research In silico structural prediction of human steroid 5α-reductase type II
This study used homology modeling to create a detailed in silico structure of 5α-reductase type II, suggesting it can aid in designing steroid reductase drugs.
Search
forResearch
5 / 1000+ resultsresearch Structure of human steroid 5α-reductase 2 with the anti-androgen drug finasteride
This study provides the first crystal structure of the human SRD5A2 enzyme, revealing key insights into its function and inhibition which may aid future drug development.
research Natural Product-InspiredBis(trifluoromethyl) PhenylHydroxycinnamate Derivatives as Promising Nonsteroidal Inhibitorsof Human Steroid 5α-Reductase Type-1: Synthesis, InVitro, and In Silico Studies
This study found that hydroxycinnamate derivatives, especially a compound named 10a, effectively inhibited SRD5A1 activity and protein expression in cell assays, suggesting potential for treating androgen-related conditions.
research Structural and dynamic insights into substrate binding and catalysis of human lipocalin prostaglandin D synthase
This study examined the structural and biochemical mechanisms of human lipocalin prostaglandin D synthase, detailing substrate and product binding processes at the catalytic site and suggesting potential for drug delivery targeting hydrophobic molecules.
research Structural & functional studies of L-PGDS and SMPDL3A enzymes in lipid signaling family
This study explored the structure and function of lipocalin prostaglandin D synthase, revealing its dual role in substrate catalysis and as a lipophilic ligand carrier, potentially informing future drug delivery design.
Learn
— no results
Community Join
— no results
Experts
— no results
Clinics
— no results