulatory T Cells Require IL-7 and Not IL-2 for Their Maintenance in Peripheral Tissues

140 citations , May 2013 in “The journal of immunology/The Journal of immunology”

Memory regulatory T cells need IL-7, not IL-2, to stay in peripheral tissues.

Astilbin Activates the Reactive Oxidative Species/PPARγ Pathway to Suppress Effector CD4+ T Cell Activities via Direct Binding With Cytochrome P450 1B1

research Astilbin Activates the Reactive Oxidative Species/PPARγ Pathway to Suppress Effector CD4+ T Cell Activities via Direct Binding With Cytochrome P450 1B1

1 citations , May 2022 in “Frontiers in Pharmacology”

Astilbin can potentially calm overactive immune responses, like in Type 1 Diabetes, by suppressing certain cell activities and reducing inflammation.

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