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research Cinchona pubescens (Cascarilla), Native Species from the Andes Mountains of South America

October 2022 in “CRC Press eBooks”

This review explores the botany, traditional uses, phytochemicals, and pharmacological activities of Cinchona pubescens but presents no new clinical findings.

research The cascading pathogenic consequences of Sarcoptes scabiei infection that manifest in host disease

31 citations , April 2018 in “Royal Society open science”

This study found that mange-infected bare-nosed wombats have increased heat loss, higher metabolic rates, altered behavior, and disrupted fatty acid composition compared to healthy individuals.

research A CLE14 Signalling Cascade Promotes Arabidopsis Root Hair Elongation

3 citations , May 2025 in “Plant Cell & Environment”

This study found that in Arabidopsis, the CLE14 peptide regulates root hair growth by promoting elongation, an effect that requires CLV2 and CRN proteins and involves ethylene signalling along with hydrogen peroxide and nitric oxide pathways.

research The prescribing cascade 3.0: a case for recreational drugs in HIV

2 citations , June 2020 in “AIDS”

This case study describes a severe instance of iatrogenic Cushing's syndrome induced by gamma-hydroxybutyric acid, exacerbated by combined use of betamethasone and anabolic steroids, in an HIV-positive patient on cobicistat-containing therapy.

research Zinc‐Coordinated Trienzyme Nanogel Cascade Therapy for Accelerated Post‐Pancreatectomy Cutaneous Wound Healing

1 citations , July 2025 in “Advanced Materials”

This study reports on a zinc-coordinated tri-enzyme nanogel system (Zn@nGSC) that mimics natural enzymatic processes to enhance enzymatic activity and cascade efficiency, showing potential in wound healing, hyperglycemia treatment, and antibacterial effects in a murine model of post-pancreatectomy.

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Community Join

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community Any concrete cases of people who were told they couldn't have a transplant because of microneedling?

in Hair Systems 26 upvotes 2 years ago

Microneedling before a hair transplant may harden the scalp and affect blood circulation, potentially impacting graft growth. Some users report successful transplants after microneedling, while others advise caution and consulting with a surgeon.

community Why do we have head hair in first place if we evolved to start losing it in some cases as soon as puberty hits

140 upvotes 11 months ago

Hair loss is influenced by genetics and sensitivity to hormones like DHT. Treatments like Minoxidil and finasteride are commonly used, and baldness persists as it doesn't affect reproductive success.

community Why do people on this sub die on the hill that fin/dut doesn't give regrowth in most cases?

in Research/Science 121 upvotes 1 year ago

Finasteride and dutasteride mainly stop hair loss, with little regrowth. Minoxidil is better for regrowth, but results differ per person.

community Oral minoxidl - Is this a medication that's generally safe to take for life? Like what I understand oral fin is? Also do studies show that in general or in a significant amount of more cases that results with oral minox + oral fin > oral fin in terms of long-term use(talkin 20+ years).

in Minoxidil 77 upvotes 1 year ago

Oral minoxidil combined with finasteride can improve hair density, but long-term safety is uncertain due to potential side effects like heart and kidney issues. Users report mixed experiences, with some experiencing side effects and others finding it effective for hair maintenance.

community Chromosome 20’s balding effects and why fin likely isn’t working for some.

in Treatment 96 upvotes 1 year ago

Finasteride is effective for DHT/AR-driven hair loss but not for chromosome 20-driven cases, where treatments like minoxidil, prostaglandin analogs, and low-level laser therapy may be more beneficial. Genetic testing can help determine the underlying cause of hair loss to tailor treatment effectively.

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Learn

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learn Exosomes

What are exosomes and how do they help regenerate hair in cases of severe hair loss? Exosomes are cell-derived vesicles that some clinics promote for hair regrowth. No exosome product is FDA-approved, and human evidence is limited to small, uncontrolled reports.
Do exosomes work for people with mild hair loss or only in advanced cases? There is no approved exosome treatment for hair loss and no controlled trial in either mild or advanced cases; the argument that early thinning would respond better is based on follicle biology, not on results.

learn Pyrilutamide

Can pyrilutamide be used by both men and women, or only in specific cases? Pyrilutamide (KX-826) is an investigational topical anti-androgen that has been trialled in men and women but is not approved for hair loss anywhere. Its sponsor reports one failed (2023) and one successful (2026) Phase III in men, none of it peer-reviewed; long-term safety is unknown, and anti-androgens are not considered appropriate in pregnancy.

learn Hair Transplant

When is a hair transplant not possible? A hair transplant is not possible with insufficient donor hair or serious health conditions.
When can I wear a hat after a hair transplant? Wear a loose-fitting hat after 3 to 10 days, but consult your surgeon first.

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