May 2026 in “Jurnal Riset Kefarmasian Indonesia” This study measured caffeine content in ethanolic extracts of robusta coffee beans, finding 221.58 mg of caffeine per gram of extract, which aligns with known levels for Coffea canephora.
In a study on hair loss treatment, researchers found that a serum containing Cinchona succirubra extract and caffeine improved hair density and reduced hair loss in individuals with acute telogen effluvium after 16 weeks of use, with significant improvements observable after just 4 weeks.
January 2026 in “Dermatology Research and Practice” This study found that ex vivo, the skin permeability of caffeine increased with formulations using natural caffeine from coffee extract, particularly when combined with 2.5% Transcutol P, compared to synthetic caffeine formulations.
April 2023 in “Journal of Investigative Dermatology” In this clinical study, a serum containing Cinchona succirubra extract and Caffeine significantly improved hair growth and reduced hair loss in subjects with acute telogen effluvium.
December 2020 in “Journal of Cosmetic Science” This study determined that caffeine content in anticellulite gels was between 0.7% and 1.7%, and about 1.0% in hair-care products.