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natural substance from Neem tree with medicinal and pesticidal properties
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learn PP405
mitochondrial pyruvate carrier (MPC) inhibitor by Pelage in early trials
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herb and oil with stimulant, circulatory, anti-inflammatory and antioxidant properties
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research Unexpectedly High Carrier Rates and Genotype/Phenotype Correlation: LIPH Mutations in Japanese Autosomal Recessive Woolly Hair/Hypotrichosis
Certain gene mutations in Japanese people are linked to different types of hair loss, with some causing mild hair thinning and others leading to complete baldness.
research Inducing Hair Follicle Neogenesis by Defined Extracellular Factors
Certain factors can start hair growth in adult skin by making cells communicate and form new hair follicles.
research Squarticles as a Nanocarrier for Targeting Minoxidil to Hair Follicles and Dermal Papilla Cells
Squarticles, tiny particles made from sebum-derived lipids, can effectively deliver minoxidil, a hair growth drug, directly to hair follicles and skin cells, with less skin penetration and more tolerability.
research Highly Prevalent LIPH Founder Mutations Causing Autosomal Recessive Woolly Hair/Hypotrichosis in Japan and the Genotype/Phenotype Correlations
LIPH mutations in Japan cause varying degrees of hair loss and woolly hair.
research Canonical Wnt-10b Signaling Exerts an Ability to Maintain Mouse Dermal Papilla Cells
Wnt-10b is important for keeping mouse skin cells healthy for hair growth.
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5 / 589 resultscommunity Almost 2 weeks on peppermint oil and castor oil. Front hairline sees new baby hairs.
A user claims to see new baby hairs after using peppermint and castor oil for nearly two weeks, but others are skeptical, attributing the appearance of new hair to the way the hair is styled or pulled back.
community 57% increased chance of pattern hair loss independently associated with the consumption of sugary beverages in men (p<0.001) Pt 2
Sugary beverages increase the risk of pattern hair loss in men by 57%. Treatments discussed include Minoxidil, finasteride, and RU58841.
community PP405 Identity Research
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UmbrellaLabsResearch
in Research
292 upvotes
6 months ago PP405 is a potential hair loss treatment that inhibits mitochondrial pyruvate carriers, increasing lactate dehydrogenase activity and stimulating hair follicle stem cells. In a phase 1 trial, 31% of participants showed over 20% hair density increase with PP405 treatment.
community If RU58841 is such an effective anti androgen
RU58841 is discussed as a topical anti-androgen for hair loss, but its effectiveness and safety are not well-documented, leading to mixed opinions and experiences among users. Some combine it with finasteride, but concerns about side effects and lack of FDA approval limit its popularity.
community Why do we get bald from evolutionary perspective
Baldness is not an evolutionary disadvantage because it occurs after reproductive age. Treatments like Minoxidil and Finasteride are used for androgenetic alopecia but don't address the root cause.